Skip to main content
SpringerLink
Log in

Immunologic Tolerance and Blood Cell Chimerism in Experimentally Produced Parabiotic Frogs

  • Chapter
Biology of Amphibian Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 1969))

Abstract

In 1951, Anderson, Billingham, Lampkin, and Medawar (1) confidently expected that the interchange of skin grafts between members of pairs of cattle twins would serve to distinguish between twins of monozygotic and those of dizygotic origin. It was not unreasonable to presuppose that tissue reciprocally transplanted between two-egg twins would be victimized by the same host immune response that regularly destroys allografts between siblings of separate births. On the other hand, grafts exchanged between one-egg twins should behave as autografts and survive indefinitely. It came therefore as a curious surprise when these investigators found that dizygotic cattle twins freely accept skin grafts from each other, even when the twin pairs are of unlike sex.

This investigation was supported by grant GM-11782 from the United States Public Health Service.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, D., Billingham, R. E., Lampkin, G. H., and Medawar, P. B.: The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle. Heredity 5:379–398, 1951.

    Article  Google Scholar 

  2. Owen, R. D.: Immunogenetic consequences of vascular anastomoses between bovine twins. Science 102:400–401, 1945.

    Article  PubMed  CAS  Google Scholar 

  3. Billingham, R. E., Brent, L., and Medawar, P. B.: Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Phil. Trans. Roy. Soc. London 2395:3 57–414, 1956.

    Google Scholar 

  4. Billingham, R. E., Brent, L., and Medawar, P. B.: “Actively acquired tolerance” of foreign cells. Nature 172:603–606, 1953.

    Article  PubMed  CAS  Google Scholar 

  5. Billingham, R. E., Brent, L., and Medawar, P. B.: Acquired tolerance of skin homo- grafts. Ann. New York Acad. Sci. 59:409–416, 1955.

    Article  CAS  Google Scholar 

  6. Hasek, M.: Parabiosis in birds during embryonic development. Csl. Biol. 2: 29–31, 1953.

    CAS  Google Scholar 

  7. Hasek, M.: Vegetative hybridization of animals by means of junction of blood circulation during embryonic development. Csl. Biol. 2:267–282, 1953.

    CAS  Google Scholar 

  8. Brent, L., and Gowland, G.: Cellular dose and age of host in the induction of tolerance. Nature 192:1265–1267, 1961.

    Article  PubMed  CAS  Google Scholar 

  9. Guttman, R. D., and Aust, J. B.: Acquired tolerance to homografts produced by homologous spleen cell injection in adult mice. Nature 192: 564–565, 1961.

    Article  Google Scholar 

  10. Shapiro, F., Martinez, C., Smith, J. M., and Good, R. A.: Tolerance of skin homografts induced in adult mice by multiple injections of homologous spleen cells. Proc. Soc. Exp. Biol. Med. 106:472–475, 1961.

    Google Scholar 

  11. Billingham, R. E., and Silvers, W. K.: Some factors that determine the ability of cellular inocula to induce tolerance of tissue homografts. J. Cell, and Comp. Physiol. 60 (suppl.): 183–200, 1962.

    Article  Google Scholar 

  12. Volpe, E. P., and Gebhardt, B. M.: Evidence from cultured leucocytes of blood cell chimerism in exparabiotic frogs. Science 1 54:1197–1198, 1966.

    Article  Google Scholar 

  13. Volpe, E. P., and Gebhardt, B. M.: Chimerism of bone marrow cells in exparabiotic frogs. Exp. Cell. Res. 49:194–229, 1968.

    Article  PubMed  CAS  Google Scholar 

  14. Volpe, E. P., and Curtis, S.: Germ cell chimerism: absence in parabiotic frogs. Science 160:328–329, 1968.

    Article  PubMed  CAS  Google Scholar 

  15. Born, G.: Über verwachsungsversuche mit amphibienlarven. Arch. Entwicklungsmech Organ 4:349–465, 517–623, 1897.

    Article  Google Scholar 

  16. Shumway, W.: Stages in the normal development of Rana pipiens. I. External form. Anat. Record 78:139–144, 1940.

    Article  Google Scholar 

  17. Volpe, E. P.: Fate of neural crest homotransplants in pattern mutants of the leopard frog. J. Exp. Zool. 2 57:179–196, 1964.

    Article  Google Scholar 

  18. Volpe, E. P., and Gebhardt, B. M.: Effect of dosage on the survival of embryonic homo- transplants in the leopard frog, Rana pipíens. J. Exp. Zool. 160:11–28, 1965.

    Article  PubMed  CAS  Google Scholar 

  19. Dasgupta, S.: Induction of triploidy by hydrostatic pressure. J. Exp. Zool. 151:105–116, 1962.

    Article  PubMed  CAS  Google Scholar 

  20. Tips, R. L., Smith, G., Meyer, D. L., and Ushijima, R. N.: Karyotype analysis of leucocytes as a practical laboratory procedure. Texas Rept. Biol. Med. 21:581–586, 1963.

