The Role of Axonal Transport in the Growth of the Olfactory Nerve Axons
Numerous studies have analyzed changes in axonal transport that accompany nerve regeneration. These investigations have generally been carried out in vertebrate peripheral nerve or in lower vertebrate optic nerve, systems in which nerve injury is followed by rapid distal degeneration and regrowth of injured axons. (For review: see Graf stein and McQuarrie .) Findings to date have included changes in the amount and composition of rapidly transported molecules and changes in both rate of transport and composition of slowly transported molecules [6, 9, 14]. The significance of the observed changes in facilitating the processes of axonal outgrowth and functional reconnection is still poorly understood.
KeywordsAxonal Transport Nerve Regeneration Slow Flow Olfactory Nerve Olfactory Neuron
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- 6.Giulian D, Des Ruisseaux H, Cowburn D (1980) Biosynthesis and intraaxonal transport of proteins during neuronal regeneration. J Biol Chem 255: 6469–6501Google Scholar
- 7.Grafstein B, McQuarrie IG (1978) Role of nerve cell body in axonal regeneration. In: Cotman CW (ed) Neuronal plasticity. Raven Press, New York, pp 155–195Google Scholar
- 8.Graziadei PPC, Moti-Graziadei GA (1978) Continuous nerve cell renewal in the olfactory system. In: Jacobson M (ed) Handbook of sensory physiology, vol IX: Development of sensory systems. Springer, Berlin Heidelberg New York, pp 55–82Google Scholar
- 11.McQuarrie IG, Grafstein B (1978) Protein synthesis and fast transport in regenerating goldfish retinal ganglion cells: effect of a conditioning lesion. Soc Neurosci Abstr 4: 533Google Scholar
- 15.Small KR, Pfenninger KH (1980) Properties and maturation of axolemma in growing neurons. Soc Neurosci Abstr 6:661Google Scholar