Tadpole Edema Virus: Pathogenesis and Growth Studies and Additional Sites of Virus Infected Bullfrog Tadpoles

  • Ken Wolf
  • G. L. Bullock
  • C. E. Dunbar
  • M. C. Quimby
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 1969)


Considering geographic origin, method of isolation, and the life stage, health and host species, the polyhedral cytoplasmic amphibian viruses thus far cultured belong to one of three categories. The first category consists of viruses obtained directly from adult Rana pipiens—with or without renal adenocarcinoma—either from northcentral United States or from New England and adjacent Canada (1, 2, 3, 4). The second category comprises viruses from larval or adult Diemictylus viridescens (formerly, Triturus viridescens) from New England or southeastern United States—efts previously inoculated with New England R. pipiens kidney tumor cells (4, 5) and more recently virus has been isolated directly from newts (6). The third category is a group of viruses isolated directly from normal adult or normal and diseased tadpoles of Rana catesbeiana from northcentral or southeastern United States (7).


Leopard Frog Infectious Pancreatic Necrosis Virus Frog Virus Renal Adenocarcinoma Bullfrog Tadpole 
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  1. 1.
    Granoff, A., Came, P. E., and Rafferty, K. A., Jr.: The isolation and properties of viruses from Rana pipiens: Their possible relationship to the renal adenocarcinoma of the leopard frog. Ann. N.Y. Acad. Sci. 126:237–255, 1965.Google Scholar
  2. 2.
    Rafferty, K. A., Jr.: The cultivation of inclusion-associated viruses from Lucke tumor frogs. Ann. N.Y. Acad. Sci. 126:3–21, 1965.PubMedCrossRefGoogle Scholar
  3. 3.
    Granoff, A., Came, P. E., and Breeze, C. D.: Viruses and renal carcinoma of Rana pipiens. I. The isolation and properties of virus from normal and tumor tissue. Virology 29:133–148, 1966.PubMedCrossRefGoogle Scholar
  4. 4.
    Clark, H. F., Brennan, J. C., Zeigel, R. F., and Karzon, D. T.: Isolation and characterization of viruses from the kidneys of Rana pipiens with renal adenocarcinoma before and after passage in the red eft (Triturus viridescens). Jour. Virology 2:629- 640, 1968.Google Scholar
  5. 5.
    Clark, H. F., and Karzon, D. T.: Temperature dependence of growth in cell culture of herpes simplex, vaccinia, and two viruses isolated from amphibia. Fed. Proc. 24:319, 1965.Google Scholar
  6. 6.
    Clark, H. F., Gray, C., Fabian, F., Zeigel, R. F., and Karzon, D. T.: Comparative studies of amphibian cytoplasmic virus strains isolated from the leopard frog, bullfrog and newt, in Biology of Amphibian Tumors (M. Mizell, ed.), Springer-Verlag New York Inc., 1969, pp. 310–326.Google Scholar
  7. 7.
    Wolf, K., Bullock, G. L., Dunbar, C. E., and Quimby, M. C.: Tadpole edema virus: A viscerotropic pathogen for anuran amphibians. J. Inf. Dis. 118:253–262, 1968.CrossRefGoogle Scholar
  8. 8.
    Lehane, D. E., Jr., Clark, H. F., and Karzon, D. T.: Antigenic relationships among frog viruses demonstrated by the plaque reduction and neutralization kinetics tests. Virology 34:590–595, 1968.PubMedCrossRefGoogle Scholar
  9. 9.
    Came, P. E., Geering, G., Old, L. J., and Boyse, E. A.: A serological study of polyhedral cytoplasmic viruses isolated from amphibia. Virology 36:392–400, 1968.PubMedCrossRefGoogle Scholar
  10. 10.
    Wolf, K.: The fish viruses. In Adv. Virus Res. 12:35–101, 1966.Google Scholar
  11. 11.
    Gravell, M., and Malsberger, R. G.: A permanent cell line from the fathead minnow (Pimephales promelas). Ann. N.Y. Acad. Sci. 116: 555–565, 1965.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1969

Authors and Affiliations

  • Ken Wolf
    • 1
  • G. L. Bullock
    • 1
  • C. E. Dunbar
    • 1
  • M. C. Quimby
    • 1
  1. 1.Eastern Fish Disease LaboratoryBureau of Sport Fisheries and WildlifeKearneysvilleUSA

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