Calcium Clearance and Re-absorption in Patients with Osteoporosis, Renal Stone and Primary Hyperparathyroidism

  • D. A. Smith
  • J. C. Mackenzie
Conference paper

Abstract

Hypercalciuria is known to occur in patients with hyperparathyroidism and in about 30% of patients with renal stone disease. It is not yet known for certain whether there is any difference in calcium reabsorption by the tubules in these conditions. Kleeman et al. (1958) reported that there was decreased clearance of calcium in normal subjects following the administration of parathyroid hormone during calcium infusion. Loken and Gordan (1959), and Gordan et al. (1962) reported that calcium clearance was in fact increased in patients with primary hyperparathyroidism and decreased in patients with hypoparathyroidism. Bernstein et al. (1963) showed a decreased calcium clearance in patients with hypoparathyroidism given parathyroid hormone during calcium infusion. They also pointed out the importance of associating the calcium clearance with the level of the plasma diffusible calcium. Since some doubt remained, it was decided to investigate this further.

Keywords

Osteoporosis Creatinine Hyperparathyroidism Gluconate Hypoparathyroidism 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bernstein, D., C. R. Kleeman, and M. H. Maxwell: The effect of calcium infusions, parathyroid hormone and vitamin D on renal clearance of calcium. Proc. Soc. exp. Biol. 112, 353 (1963).Google Scholar
  2. Gordan, G. S., H. F. Loken, A. Blum, and J. S. Teal: Renal handling of calcium in parathyroid disorders. Metabolism 11, 94 (1962).PubMedGoogle Scholar
  3. Kleeman, C. R., R. E. Rockney, and M. H. Maxwell: The effect of parathyroid extract (PTE) on the renal clearance of diffusible calcium. J. clin. Invest. (Abstract) 37, 907 (1958).Google Scholar
  4. Loken, H. F., and G. S. Gordan: Renal mechanisms in the production of hypercalcaemia in hyperparathyroidism and breast cancer. J. clin. Invest. (Abstract) 38, 1021 (1959).Google Scholar
  5. Macfadyen, I. J., B. E. C. Nordin, D. A. Smith, D. J. Wayne, and S. L. Rae: Effect of variation in dietary calcium on plasma concentration and urinary excretion of calcium. Brit. med. J. 1, 161 (1965).PubMedCrossRefGoogle Scholar
  6. Mcpherson, G. D.: Regulation of plasma calcium in man. Thesis. University of British Columbia 1959.Google Scholar
  7. Toribara, T. Y., A. R. Terepka, and P. A. Dewey: The ultrafilterable calcium of human serum. I. Ultrafiltration methods and normal values. J. clin. Invest. 40, 738 (1957).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1966

Authors and Affiliations

  • D. A. Smith
    • 1
  • J. C. Mackenzie
    • 1
  1. 1.Gardiner Institute, Western InfirmaryUniversity Department of MedicineGlasgowScotland

Personalised recommendations