    CAS  Google Scholar 

  21. Moorhead, P. S., Nowell, P. C., Mellman, W. J., Batipps, D. M., and Hungerford, D. A.: Chromosome preparations of leucocytes cultured from peripheral blood. Exptl. Cell. Res. 20:613–616, 1960.

    Article  PubMed  CAS  Google Scholar 

  22. Saksela, E., and Moorhead, P. S.: Enhancement of secondary constrictions and the heterochromatic X in human cells. Cytogenetics 1:225–244, 1962.

    Article  PubMed  CAS  Google Scholar 

  23. Owen, R. D., Davis, H. P., and Morgan, R. F.: Quintuplet calves and erythrocyte mosaicism. J. Hered. 37:291–297, 1947.

    Google Scholar 

  24. Mange, A. P., and Stone, W. H.: A spectrophotometry technique for measuring erythrocyte chimerism in cattle. Proc. Soc. Exp. Biol. Med. 102:107–110, 1959.

    PubMed  CAS  Google Scholar 

  25. Stone, W. H., Berman, D. T., Tyler, W. J., and Irwin, M. R.: Blood types of the progeny of a pair of cattle twins showing erythrocyte mosaicism. J. Hered. 51:136–140, 1960.

    Google Scholar 

  26. Stone, W. H., Cragle, R. G., Swanson, E. W., and Brown, D. G.: Skin grafts: delayed rejection between pairs of cattle twins showing erythrocyte chimerism. Science 148: 1335–1336, 1965.

    Article  PubMed  CAS  Google Scholar 

  27. Hasek, M.: Abolition of tolerance of skin heterografts by means of serum antibodies. Folia Biol. (Prague) 8:57, 1962.

    CAS  Google Scholar 

  28. Edwards, J. H.: Chromosome analysis from capillary blood. Cytogenetics 1:90–96, 1962.

    Article  Google Scholar 

  29. Jordan, H. E., and Speidel, C. C: Studies on lymphocytes. 1. Effect of splenectomy, experimental hemorrhage and a hemolytic toxin in the frog. Am. J. Anat. 32:155–188, 1923.

    Article  Google Scholar 

  30. Jordan, H. E., and Speidel, C. C.: Blood cell formation and distribution in relation to the mechanism of thyroid-accelerated metamorphosis in the larval frog. J. Exp. Med. 28:529–542, 1923.

    Article  Google Scholar 

  31. Foxon, G. E. H.: Blood and respiration. In Physiology of the Amphibia (J. A. Moore, ed.), Academic Press, New York, 1 51–209, 1964.

    Google Scholar 

  32. Frieden, E.: Biochemical adaptation and anuran metamorphosis. Am. Zoologist 1:115–149, 1961.

    Google Scholar 

  33. Baglioni, C, and Sparks, C. E.: A study of hemoglobin differentiation in Rana catesbeiana. Develop. Biol. 8:272–28 5, 1963.

    Google Scholar 

  34. Moss, R., and Ingram, V. M.: The repression and induction by thyroxin of haemoglobin synthesis. Proc. Natl. Acad. Sci. (U.S.) 54:967–974, 1965.

    Article  CAS  Google Scholar 

  35. Hollyfield, J. G.: Erythrocyte replacement at metamorphosis in the frog, Rana pipiens. J. Morph. 119:1–6, 1966.

    Article  PubMed  CAS  Google Scholar 

  36. Nakic, B., Teplitz, R. L., and Ohno, S.: Cytological analysis of parabiotic disease in mice. Transplantation 4:22–31, 1966.

    Article  Google Scholar 

  37. Stone, W. H., Friedman, J., and Fregin, A.: Possible somatic cell mating in twin cattle with erythrocyte mosaicism. Proc. Natl. Acad. Sci. (U.S.) 51:1036–1044, 1964.

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Bryan M. Gebhardt

    Present address: Department of Pathology, University of Florida, Gainesville, Florida, USA

  2. Sherill Curtis

    Present address: Department of Biology, University of Denver, Denver, Colorado, USA

Authors and Affiliations

  1. Department of Biology, Tulane University, New Orleans, Louisiana, USA

    E. Peter Volpe, Bryan M. Gebhardt, Sherill Curtis & Elizabeth M. Earley

Authors
  1. E. Peter Volpe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bryan M. Gebhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sherill Curtis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elizabeth M. Earley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biology, Tulane University, New Orleans, Louisiana, USA

    Merle Mizell

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Volpe, E.P., Gebhardt, B.M., Curtis, S., Earley, E.M. (1969). Immunologic Tolerance and Blood Cell Chimerism in Experimentally Produced Parabiotic Frogs. In: Mizell, M. (eds) Biology of Amphibian Tumors. Recent Results in Cancer Research, vol 1969. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85791-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85791-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85793-5

  • Online ISBN: 978-3-642-85791-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation