Abstract
The problem of the “discrepancies” that we raised at the Bonn and Lund Symposia in 1968, can be expressed by saying that a rigorous separation between entirely “good” and “bad” vessels does not often hold in practice. When studying CBF in brain disease one should therefore qualify the concept of “vasoparalysis”, in terms of:
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a).
the stimulus employed to test it; b) the threshold chosen to separate normal and abnormal responses, and the statistical basis for choosing such a threshold. Beside the errors of the method one should consider that the stimuli are seldom pure, since some COg change usually accompanies changes in blood pressure and specially - vice-versa; furthermore, during a test situation a true steady state is often difficult to obtain.
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References
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Fieschi, C., Agnoli, A., Bozzao, L., Battistini, N., Prencipe, M. (1969). Discrepancies Between Autoregulation and CO2 Reactivity of Cerebral Vessels. In: Brock, M., Fieschi, C., Ingvar, D.H., Lassen, N.A., Schürmann, K. (eds) Cerebral Blood Flow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85860-4_39
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