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Pharmacology of T and L Type Ca2+ Channels in Cardiac Tissue

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Antiarrhythmic Drugs

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Abstract

There exist two types of voltage gated Ca channels in cardiac cells [1–3]. The literature describing the biophysics and physiology of these channels, the L type Ca channel (iCaL) and the T type Ca channel (iCat), is vast. It is not the intent of this chapter to review this exhaustive literature; however, initially we describe some of the physiological and biophysical facts essential for the study of channel pharmacology. On the other hand, the literature describing the pharmacology of these two cardiac Ca channels is limited, particularly in reference to the pharmacology of the T type channel. Therefore, the emphasis here is to discuss the known pharmacology of both channels with particular attention to the T type Ca channel.

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Authors
  1. P. A. Boyden
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  2. G.-N. Tseng
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Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Innere Medizin C, Westfälische Wilhelms-Universität Münster, Albert-Schweitzer-Straße 33, D-48129, Münster, Germany

    Günter Breithardt , Wilhelm Haverkamp  & Gerhard Hindricks ,  & 

  2. Dept. of Cardiological Sciences, St. George’s Hospital Medical School Cranmer Terrace, SW17 ORE, London, UK

    A. John Camm

  3. Department of Medicine, O’Connor Hospital, 2100 Forest Avenue, Suite 110, 95128, San Jose, CA, USA

    Mohammad Shenasa

  4. Department of Cardiology and Angiology, Westfälische Wilhelms-Universität Münster, Albert-Schweitzer-Straße 33, D-48129, Münster, Germany

    Martin Borggrefe

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© 1995 Springer-Verlag Berlin Heidelberg

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Boyden, P.A., Tseng, GN. (1995). Pharmacology of T and L Type Ca2+ Channels in Cardiac Tissue. In: Breithardt, G., Borggrefe, M., Camm, A.J., Shenasa, M., Haverkamp, W., Hindricks, G. (eds) Antiarrhythmic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85624-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-85624-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85626-6

  • Online ISBN: 978-3-642-85624-2

  • eBook Packages: Springer Book Archive

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