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The Molecular Basis of the Interaction of Immunoglobulin G with Complement and Phagocytic Cells

  • D. R. Burton
Conference paper
Part of the NATO ASI Series book series (volume 24)

Abstract

The elimination of bacterial cells mediated by antibodies involves the antibody molecule in a dual recognition process. First, the antibody recognizes foreign antigenic determinants on the bacterial cell surface. Second, the antibody-coated bacterial cell is recognized by an effector molecule, such as complement C1q or cellular Fc receptor, triggering effector mechanisms, such as complement or phagocytosis, leading to elimination of the bacterial cell. The molecular basis of the interaction of antibody and antigen is reasonably well understood. Recently, the crystallographic structure of the complex of the Fab fragment of an anti-lysozyme antibody with lysozyme has been described (Amit et al, 1986). In contrast, the basis for the interaction of antibody and effector molecules is only now being tackled at the molecular level.

Keywords

Effector Molecule United Kingdom Introduction Foreign Antigenic Determinant Heavy Chain Dimerization Yorkshire Cancer Research Campaign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. R. Burton
    • 1
  1. 1.Department of BiochemistryUniversity of SheffieldSheffieldUK

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