Immunity and Tolerance to Synthetic Polynucleotides in New Zealand Mice
Our laboratory has been studying the pathogenesis of the autoimmune disorder systemic lupus erythematosus as it occurs in humans and in the inbred New Zealand mice. The disease in both species is characterized by spontaneous formation of antibodies to double-stranded DNA and RNA which unite with antigen, fix complement, and deposit in the kidney where the immune complexes lead to a fatal glomerulonephritis. Three factors contribute to this disorder. These factors are genetic, immunologic, and viral.
KeywordsSystemic Lupus Erythematosus Immunologic Tolerance Lymphocytic Choriomeningitis Polycytidylic Acid Bovine Gamma Globulin
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