Abstract
Hypercalciuria is known to occur in patients with hyperparathyroidism and in about 30% of patients with renal stone disease. It is not yet known for certain whether there is any difference in calcium reabsorption by the tubules in these conditions. Kleeman et al. (1958) reported that there was decreased clearance of calcium in normal subjects following the administration of parathyroid hormone during calcium infusion. Loken and Gordan (1959), and Gordan et al. (1962) reported that calcium clearance was in fact increased in patients with primary hyperparathyroidism and decreased in patients with hypoparathyroidism. Bernstein et al. (1963) showed a decreased calcium clearance in patients with hypoparathyroidism given parathyroid hormone during calcium infusion. They also pointed out the importance of associating the calcium clearance with the level of the plasma diffusible calcium. Since some doubt remained, it was decided to investigate this further.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bernstein, D., C. R. Kleeman, and M. H. Maxwell: The effect of calcium infusions, parathyroid hormone and vitamin D on renal clearance of calcium. Proc. Soc. exp. Biol. 112, 353 (1963).
Gordan, G. S., H. F. Loken, A. Blum, and J. S. Teal: Renal handling of calcium in parathyroid disorders. Metabolism 11, 94 (1962).
Kleeman, C. R., R. E. Rockney, and M. H. Maxwell: The effect of parathyroid extract (PTE) on the renal clearance of diffusible calcium. J. clin. Invest. (Abstract) 37, 907 (1958).
Loken, H. F., and G. S. Gordan: Renal mechanisms in the production of hypercalcaemia in hyperparathyroidism and breast cancer. J. clin. Invest. (Abstract) 38, 1021 (1959).
Macfadyen, I. J., B. E. C. Nordin, D. A. Smith, D. J. Wayne, and S. L. Rae: Effect of variation in dietary calcium on plasma concentration and urinary excretion of calcium. Brit. med. J. 1, 161 (1965).
Mcpherson, G. D.: Regulation of plasma calcium in man. Thesis. University of British Columbia 1959.
Toribara, T. Y., A. R. Terepka, and P. A. Dewey: The ultrafilterable calcium of human serum. I. Ultrafiltration methods and normal values. J. clin. Invest. 40, 738 (1957).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1966 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Smith, D.A., Mackenzie, J.C. (1966). Calcium Clearance and Re-absorption in Patients with Osteoporosis, Renal Stone and Primary Hyperparathyroidism. In: Fleisch, H., Blackwood, H.J.J., Owen, M. (eds) Calcified Tissues 1965. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85841-3_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-85841-3_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-85843-7
Online ISBN: 978-3-642-85841-3
eBook Packages: Springer Book Archive