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Double-Stranded RNA’s in Relation to Interferon Induction and Adjuvant Activity

  • Maurice R. Hilleman
  • George P. Lampson
  • Alfred A. Tytell
  • A. Kirk Field
  • Marjorie M. Nemes
  • Irwin H. Krakoff
  • Charles W. Young

Abstract

The conduct of research in the medical sciences finds ample justification and support when it is targeted at an applied objective—that of producing something useful. New phenomena are eagerly sought that can be developed toward such an end. Hoskins’ (1935) discovery of the interference phenomenon is one such example, and its exciting possibilities were increasingly realized as its broad-spectrum antiviral nature was revealed. The epic discovery by Isaacs and Lindenmann (1957) of the protein mediator of interference, that is interferon, raised immediate hope for direct application to man but this has been subdued to date by problems of production and economic considerations (Hilleman, 1965; Ho and Postic, 1967; Merigan, 1967; Hilleman, 1968). The logical development, therefore, was the search for suitable inducers whereby the body could be stimulated to produce and distribute its own interferon. Early attack on the problem provided an abundance of inducers (Finter, 1966; Merigan and Regelson, 1967; Regelson, 1967) but none was of practical value because of infectiousness, extreme toxicity, antigenicity, and the like.

Keywords

Host Resistance Yellow Fever Virus Influenza Virus Vaccine Interferon Induction Penicillium Funiculosum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1971

Authors and Affiliations

  • Maurice R. Hilleman
    • 1
    • 2
  • George P. Lampson
    • 1
    • 2
  • Alfred A. Tytell
    • 1
    • 2
  • A. Kirk Field
    • 1
    • 2
  • Marjorie M. Nemes
    • 1
    • 2
  • Irwin H. Krakoff
    • 1
    • 2
  • Charles W. Young
    • 1
    • 2
  1. 1.Division of Virus and Cell Biology ResearchMerck Institute for Therapeutic ResearchWest PointUSA
  2. 2.Sloan-Kettering Institute for Cancer ResearchThe Memorial HospitalNew YorkUSA

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