Calcium Clearance and Re-absorption in Patients with Osteoporosis, Renal Stone and Primary Hyperparathyroidism
Hypercalciuria is known to occur in patients with hyperparathyroidism and in about 30% of patients with renal stone disease. It is not yet known for certain whether there is any difference in calcium reabsorption by the tubules in these conditions. Kleeman et al. (1958) reported that there was decreased clearance of calcium in normal subjects following the administration of parathyroid hormone during calcium infusion. Loken and Gordan (1959), and Gordan et al. (1962) reported that calcium clearance was in fact increased in patients with primary hyperparathyroidism and decreased in patients with hypoparathyroidism. Bernstein et al. (1963) showed a decreased calcium clearance in patients with hypoparathyroidism given parathyroid hormone during calcium infusion. They also pointed out the importance of associating the calcium clearance with the level of the plasma diffusible calcium. Since some doubt remained, it was decided to investigate this further.
KeywordsOsteoporosis Creatinine Hyperparathyroidism Gluconate Hypoparathyroidism
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