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Remodelling of the Bone Matrix

  • Conference paper
Calcified Tissues 1965

Abstract

Bone, the supporting frame of vertebrate animals is made of a two-phase material, the collagen matrix and the hydroxyapatite crystals. The organization of the collagen fibers and of the crystals is such that these two materials with different elastic moduli and strength carry out their mutual function organized as trabeculae and account for the mechanical properties of bone (Currey, 1964). Strongly regulated mechanisms involving synthesis and degradation of the matrix and of the crystal lattice, are probably responsible for such a high degree of organization.

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References

  • Bélanger, L. F., J. Robichon, B. B. Migicovsky, D. H. COPP, and J. Vincent: Resorption without osteoclasts (osteolysis). In Mechanisms of Hard Tissue Destruction. SOGNNAES, R. J. (ed.) Washington: Amer. Ass. Advanc. Sci. 1963, p. 531.

    Google Scholar 

  • Currey, J. D.: Three analogies to explain the mechanical properties of bone. Biorheol. 2, 1 (1964).

    Google Scholar 

  • Eastoe, J. E.: The organic matrix of bone. In The Biochemistry and Physiology of Bone. Bourne, G. H. (ed.). New York: Academic Press 1956, p. 81.

    Google Scholar 

  • Flanagan, B., and G. Nichols: Direct measurements of human bone metabolism in normal and hyperparathyroid subjects. Clin. Res. 12, 266 (1964).

    Google Scholar 

  • Gaillard, P. J.: Parathyroid gland and bone in vitro. Develop. Biol. 1, 152 (1959).

    Article  Google Scholar 

  • Glimcher, M. J.: Molecular biology of mineralized tissues with particular reference to bone. Rev. mod. Phys. 31, 359 (1959).

    Article  CAS  Google Scholar 

  • Glimcher, M. J. The organization of collagen in bone. In Symposium international sur la biochimie et la physiologie du tissu conjonctif. Delaunay, A. (ed.). (In press.)

    Google Scholar 

  • Glimcher, M. J., A. J. Hodge, and F. O. Schmitt: Macromolecular aggregation states in relation to mine ralization: the collagen hydroxyapatite system as studied in vitro. Proc. nat. Acad. Sci. 43, 860 (1957).

    Article  CAS  Google Scholar 

  • Glimcher, M. J., and S. M. krane: Studies of the interaction of collagen and phosphate. I. The nature of inorganic orthophosphate binding. In Radioisotopes and Bone. LACROIX, P., and A. M. Bun (eds.). Oxford: Blackwell Scientific Publications 196x2, p. 393.

    Google Scholar 

  • Goldhaber, P.: The effect of hyperoxia on Bone Resorption in Tissue Culture. A. M. A. Arch. Path. 66, 635 (1958).

    PubMed  CAS  Google Scholar 

  • Green, N. M., and D. A. Lowther: Formation of collagen hydroxyproline in vitro. Biochem. J. 71, 55 (1959).

    PubMed  CAS  Google Scholar 

  • Gross, J.: Studies on the formation of collagen. I. Properties and fractionation of neutral salt extracts of normal guinea pigs connective tissue. J. exp. Med. 107, 247 (1958 a).

    Google Scholar 

  • Gross, J.: Studies on the formation of collagen. II. The influence of growth rate on neutral salt extracts of guinea pigs dermis. J. exp. Med. 107, 265 (1958 b).

    Google Scholar 

  • Gross, J.: Studies on the formation of collagen. III. Time-dependent solubility changes of collagen in vitro. J. exp. Med. 108, 215 (1958 c).

    Google Scholar 

  • Gross, J.: On the significance of the soluble collagens. In Connective Tissue, Thrombosis and Atherosclerosis. PAGE, I. H. (ed.). New York: Academic Press 1959, p. 77.

    Google Scholar 

  • Gross, J.: An intermolecular defect of collagen in experimental lathyrism. Biochim. biophys. Acta 71, 250 (1963a).

    CAS  Google Scholar 

  • Gross, J.: Comparative biochemistry of collagen. In Comparative Biochemistry, A Comprehensive Treatise. FLORKIN, M., and H. S. MASON (eds.). New York: Academic Press 1963 b, p. 307.

    Google Scholar 

  • Gross, J., and CH. M. Lapiere: Collagenolytic activity in amphibian tissues: A tissue culture assay. Proc. nat. Acad. Sci. 48, 1014 (1962).

    Article  CAS  Google Scholar 

  • Hancox, N. M., and B. Boothroyd: Structure-function relationships in the osteoclast. In Mechanisms of Hard Tissue Destruction. Sognnaes, R. J. (ed.). Washington: Amer. Ass. Advanc. Sci. 1963, p. 497.

