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Molecular Requirements for Synthetic RNA to Act in Interferon Stimulation

  • Thomas C. Merigan
  • Erik De Clercq
  • Fritz Eckstein
  • Robert D. Wells

Abstract

Three varieties of polyanions have been associated with interferon production; that is, plastics, polysaccharides, and polynucleotides (reviewed by De Clercq and Merigan, 1970). Only with the latter do we have any knowledge of three-dimensional structure, due to the work of Watson and Crick (1953), Wilkins et al. (1953), and others as reviewed by Davies (1967). Knowledge of the genetic role of nucleic acids in the last 2 decades has led to an immense amount of chemical information on their structure and synthesis. However, proteins are the biologically important macromolecules about which most is known as to mechanisms on the organic chemical level which underly their activities. Here, it is quite clear that in contrast to the limited knowledge provided by information on primary sequence, major insights were afforded only by precise descriptions of the three-dimensional structure of proteins (Barnard, 1969). Therefore, we have been attracted to study the structural requirements and fate of nucleotides acting as interferon inducers in the cell, because of the potential for meaningful molecular level understanding of this phenomenon. As this represents a new function for nucleic acids, it is possible that the structural basis of this activity may even have implications for nucleic acid structure and genetic function.

Keywords

Antiviral Activity Vesicular Stomatitis Virus Human Skin Fibroblast Interferon Production Stable Secondary Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1971

Authors and Affiliations

  • Thomas C. Merigan
    • 1
    • 2
    • 3
  • Erik De Clercq
    • 1
    • 2
    • 3
  • Fritz Eckstein
    • 1
    • 2
    • 3
  • Robert D. Wells
    • 1
    • 2
    • 3
  1. 1.Division of Infectious Diseases, Department of MedicineStanford University Medical SchoolStanfordUSA
  2. 2.Max-Planck-Institut für Experimentelle MedizinAbteilung ChemieGöttingenWest Germany
  3. 3.Department of BiochemistryUniversity of WisconsinMadisonUSA

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