The Effect of Cortisone and Anabolic Agents on Bone
An excess of cortisone causes an osteoporosis which resembles that of Cushing’s syndrome (Sissons, 1956) and also the osteoporosis of the elderly (Valderrama and Little, 1965). Although the detailed mechanism has been only partially elucidated, anabolic agents have been used clinically to provide symtomatic relief, but practically nothing has been reported which might suggest a mechanism of action. In the present investigation rabbits were used as the experimental animal, and given cortisone alone, or an anabolic agent alone, or various combinations of the two. “Stromba” (17/β-hydroxy-17α-methylandrosteno(3.2-C)pyrazole) was the anabolic agent of choice as it is reported to give a typical anabolic action with minimal side effects.
KeywordsEstrogen Osteoporosis Testosterone Thymidine Thyroxin
Unable to display preview. Download preview PDF.
- Sissoxs, H. A.: The osteoporosis of Cushing’s syndrome. J. Bone Jt Surg. 38 B, 418 (1956).Google Scholar
- Storey, E.: The effect of intermittent cortisone administration in the rabbit. J. Bone Jt Surg. 40 B, 103 (1958).Google Scholar
- Trueta, J., and W. M. Rigal: The use of tritiated thymidine in the study of the mechanism of formation of osteoclasts. (in press).Google Scholar
- Valderrama, J. A. F. De, and K. Little: Mechanisms involved in the osteoporotic process. J. Bone Jt Surg. 47 B, 193 (1965).Google Scholar