Disturbances of Axoplasmic Transport in Alzheimer’s Disease

  • Pierre Dustin
  • Jacqueline Flament-Durand
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


In Alzheimer’s disease, and in a small group of other neurological disorders, the normal microtubules and neurofilaments are replaced or displaced by an accumulation of so-called“paired helical filaments” (PHF) which are parallel oriented structures, periodically twisted every 80 nm. In light microscopy, they form the so-called“tangles” in the neuronal perikarya which stain with silver methods and show a strong birefringence with a green dichroism after Congo Red staining. This property is similar to that of amyloid and has led some authors to the false conclusion that these tangles represent intracellular deposits of amyloid.


Ethyl Dementia Polypeptide Neurol Paraffin 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Pierre Dustin
  • Jacqueline Flament-Durand
    • 1
  1. 1.Department of Pathology and Electron MicroscopyUniversité Libre de BruxellesBrusselsBelgium

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