    Google Scholar 

  • Harkness, R. D.: Biological functions of collagen. Biol. Rev. 36, 399 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Harkness, R. D.: A. M. Marko, H. M. Muir, and A. Neuberger: The metabolism of collagen and other proteins of the skin of rabbits. Biochem. J. 56, 558 (1954).

    PubMed  CAS  Google Scholar 

  • Hay, E. D., and J. P. Revel: Autoradiographic studies of the origin of the basement lamella in Amblyostoma. Develop. Biol. 7, 152 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Herman, H., et L. Richelle: Le calcium échangeable de la substance minérale de los étudiée â laide du Ca-45. VII. Activité comparée de fractions dos total de densité différente. Bull. Soc. Chim. Biol. 43, 273 (1961).

    PubMed  CAS  Google Scholar 

  • Jackson, D. S.: Connective tissue growth stimulated by carrageenin. I. The formation and removal of collagen. Biochem. J. 65, 277 (1957).

    PubMed  CAS  Google Scholar 

  • Herman, H., and J. P. Bentley: On the nature of the extractable collagens. J. biophys. biochem. Cytol. 7, 37 (1960).

    Article  Google Scholar 

  • Jackson, S. F.: The structure of developing bone in the embryonic fowl. Proc. roy. Soc. B 146, 270 (1957).

    Google Scholar 

  • Jowsey, J., R. E. Rowland, J. H. Marshall, and F. C. Mclean: The effect of parathyroidectomy on haversian remodeling of bone. Endocrinology 63, 903 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Krane, S. M., and M. J. Glimcher: Studies of the interaction of collagen and phosphate. II. Nucleotidase activity and binding of nucleotide phosphorus. In Radioisotopes and Bone. Lacroix, P., and A. M. Budy (eds.). Oxford: Blackwell Scientific Publications 1962, p. 419.

    Google Scholar 

  • Lapiere, CH. M., A. Bruschi, M. L. Tanzer, and J. Gross: Metabolic behaviour of the collagen in steady state and remodelling tissues. In Calcified Tissues. Richelle, L. J., et M. J. Dallemagne (eds.). Liège: Collection des colloques de lUniversité de Liège 1965, P. 275.

    Google Scholar 

  • Lapiere, CH. M., A. Bruschi, M. L. Tanzer, and J. Gross: and J. Gross: Animal collagenase and collagen metabolism. In Mechanisms of Hard Tissue Destruction. Sognnaes, R. J. (ed.). Washington: Amer. Ass. Advanc. Sci. 1963, p. 663.

    Google Scholar 

  • Lapiere, CH. M., A. Bruschi, M. L. Tanzer, and J. Gross: C. Onkelinx, and L. J. Richelle: Collagen metabolism in skin and bone. In Symposium international sur la biochimie et la physiologie du tissu conjonctif. DELAUNAY, A. (ed.). (In press.)

    Google Scholar 

  • Levene, CH. I., and J. GROSS: Alteration in state of molecular aggregation of collagen in duced in chick embryos by fi-aminopropionitrile (Lathyrus factor). J. exp. Med. 110, 771 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J. H., R. E. Rowland, and J. Jowsey: Microscopic metabolism of calcium in bone. II. Quantitative autoradiography. Radiat. Res. 10, 213 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Martin, R. G., J. Gross, K. A. Piez, and M. S. Lewis: On the intramolecular cross linking of collagen in lathyritics rats. Biochim. biophys. Acta 53, 599 (1961).

    CAS  Google Scholar 

  • Mclean, F., and R. E. Rowland: Internal remodeling of compact bone. In Mechanisms of Hard Tissue Destruction. Sognnaes, R. J. (ed.). Washington: Amer. Ass. Advanc. Sci. 1963, p. 371.

    Google Scholar 

  • Mclean, F., and R. E. Rowland, and M. R. Urist: An introduction to the physiology of skeletal tissue. In Bone. Chicago: The University of Chicago Press 1961.

    Google Scholar 

  • Nagai, Y., CH. M. Lapiere, and J. Gross: Isolation and partial characterization of an animal collagenolytic enzyme. Fed. Proc. 22, 648 (1963).

    Google Scholar 

  • Nagai, Y., CH. M. Lapiere, and J. Gross: Purification and characterization of amphibian collagenolytic enzyme. Abstract 6th. International Congress of Biochemistry, N. Y. 1964.

    Google Scholar 

  • Neuberger, A., and H. G. B. Slack: The metabolism of collagen from liver, bone, skin and tendon in the normal rat. Biochem. J. 53, 47 (1953).

