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Lokale Hemmung des Konversionsenzyms in Gefäßen durch Konversionsenzymhemmer: funktionelle und morphologische Aspekte

  • Th. Unger
  • P. Gohlke
Conference paper
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Zusammenfassung

Unser Wissen über blutdruckregulierende Hormonsysteme hat sich in den letzten Jahren sprunghaft erweitert. Dies gilt insbesondere für das Renin-Angiotensin-System (RAS).

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Literatur

  1. 1.
    Assad MM, Antanaccio MJ (1982) Vascular wall renin in spontaneously hypertensive rats. Hypertension 4: 487–493CrossRefGoogle Scholar
  2. 2.
    Campbell DJ, Habener JF (1986) Angiotensinogen gene as expressed and differentially regulated in multiple tissues of the rat. J Clin Invest 78: 31–39PubMedCrossRefGoogle Scholar
  3. 3.
    Chevillard C, Brown NL, Mathieu M-N, Laliberte F, Worcel M (1988) Differential effects of oral trandolapril and enalapril on rat tissue angiotensin-converting enzyme. Eur J Pharmacol 147: 23–28PubMedCrossRefGoogle Scholar
  4. 4.
    Christensen LK, Jespersen LT, Mulvany MJ (1988) Therapeutic regression of resistance vessel structure in spontaneously hypertensive rats does not necessarily inhibit redevelopment of blood pressure on stopping treatment. (Proceedings of 12th Scientific Meeting of the International Society of Hypertension, Kyoto, Abstract 0189 )Google Scholar
  5. 5.
    Cohen ML, Kurz KD (1982) Angiotensin converting enzyme inhibition in tissues from spontaneously hypertensive rats after treatment with captopril or MK-421. J Pharmacol Exp Ther 220: 63–69PubMedGoogle Scholar
  6. 6.
    Cohen ML, Kurz KD, Schenk KW (1983) Tissue angiotensin converting enzyme inhibition as an index of the disposition of enalapril (MK-421) and metabolite MK-422. J Pharmacol Exper Ther 226: 192–196Google Scholar
  7. 7.
    Darby I, Aldred P, Crawford RJ, Fernley RT, Niall HD, Penschow JD, Ryan GB, Coghlan JP (1985) Gene expression in vessels of the ovine renal cortex. J Hypertension 3: 9–12CrossRefGoogle Scholar
  8. 8.
    Dzau VJ (1987) Vascular angiotensin pathways: a new therapeutic target. J Cardiovasc Pharmacol 10 (Suppl 7): S 9 — S16CrossRefGoogle Scholar
  9. 9.
    Dzau VJ, Safar ME (1988) Large conduit arteries in hypertension: role of the vascular renin-angiotensin system. Circulation 77: 947–954PubMedCrossRefGoogle Scholar
  10. 10.
    Ganten D, Hayduk K, Brecht HM, Boucher R, Genest J (1970) Evidence of renin release or production in splanchnic territory. Nature 226: 551PubMedCrossRefGoogle Scholar
  11. 11.
    Henrichs KJ, Unger Th, Berecek KH, Ganten D (1980) Is arterial media hypertrophy in spontaneously hypertensive rats a consequence of or a cause for hypertension. Clin Sci 59:331 s-333 sGoogle Scholar
  12. 12.
    Jackson B, Cubela R, Johnston C (1986) Angiotensin converting enzyme (ACE), characterization by 125I-MK351A binding studies of plasma and tissue ACE during variation of salt status in the rat. J Hypertension 4: 759–765CrossRefGoogle Scholar
  13. 13.
    Kuriyama S, Nakamura A, Hopp L, Fine BP, Kino M, Cragoe E Jr, Aviv A (1988) Angiotensin II effect on 22Na+-transport in vascular smooth muscle cells. J Cardiovasc Pharmacol 11: 139–146PubMedGoogle Scholar
  14. 14.
    Longman SD, Howlett DR (1986) Angiotensin-converting enzyme responses following enalapril in the sodium deficient rat. Eur J Pharmacol 123: 379–386PubMedCrossRefGoogle Scholar
  15. 15.
    Malik KU, Nasjletti A (1976) Facilitation of adrenergic transmission by locally generated angiotensin II in rat mesenteric arteries. Circ Res 38: 26–30PubMedCrossRefGoogle Scholar
  16. 16.
    Miyazaki M, Okunishi H, Mishimura K, Toda N (1984) Vascular angiotensin-converting enzyme activity in man and other species. Clin Sci 66: 39–45PubMedGoogle Scholar
  17. 17.
    Nakamura Y, Nakamura K, Matsukura T (1988) Vascular angiotensin converting enzyme activity in spontaneously hypertensive rats and its inhibition with cilazapril. J Hypertension 6: 105–110CrossRefGoogle Scholar
  18. 18.
    Nakata K, Nishimura K, Takada T, Ikuse T, Yamauchi H, Iso T (1987) Effects of an angiotensin-converting enzyme ACE inhibitor, SA446, on tissue ACE activity in normotensive, spontaneously hypertensive, and renal hypertensive rats. J Cardiovasc Pharmacol 9: 305–310PubMedCrossRefGoogle Scholar
  19. 19.
    Nambu K, Matsumoto K, Takeyama K, Hosoki, Miyazaki H, Hashimoto M (1986) Tissue levels, tissue angiotensin converting enzyme inhibition and antihypertensive effect of the novel antihypertensive agent alacepril in renal hypertensive rats. Drug Res 36 (1): 47–51Google Scholar
  20. 20.
