Advertisement

Die Bedeutung struktureller Gefäßveränderungen bei der essentiellen Hypertonie

  • R. Kolloch
Conference paper
  • 10 Downloads

Zusammenfassung

Das Ziel einer antihypertensiven Therapie ist nicht allein die Blutdrucksenkung, sondern protektive und ggf. reparative Effekte im Bereich des kardiovaskulären Systems sollten durch die Behandlung erreicht werden. In diesem Zusammenhang sind strukturelle Gefäßwandveränderungen wie die Mediahypertrophie von besonderer Bedeutung [8, 9, 11, 14].

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Asmar RG, Journo HJ, Lacolley Pi, Santoni JP, Billaud E, Levy BI, Safar ME (1988) Treatment for one year with perindopril: effect on cardiac mass and arterial compliance in essential hypertension. J Hypertension 6 (Suppl 3): 33–39Google Scholar
  2. 2.
    Asmar RG, Pannier B, Santoni JP, Laurent S, London GM, Levy BI, Safar ME (1988) Reversion of cardiac hypertrophy and reduced arterial compliance after converting enzyme inhibition in essential hypertension. Circulation 78: 941–950PubMedCrossRefGoogle Scholar
  3. 3.
    Bevan RD (1984) Trophic effects of peripheral adrenergic nerves on vascular structure. Hypertension 6 (Suppl III): III - 19CrossRefGoogle Scholar
  4. 4.
    Blaes N, Boissel JP (1983) Growth-stimulating effect of catecholamines on rat aortic smooth muscle cells in culture. J Cell Physiol 116: 167–172PubMedCrossRefGoogle Scholar
  5. 5.
    Bolton TB (1979) Mechanism of action of transmitters and other substances on smooth muscle. Physiol Rev 59: 606–718PubMedGoogle Scholar
  6. 6.
    Brush JE, Jr, Cannon RO, Schenke WH, Bonow RO, Leon MB, Maron BJ, Epstein SE (1988) Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy. N Engl J Med 319 /20: 1302–1307PubMedCrossRefGoogle Scholar
  7. 7.
    Christensen KL, Lennard TJ, Mulvany MJ (1989) Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-term treatment related to vascular structure. J Hypertension 7: 83–90CrossRefGoogle Scholar
  8. 8.
    Cruickshank JN, Thurp JM, Zacharias JF (1987) How far to lower blood pressure? Lancet II: 695Google Scholar
  9. 9.
    Floras JS (1987) Antihypertensive treatment, myocardial infarction, and nocturnal myocardial ischaemia. Lancet II: 994–996Google Scholar
  10. 10.
    Folkow B (1978) Cardiovascular structural adaptation; its role in the initiation and maintenance of primary hypertension. Clin Sci Molec Med 55:3 S-22 SGoogle Scholar
  11. 11.
    Frohlich ED, Tarazi RC (1979) Is arterial pressure the sole factor responsible for hypertensive cardiac hypertrophy? Am J Cardiol 44: 956CrossRefGoogle Scholar
  12. 12.
    Heagerty AM, Bund SJ, Aalkjaer C (1988) Effects of drug treatment on human resistance arteriole morphology in essential hypertension: direct evidence for structural remodelling of resistance vessels. Lancet II: 1209–1212Google Scholar
  13. 13.
    Kawahara Y, Sunako M, Tsuda T, Fukuzaki H, Fukumoto Y, Takai Y (1988) Angiotensin II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 150: 52–59PubMedCrossRefGoogle Scholar
  14. 14.
    Kolloch R (1989) Hypertonie and Herzkrankheiten. MMW 131.860–863Google Scholar
  15. 15.
    Levy BI, Michel JB, Salzmann JL, Azizi M, Poitevin P, Camilleri JP, Safar ME (1988) Arterial effects of angiotensin converting enzyme inhibition in renovascular and spontaneously hypertensive rats. J Hypertension 6 (Suppl 3): S23 — S25Google Scholar
  16. 16.
    Lundin SA, Margareta IL, Hallbäck M (1984) Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats. J Hypertension 2: 11CrossRefGoogle Scholar
  17. 17.
    Marx JL (1986) The yin and yang of cell growth control. Science 232: 1093PubMedCrossRefGoogle Scholar
  18. 18.
    Michel JP, Levy BI (1990) Vascular effects of ACE inhibition by Perindopril. Drugs 39 (Suppl I): 39–42PubMedCrossRefGoogle Scholar
  19. 19.
    Mitsuhashi M, Payan DG (1987) The mitogenic effects of vasoactive neuropeptides on cultured smooth muscle cell lines. Life Sci 40: 853PubMedCrossRefGoogle Scholar
  20. 20.
    Opherk D, Mall G, Zebe H, et al. (1984) Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. Circulation 69: 1–7PubMedCrossRefGoogle Scholar
  21. 21.
    Owens GK (1987) Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats. Hypertension 9: 178PubMedCrossRefGoogle Scholar
  22. 22.
    Owens GK, Schwartz SM (1983) Vascular smooth muscle cell hypertrophy and hyperploidy in the Goldblatt hypertensive rat. Circulat Res 53: 491–501PubMedCrossRefGoogle Scholar
  23. 23.
    Pfeffer FM, Pfeffer MA, Mirsky I, Braunwald E (1982) Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acad Sci USA 79: 3310PubMedCrossRefGoogle Scholar
  24. 24.
    Re RN (1984) Cellular biology of the renin-angiotensin systems. Arch Intern Med 144: 2037–2041PubMedCrossRefGoogle Scholar
  25. 25.
    Re RN, Rovigatti U (1988) New approaches to the study of the cellular biology of the cardiovascular system. Circulation 77 (Suppl I): I - 14Google Scholar
  26. 26.
    Rovigatti UR, Re RN (1987) The role of proto-oncogenes in the development of sequelae of hypertension. Hypertension 10: 358Google Scholar
  27. 27.
    Sano T, Tarazi R (1987) Differential structural responses of small resistance vessels to antihypertensive therapy. Circulation 75: 618–626PubMedCrossRefGoogle Scholar
  28. 28.
    Stewart I (1979) Relation of reduction in pressure to first myocardial infarction in patients receiving treatment for severe hypertension. Lancet I: 861–865Google Scholar
  29. 29.
    Strandgaard S (1976) Autoregulation of cerebral blood flow in hypertensive patients: the modifying influence of prolonged antihypertensive treatment on the tolerance to acute drug-induced hypotension. Circulation 53: 720–727PubMedCrossRefGoogle Scholar
  30. 30.
    Strauer BE (1985) Progression and Regression der Herzhypertrophie beim arteriellen Bluthochdruck: Pathophysiologie and Klinik. Z Kardiol 74 (Suppl 7): 171–178PubMedGoogle Scholar
  31. 31.
    Tarazi RC, Fouad FM (1984) Reversal of cardiac hypertrophy in humans. Hypertension 6 (Suppl III): III - 140CrossRefGoogle Scholar
  32. 32.
    Warshaw DM, Root DT, Halpern W (1980) Effects of antihypertensive drug therapy on the morphology and mechanics of resistance arteries from spontaneously hypertensive rats. Blood Vessels 1: 257Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. Kolloch

There are no affiliations available

Personalised recommendations