The Molecular Basis of the Interaction of Immunoglobulin G with Complement and Phagocytic Cells
The elimination of bacterial cells mediated by antibodies involves the antibody molecule in a dual recognition process. First, the antibody recognizes foreign antigenic determinants on the bacterial cell surface. Second, the antibody-coated bacterial cell is recognized by an effector molecule, such as complement C1q or cellular Fc receptor, triggering effector mechanisms, such as complement or phagocytosis, leading to elimination of the bacterial cell. The molecular basis of the interaction of antibody and antigen is reasonably well understood. Recently, the crystallographic structure of the complex of the Fab fragment of an anti-lysozyme antibody with lysozyme has been described (Amit et al, 1986). In contrast, the basis for the interaction of antibody and effector molecules is only now being tackled at the molecular level.
KeywordsEffector Molecule United Kingdom Introduction Foreign Antigenic Determinant Heavy Chain Dimerization Yorkshire Cancer Research Campaign
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