    Okunishi H, Miyazaki M, Okamura T, Toda N (1987) Different distribution of two types of angiotensin II-generating enzymes in the aortic wall. Biochem Biophys Res Comm 149: 1186–1192PubMedCrossRefGoogle Scholar
  21. 21.
    Oliver JA, Sciacca RR (1984) Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat. J Clin Invest 74: 1247–1251PubMedCrossRefGoogle Scholar
  22. 22.
    Oshima T, Matsushita Y, Miyamoto M, Koike H (1983) Effects of long-term blockade of angiotensin converting enzyme with captopril on blood pressure and aortic prolyl hydroxylase activity in spontaneously hypertensive rats. Eur J Pharmacol 91: 283–286PubMedCrossRefGoogle Scholar
  23. 23.
    Rosenthal J, Boucher R, Rojo Ortega JM, Genest J (1969) Renin activity in aortic tissue of rats. Can J Physiol Pharmacol 47: 53PubMedCrossRefGoogle Scholar
  24. 24.
    Saye JA, Singer HA, Peach MJ (1984) Role of endothelium in conversion of angiotensin I to angiotensin II in rabbit aorta. Hypertension 6: 216–221PubMedGoogle Scholar
  25. 25.
    Skidgel RA, Defendini R, Erdös EG (1988) Angiotensin I converting enzyme and its role in neuropeptide metabolism. In: Turner Ai (ed) Neuropeptides and their Peptidases. Horwood, Chichester, pp 165–188Google Scholar
  26. 26.
    Swales JD, Heagerty AM (1987) Vascular renin-angiotensin system: the unanswered questions. J Hypertension 5: S 1—S 5Google Scholar
  27. 27.
    Thurston H, Swales JD (1977) Blood pressure response of nephrectomized hypertensive rats to converting enzyme inhibition: evidence for persistent vascular renin activity. Clin Sci Mol Med 52: 299–304PubMedGoogle Scholar
  28. 28.
    Thurston H, Swales JD, Bing RF, Hurst BC, Marks ES (1979) Vascular renin-like activity and blood pressure maintenance in the rat: Studies of the effect of changes in sodium balance, hypertension and nephrectomy. Hypertension 1: 643–649Google Scholar
  29. 29.
    Toda N (1984) Endothelium-dependent relation induced by angiotensin II and histamine in isolated arteries of dog. Br J Pharmacol 81: 301–307PubMedCrossRefGoogle Scholar
  30. 30.
    Unger Th, Hübner D, Schüll B, Lang RE, Rascher W, Rettig R, Ganten D (1982) Effect of chronic oral captopril treatment on tissue renin concentration and converting enzyme activity in stroke-prone spontaneously hypertensive rats. In: Rascher W, Clough D, Ganten D (eds) Hypertensive Mechanisms. Schattauer, Stuttgart New York, pp 768 —773Google Scholar
  31. 31.
    Unger Th, Ganten D, Lang RE, Schölkens BA (1984 a) Is tissue converting enzyme inhibition a determinant of the antihypertensive efficacy of converting enzyme inhibitors? Studies with the two different compounds, Hoe498 and MK421, in spontaneously hypertensive rats. J Cardiovasc Pharmacol 6: 872–880Google Scholar
  32. 32.
    Unger Th, Fleck Th, Ganten D, Lang RE, Rettig R (1984b) 2-(N)-(S)-1-Ethoxycarbonyl-3-phenylpropyl-L-alamyl)-(1S,3S,5S)-2-azabicyclo (3.3.0)octane-3-carboxylic acid (Hoe498): antihypertensive action and persistent inhibition of tissue converting enzyme activity in spontaneously hypertensive rats. Drug Res 34 (II): 1426–1430Google Scholar
  33. 33.
    Unger Th, Ganten D, Lang RE, Schölkens BA (1985) Persistent tissue converting enzyme inhibition following chronic treatment with Hoe498 and MK421 in spontaneously hypertensive rats. J Cardiovasc Pharmacol 7: 36–41PubMedCrossRefGoogle Scholar
  34. 34.
    Unger Th, Moursi M, Ganten D, Hermann K, Lang RE (1986 a) Antihypertensive action of the converting enzyme inhibitor perindopril (S9490–3) in spontaneously hypertensive rats: comparison with enalapril (MK421) and ramipril (Hoe498). J Cardiovasc Pharmacol 8: 276–285Google Scholar
  35. 35.
    Unger Th, Ganten D, Lang RE (1986 b) Tissue converting enzyme and cardiovascular actions of converting enzyme inhibitors. J Cardiovasc Pharmacol 8 (Suppl 10): S 75—S 81Google Scholar
  36. 36.
    Unger Th, Gohlke P, Ganten D, Lang RE (1989) Converting enzyme inhibitors and their effects on the renin-angiotensin system of the blood vessel wall. J Cardiovasc Pharmacol 13 (Suppl 3): S 8—S 16Google Scholar
  37. 37.
    Velletri P, Bean BL (1982) The effect of captopril on rat aortic angiotensin-converting enzyme. J Cardiovasc Pharmacol 4: 315–325PubMedCrossRefGoogle Scholar
  38. 38.
    Wilson SK, Lynch DR, Snyder SH (1987) Angiotensin-converting enzyme labelled with [3H]Captopril. Tissue localization and changes in different models of hypertension in the rat. J Clin Invest 80: 841–851Google Scholar
  39. 39.
    Zimmermann BG (1981) Adrenergic facilitation by angiotensin: Does it serve a physiological function? Clin Sci 60: 343–348Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Th. Unger
  • P. Gohlke

There are no affiliations available

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