Biogenesis of Galα(1–4)Gal binding P-pili of Uropathogenic E. Coli

  • Monica Båga
  • Kristina Forsman
  • Mikael Göransson
  • Frederik Lindberg
  • Björn Lund
  • Britt-Inger Marklund
  • Mari Norgren
  • Staffan Normark
  • Jan Tennent
  • Bernt Eric Uhlin
Conference paper
Part of the NATO ASI Series book series (volume 24)

Abstract

Escherichia coli is the most common cause of urinary tract infections (UTI). Depending on the virulence of the organism and the efficiency of the host defense system, these UTI appear either as asymptomatic bacteriuria, acute cystitis or acute pyelonephritis. A number of putative virulence properties have been recognized in E. coli isolates associated with acute pyelonephritis in otherwise uncompromised children. One such property is the ability to express mannose-resistant (MR) hemagglutinins. Most E. coli are capable of forming type 1 pili that carry a mannosespecific adhesin. Pyelonephritogenic E. coli additionally carry one or more chromosomal gene clusters that encode pili associated with MR hemagglutination. Of the several MR hemagglutinins that are known today, the best characterized is the Galα(1–4)Gal-specific adhesin associated with P-pili. The name P-pili refers to the observation that this adhesin acts as a hemagglutinin for erythrocytes which express any of the P blood group antigens.

Keywords

Carboxyl Proline Half Life Hull Lysozyme 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Monica Båga
    • 1
  • Kristina Forsman
    • 1
  • Mikael Göransson
    • 1
  • Frederik Lindberg
    • 1
  • Björn Lund
    • 1
  • Britt-Inger Marklund
    • 1
  • Mari Norgren
    • 1
  • Staffan Normark
    • 1
  • Jan Tennent
    • 1
  • Bernt Eric Uhlin
    • 1
  1. 1.Department of MicrobiologyUniversity of UmeåUmeåSweden

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