Abstract
It is of both fundamental and practical importance to determine whether the Lucké renal carcinoma of the frog is induced by a herpes-like virus. Definitive evidence that a member of the herpesvirus group induces a tumor in any species would spur efforts to determine whether human neoplasms such as Burkitt’s lymphoma and cervical cancer are induced by similar viral agents. An evaluation of the evidence required to indict a virus as a causative agent of neoplastic disease is appropriate at this time. For this purpose I will review the recent results of studies on adenovirus transformed cells and adenovirus induced tumors of hamsters, rats, and mice in which the concepts and methodology of molecular biology have been successfully employed to detect viral gene activity in adenovirus tumor and transformed cells, to investigate the mechanism of viral oncogenesis, and to analyze human tumors for adenovirus genetic information.
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References
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Green, M. (1969). Nucleic Acid Homology as Applied to Investigations on the Relationship of Viruses to Neoplastic Diseases. In: Mizell, M. (eds) Biology of Amphibian Tumors. Recent Results in Cancer Research, vol 1969. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85791-1_39
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DOI: https://doi.org/10.1007/978-3-642-85791-1_39
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