Disturbances of Axoplasmic Transport in Alzheimer’s Disease

  • Pierre Dustin
  • Jacqueline Flament-Durand
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

In Alzheimer’s disease, and in a small group of other neurological disorders, the normal microtubules and neurofilaments are replaced or displaced by an accumulation of so-called“paired helical filaments” (PHF) which are parallel oriented structures, periodically twisted every 80 nm. In light microscopy, they form the so-called“tangles” in the neuronal perikarya which stain with silver methods and show a strong birefringence with a green dichroism after Congo Red staining. This property is similar to that of amyloid and has led some authors to the false conclusion that these tangles represent intracellular deposits of amyloid.

Keywords

Ethyl Dementia Polypeptide Neurol Paraffin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    De Boni U, Crapper DR (1978) Paired helical filaments of the Alzheimer type in cultured neurones. Nature (London) 271: 566–568CrossRefGoogle Scholar
  2. 2.
    Dubois-Dalcq M, Worthinton K, Gutenson O, Barbosa LH (1975) Immunoperoxidase labelling of subacute sclerosing panencephalitis virus in hamster acute encephalitis. Lab Invest 32: 518–526PubMedGoogle Scholar
  3. 3.
    Dustin P, Flament-Durand J, Vandermot G (1979) Aspects ultrastructuraux du viellissement cérébral. Bull Mém Acad R Med Belg 134: 369–383PubMedGoogle Scholar
  4. 4.
    Dziedzic JD, Iqbal K, Wisniewski HM (1980) Central cholinergic activity in Alzheimer dementia. J Neuropathol Exp Neurol 39: 351CrossRefGoogle Scholar
  5. 5.
    Glenner GG (1980) Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med 302: 1283–1292, 1333-1343PubMedCrossRefGoogle Scholar
  6. 6.
    Iqbal K, Grundke-Iqbal I, Wisniewski HM, Terry RD (1978) Neurofibers in Alzheimer dementia and other conditions. In: Katzman R, Terry RD, Bick KL (eds) Alzheimer’s disease, senile dementia and related disorders. Raven Press, New York, pp 409–420Google Scholar
  7. 7.
    Iqbal K, Grundke-Iqbal I, Johnson AB, Wisniewski HM (1979) Are neurotubule proteins involved in the formation of Alzheimer neurofibrillary tangles? J Neuropathol Exp Neurol 38: 322CrossRefGoogle Scholar
  8. 8.
    Iqbal K, Grundke-Iqbal I, Johnson AB, Wisniewski HM (1980) Neurofibrous proteins in aging and dementia. In: Amaducci L, Davison AN, Antuono P (eds) Aging of the brain and dementia. Raven Press, New York, pp 39–48Google Scholar
  9. 9.
    Ishii T, Haga S, Tokutake S (1979) Presence of neurofilament protein in Alzheimer’s neurofibrillary tangles (ANT). An immunofluorescent study. Acta Neuropathol 48: 105–112PubMedCrossRefGoogle Scholar
  10. 10.
    Knox CA, Yates RD, Chen IL (1980) Brain aging in normotensive and hypertensive strains of rats. II. Ultrastructural changes in neurons and glia. Acta Neuropathol 52: 7–16PubMedCrossRefGoogle Scholar
  11. 11.
    Linder E, Lehto V-P, Virtanen I (1979) Amyloid-like green birefringence in cytoskeletal 10 nm filaments after staining with Congo Red. Acta Pathol Microbiol Scand 87: 299–306Google Scholar
  12. 12.
    Luse SA, Smith KR Jr (1964) The ultrastructure of senile plaques. Am J Pathol 44: 553–563PubMedGoogle Scholar
  13. 13.
    Mandybur TI, Nagpaul AS, Pappas Z, Niklowitz WJ (1977) Alzheimer neurofilbrillary changes in subacute sclerosing panencephalitis. Ann Neurol 1: 103–107PubMedCrossRefGoogle Scholar
  14. 14.
    Selkoe DJ (1980) Altered protein composition of isolated human cortical neurons in Alzheimer disease. Ann Neurol 8: 468–478PubMedCrossRefGoogle Scholar
  15. 15.
    Terry RD (1963) The fine structure of the neurofibrillary tangles in Alzheimer’s disease. J Neuropathol Exp Neurol 22: 629–642PubMedCrossRefGoogle Scholar
  16. 16.
    Volk B (1980) Paired helical filaments in rat spinal ganglia following chronic alcohol administration: an electron microscopic investigation. Neuropathol Appl Neurobiol 6: 143–153PubMedCrossRefGoogle Scholar
  17. 17.
    Wisniewski HM, Iqbal K (1980) Aging of the brain and dementia. Trends Neurosci 3: 226–228Google Scholar
  18. 18.
    Wisniewski HM, Ghetti B, Terry RDJ (1973) Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 32: 566–584PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Pierre Dustin
  • Jacqueline Flament-Durand
    • 1
  1. 1.Department of Pathology and Electron MicroscopyUniversité Libre de BruxellesBrusselsBelgium

Personalised recommendations