Aging — Still a Mystery

  • R. Zwilling
Part of the Reihe der Villa Vigoni book series (VILLA VIGONI, volume 1)


Aging is one of the most intriguing and least understood phenomenon in modern biology. Nonetheless, it is present everywhere around us — and it is in us. Man has always followed with amazed curiosity and emotional interest the changes accompanying birth, development, aging, and death. And human beings date back to the very day when they became aware of aging and death and started to bury the dead. But superstition and ignorance also have always obscured the occurrence of aging and Christoph Wilhelm Hufeland, who wrote the medical bestseller of the 18th century (“On the Art of Prolonging Human Live”, 1796 [1], rightly stated:

“This problem has always been a favorite of the keenest minds, a playground for daydreamers, and the main enticement for charlatans and swindlers.”


Life Span Multicellular Organism Biological Clock Werner Syndrome Error Catastrophe 
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  1. 1.
    Hufeland, CW (1798) Die Kunst das menschliche Leben zu verlängern. Akademische Buchhandlung, JenaGoogle Scholar
  2. 2.
    Weismann, A (1884) Über Leben und Tod. JenaGoogle Scholar
  3. 3.
    Goethe, JW von (1783) Fragment „Die Natur”, Tiefurter JournalGoogle Scholar
  4. 4.
    Wood, WB (1988) The nematode Caenorhabditis elegans. Cold Spring Harbor Laboratory , Cold Spring HarborGoogle Scholar
  5. 5.
    Reichel, W et al (1971) Progeria and Werner’s syndrome as models for the study of normal human aging. J Am Geriatric Soc 19: 369–375Google Scholar
  6. 5.
    Dayhoff, MO (1972) Atlas of Protein Sequence and Structure Vol. 5, National Biomedical Res. Found., Washington, D.C.Google Scholar
  7. 7.
    Orgel, LE (1970) The maintenance of the accuracy of protein synthesis and its relevance to ageing: a correlation. Proc Natl Acad Sci USA 67: 1476PubMedCrossRefGoogle Scholar
  8. 8.
    Curtis, HJ (1968) Das Altern — die biologischen Vorgänge. Gustav Fischer, StuttgartGoogle Scholar
  9. 9.
    Hayflick, L (1980) The cell biology of human aging. Sci Am 242: 58–65PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1992

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  • R. Zwilling

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