Immunity and Tolerance to Synthetic Polynucleotides in New Zealand Mice

  • Norman Talal
  • Alfred D. Steinberg
Conference paper

Abstract

Our laboratory has been studying the pathogenesis of the autoimmune disorder systemic lupus erythematosus as it occurs in humans and in the inbred New Zealand mice. The disease in both species is characterized by spontaneous formation of antibodies to double-stranded DNA and RNA which unite with antigen, fix complement, and deposit in the kidney where the immune complexes lead to a fatal glomerulonephritis. Three factors contribute to this disorder. These factors are genetic, immunologic, and viral.

Keywords

Arthritis Albumin Leukemia Interferon Cyclophosphamide 

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References

  1. Pincus, T., Schur, P. H., Rose, J. A., Decker, J. L., and Talal, N. (1969). Measurement of serum DNA-binding activity in systemic lupus erythematosus. New England J. Med. 281: 701–705.CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag New York Inc. 1971

Authors and Affiliations

  • Norman Talal
    • 1
  • Alfred D. Steinberg
    • 1
  1. 1.Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic DiseasesNational Institutes of HealthBethesdaUSA

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