Advertisement

Skin Carcinogenesis, Mammals Versus Amphibia

  • Beppino C. Giovanella
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 1969)

Abstract

The successful induction of cancer on the skin by means of topical applications of appropriate chemicals has been known to depend largely on the species employed and on the method of application. Carcinogenesis results in a high percentage of mice when their skins are treated with solutions of polycyclic aromatic hydrocarbons, but much less frequently in rats and rarely in guinea pigs. Only recently have studies been undertaken to try to elucidate the reasons for these profound differences in susceptibility. It was suspected for a long time that the pilosebaceous apparatus was the site of origin of the chemically induced cutaneous cancers. In 1945 Lacassagne and Latarjet (1) found that areas of skin depilated by ultraviolet light irradiation or hairless surgical scars were refractory to carcinogenesis by 3-methylcholanthrene. In 1947 Suntzeff, Carruthers and Cowdry (2) demonstrated that the epidermis of newborn mice, before the appearance of hair follicles, was refractory to a single dose of 3-methylcholanthrene. In 1949 Liang (3) studied the site of origin of cutaneous tumors after application of the same carcinogen by means of an ingenious method of epidermal whole mounting, and localized this site at the junction between the hair follicles and the basal epidermal layer. In 1951 Billingham, Orr and Woodhouse (4) found by epidermal transplantation that interfollicular epithelium treated with carcinogens and transplanted to another site without its hair follicles did not give rise to any tumors, whereas epithelial tumors developed from the area of origin, grafted with untreated epidermis, where the only epithelial structures exposed to the carcinogen were the hair follicles.

Keywords

Polycyclic Aromatic Hydrocarbon Hair Follicle Hairless Mouse Cheek Pouch Skin Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    LaCassagne, A. and Latarjet, R.: Action of methylcholanthrene on certain scars of the skin in mice. Cancer Res. 6:183–188, 1946.Google Scholar
  2. 2.
    Suntzeff, V., Carruthers, C. and Cowdry, E. V.: The role of sebaceous glands and hair follicles in epidermal carcinogenesis. Cancer Res. 7:439–443, 1947.Google Scholar
  3. 3.
    Liang, Hsu-Mu: Localized change in methylcholanthrene-treated epidermis. Cancer Res. 8:211–220, 1948.PubMedGoogle Scholar
  4. 4.
    Billingham, R. E., Orr, J. W. and Woodhouse, D. L.: Transplantation of skin components during chemical carcinogenesis with 20-methylcholanthrene. Brit. J. Cancer 5:416–432, 1951.CrossRefGoogle Scholar
  5. 5.
    Steinmuller, D.: Epidermal transplantation during chemical carcinogenesis: a reinvestigation. Proc. Am. Ass. Cancer Res. 9:66, 1968.Google Scholar
  6. 6.
    Iversen, O. H. and Iversen, U.: A study of epidermal tumorigenesis in the hairless mouse with single and with repeated applications of 3-methylcholanthrene at different dosages. Acta Path. Microbiol. Scand. 62:305–314, 1964.Google Scholar
  7. 7.
    Iversen, U. and Iversen, O. H.: Cycles of hair growth in hairless mice. Acta Path. Microbiol. Scand. 59:50–62, 1967.Google Scholar
  8. 8.
    Giovanella, B. C. and Heidelberger, C.: Studies on the role of the hair follicle in epidermal carcinogenesis. Proc. Am. Ass. Cancer Res. 8:21, 1967.Google Scholar
  9. 9.
    Goshman, L. M. and Heidelberger, C.: Binding of tritium-labeled polycyclic hydrocarbons to DNA of mouse skin. Cancer Res. 27:1678–1688, 1967.PubMedGoogle Scholar
  10. 10.
    Balls, M. and Ruben, L. N.: A review of the chemical induction of neoplasms in amphibia. Experientia 20:241–247, 1964.PubMedCrossRefGoogle Scholar
  11. 11.
    Rous, P. and Smith, W. E.: The neoplastic potentialities of mouse embryo tissues. I. The findings with skin of C. strain embryo transplanted to adult animals. J. Exp. Med. 81:598–619, 1945.CrossRefGoogle Scholar
  12. 12.
    Kleinsmith, L. J. and Pierce, G. B.: Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24:1544–1552, 1964.PubMedGoogle Scholar
  13. 13.
    Foley, G. E. and Drolet, B. P.: Loss of neoplastic properties in vitro. I. Observations with S 180 cell lines. Cancer Res. 24:1461–1467, 1964.PubMedGoogle Scholar
  14. 14.
    Foley, G. E., Handler, A. H., Lynch, P. M., Woolman, S. R., Stulberg, C. S. and Eagle, H.: Loss of Neoplastic Properties in Vitro. II. Observations on K. B. Sublines. Cancer Res. 25: 1254–1261, 1964.Google Scholar
  15. 15.
    Goldstein, M. N., Burdman, J. A. and Journey, L. J.: Long-term tissue culture of neuroblastomas. II. Morphological evidence for differentiation and maturation. J. Nat. Cancer Inst. 32:165–199, 1964.PubMedGoogle Scholar
  16. 16.
    Cushing, H. and Wolbach, S. B.: The transformation of a malignant paravertebral sympathicoblastoma into a benign ganglioneuroma. Am. J. Path. 3:203–216, 1927.PubMedGoogle Scholar
  17. 17.
    Giovanella, B. C., Roller, M. R. and Christenson, R. H.: Biological characteristics of cells from primary hydrocarbon—induced skin carcinomas. Ninth Int. Cancer Congress, 3 6:1966.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1969

Authors and Affiliations

  • Beppino C. Giovanella
    • 1
  1. 1.McArdle Laboratory for Cancer ResearchUniversity of WisconsinMadisonUSA

Personalised recommendations