Conversion with Polynucleotides of a Genetically Controlled Low Immune Response to a High Response in Mice Immunized with a Synthetic Polypeptide Antigen
During the past few years a number of investigations have demonstrated that genetics plays a significant role in the ability of several animal species to elicit immune responses to a variety of antigens (McDevitt and Benacerraf, 1969). Results of experiments using synthetic polypeptides of restricted heterogeneity indicated that antibody responses of mice to these types of immunogens were controlled by dominant, quantitative, autosomal genes (McDevitt and Sela, 1965, 1967; Pinchuck and Maurer, 1968; Mozes et al., 1969 a, 1969 b). In view of the complexity of the cellular events involved in immune processes, it is possible that certain genetic controls are expressed at the cellular level. Hence, genetic controls could affect any of a number of cell-mediated steps.
KeywordsAlbumin Agar Polypeptide Erythro Polynucleotide
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- Braun, W. (1969). Proc. VIth Inter. Congress of Chemotherapy, Tokyo.Google Scholar
- Braun, W. (1970). In Aging, Autoimmunity and Tolerance. Charles C. Thomas, Springfield.Google Scholar
- Braun, W., Yajima, Y., Jimenez, L., and Winchurch, R. (1970). In Developmental Aspects of Antibody Formation and Structure. Academic Press, New York.Google Scholar
- Jerne, N. K., Nordin, A. A., and Henry, C. (1963). The agar plaque technique for recognizing antibody-producing cells. In Cell-bound Antibodies. 109–116. The Wistar Institute Press, Philadelphia.Google Scholar
- Johnson, H. G. and Johnson, A. G. (1968). Bact. Proc. 75. Google Scholar
- Mozes, E., Shearer, G. M., and Sela, M. (1970). Cellular basis of the genetic control of immune responses to synthetic polypeptides. I. Differences in frequency of splenic precursor cells specific for a synthetic polypeptide derived from multichain polyproline, (T, G)-Pro—L, in High and low responder inbred mouse strains. J. Exp. Med. (In press).Google Scholar
- Pinchuk, P. and Maurer, P. H. (1968). Genetic control of aspects of the immune response. In Regulation of the Antibody Response. 97–113. Charles C. Thomas, Springfield.Google Scholar