Abstract
Since 1964, when Epstein et al. (1) described the presence of herpesvirus in cultured cells of a biopsy of Burkitt lymphoma, many investigators from various parts of the world have confirmed and extended this observation. To date, cell lines have been successfully grown in culture from at least 125 individuals (2). Of those derived from malignant states, including leukemia and lymphoma, 44 of 105 tested or 42 percent contained a herpesvirus morphologically indistinguishable from that originally described by Epstein. Of those derived from normal persons or those with other diseases, 4 of 19 or 21 percent contained a similar herpesvirus. Despite intensive efforts in several laboratories, this virus has not been identified as a known herpesvirus. The term EBV—Epstein-Barr virus—has been suggested as a name for this unidentified herpesvirus strain.
supported by American Cancer Society Grant #E-494.
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Fink, M.A., King, G.S., Mizell, M. (1969). Reactivity of Serum from Frogs and Other Species with a Herpesvirus Antigen Extracted from a Burkitt Lymphoma Cultured Cell Line. In: Mizell, M. (eds) Biology of Amphibian Tumors. Recent Results in Cancer Research, vol 1969. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85791-1_30
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