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The Effect of Cortisone and Anabolic Agents on Bone

  • J. A. Fernandez de Valderrama
  • L. M. Munuera
Conference paper

Abstract

An excess of cortisone causes an osteoporosis which resembles that of Cushing’s syndrome (Sissons, 1956) and also the osteoporosis of the elderly (Valderrama and Little, 1965). Although the detailed mechanism has been only partially elucidated, anabolic agents have been used clinically to provide symtomatic relief, but practically nothing has been reported which might suggest a mechanism of action. In the present investigation rabbits were used as the experimental animal, and given cortisone alone, or an anabolic agent alone, or various combinations of the two. “Stromba” (17/β-hydroxy-17α-methylandrosteno(3.2-C)pyrazole) was the anabolic agent of choice as it is reported to give a typical anabolic action with minimal side effects.

Keywords

Endochondral Ossification Anabolic Agent Growth Cartilage Liferative Zone Cortisone Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Rigai, W. M., and K. Little: Some observations on nuclear structure. J. roy. micr. Soc. 80, 279 (1962).CrossRefGoogle Scholar
  2. Sissoxs, H. A.: The osteoporosis of Cushing’s syndrome. J. Bone Jt Surg. 38 B, 418 (1956).Google Scholar
  3. Storey, E.: The effect of intermittent cortisone administration in the rabbit. J. Bone Jt Surg. 40 B, 103 (1958).Google Scholar
  4. Trueta, J., and W. M. Rigal: The use of tritiated thymidine in the study of the mechanism of formation of osteoclasts. (in press).Google Scholar
  5. Valderrama, J. A. F. De, and K. Little: Mechanisms involved in the osteoporotic process. J. Bone Jt Surg. 47 B, 193 (1965).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1966

Authors and Affiliations

  • J. A. Fernandez de Valderrama
    • 1
  • L. M. Munuera
    • 1
  1. 1.Nuffield Orthopaedic CentreOxfordEngland

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