Immunity and Tolerance to Synthetic Polynucleotides in New Zealand Mice

Talal, Norman; Steinberg, Alfred D.

doi:10.1007/978-3-642-85772-0_16

Norman Talal³ &
Alfred D. Steinberg³

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Abstract

Our laboratory has been studying the pathogenesis of the autoimmune disorder systemic lupus erythematosus as it occurs in humans and in the inbred New Zealand mice. The disease in both species is characterized by spontaneous formation of antibodies to double-stranded DNA and RNA which unite with antigen, fix complement, and deposit in the kidney where the immune complexes lead to a fatal glomerulonephritis. Three factors contribute to this disorder. These factors are genetic, immunologic, and viral.

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References

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Authors and Affiliations

Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, USA
Norman Talal & Alfred D. Steinberg

Authors

Norman Talal
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Alfred D. Steinberg
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Editors and Affiliations

Johns Hopkins University, Baltimore, Maryland, USA
Roland F. Beers Jr.
Rutgers University, New Brunswick, New Jersey, USA
Werner Braun

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Talal, N., Steinberg, A.D. (1971). Immunity and Tolerance to Synthetic Polynucleotides in New Zealand Mice. In: Beers, R.F., Braun, W. (eds) Biological Effects of Polynucleotides. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85772-0_16

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DOI: https://doi.org/10.1007/978-3-642-85772-0_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-85774-4
Online ISBN: 978-3-642-85772-0
eBook Packages: Springer Book Archive

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