    PubMed  CAS  Google Scholar 

  • Orekhovitch, V. N., V. O. Chpikiter, V. I. Mazourov, et O. V. Kounina: Procollagènes. Classification, métabolisme, action des protéinases. Bull. Soc. Chim. biol. 42, 505 (1960).

    PubMed  CAS  Google Scholar 

  • Piez, K. A., M. S. Lewis, G. R. Martin, and J. Gross: Subunits of the collagen molecule. Biochim. biophys. Acta 53, 596 (1961).

    CAS  Google Scholar 

  • Richelle, L. J.: One possible solution to the problem of the biochemistry of bone mineral. Clin. Orthop. 33, 211 (1964).

    PubMed  CAS  Google Scholar 

  • Richelle, L. J, and F. Bronner: The calcium exchange reaction of bone in vitro. Effect of parathyroid extract. Biochem. Pharmacol. 12, 647 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Richelle, L. J, C. Onkelinx, and J. P. Aubert: Mineral metabolism in the rat. This Book 1965, p. 123.

    Google Scholar 

  • Robinson, R. A.: Chemicalanalysis and electronmicroscopy of bone. In Bone as a Tissue. Rodahl, K., J. T. Nicholson, and E. M. Brown (eds.). New York: Mac Graw Hill 1960, p. 186.

    Google Scholar 

  • Scort, B. L., and M. J. Glimcher: Intracellular pathway and extrusion of collagen in the osteoblasts of developing bone. J. appl. Phys. 34, 2524 (1963).

    Google Scholar 

  • Smith, J. W.: Age changes in the organic fraction of bone. J. Bone Jt Surg. 45 B, 761 (1963).

    Google Scholar 

  • Stern, B. D., G. L. Mechanic, M. J. Glimcher, and P. Goldhaber: The resorption of bone collagen in tissue culture. Biochem. biophys. Res. Commun. 13, 137 (1963).

    Google Scholar 

  • Tanzer, M. L., and J. GROSS: Collagen metabolism in the normal and lathyritic chick. J. exp. Med. 119, 275 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Tanzer, M. L., and J. Gross, and R. D. Hunt: Experimental lathyrism. An autoradiographic study. J. Cell Biol. 22, 623 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Usuxu, G., and J. Gross: Morphologic studies of connective tissue resorption in the tailfin of metamorphosing bullfrog tadpole. Develop. Biol. 11, 352 (1965).

    Article  Google Scholar 

  • Vaes, G.: Acid hydrolases and lysosomes in bone cells. Abstract 1st Meeting Federation European Biochemical Societies. London 1964, p. 83.

    Google Scholar 

  • Walker, D. G., CH. M. Lapiere, and J. Gross: A collagenolytic factor in rat bone pro moted by parathyroid extract. Biochem. biophys. Res. Commun. 15, 397 (1964).

    CAS  Google Scholar 

  • Weber, R.: On the biological function of cathepsins in tail tissue of Xenopus larvae. Ex perientia 13, 153 (1957).

    CAS  Google Scholar 

  • Woessner, J. F., and T. H. Brewer: Formation and breakdown of collagen and elastin in the human uterus during pregnancy and postpartum involution. Biochem. J. 89, 75 (1963).

    PubMed  CAS  Google Scholar 

  • Woods, J. F., and G. Nichols: Collagenolytic activity in mammalian bone. Science 142. 386 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Woods, J. F., and G. Nichols: The intracellular location of bone “collagenase”. Fed. Proc. 23, 550 (1964).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institut de Médecine, Département de Clinique et de Pathologie Médicales, Liège, Belgique

    Ch. M. Lapiére

  2. Laboratoire de Dermatologie Expérimentale, Université de Liège, Hôpital de Bavière, Liège, Belgique

    Ch. M. Lapiére

Authors
  1. Ch. M. Lapiére
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Editor information

Editors and Affiliations

  1. Laboratorium für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Schweiz

    H. Fleisch

  2. Royal Dental Hospital, School of Dental Surgery, London, England

    H. J. J. Blackwood

  3. M.R.C. Bone-seeking Isotopes Research Unit, Churchill Hospital, Oxford, England

    M. Owen

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© 1966 Springer-Verlag Berlin · Heidelberg

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Lapiére, C.M. (1966). Remodelling of the Bone Matrix. In: Fleisch, H., Blackwood, H.J.J., Owen, M. (eds) Calcified Tissues 1965. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85841-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-85841-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85843-7

  • Online ISBN: 978-3-642-85841-3

  • eBook Packages: Springer Book Archive

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