Zusammenfassung
Aldosteron kann an der Pathogenese verschiedener Formen von experimentellem und von klinischem Hochdruck in folgender Weise beteiligt sein:
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1.
Als primär auslösende Noxe, entweder durch endogene Überproduktion oder in Form exogener Überdosierung. Dabei kann neben anderen Symptomen ein Hochdruck auftreten, vorausgesetzt, daß bestimmte Versuchsbedingungen eingehalten werden.
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2.
Als sekundärer Faktor im Sinne einer permissiven Wirkung, wobei die Anwesenheit normaler Mengen von Aldosteron genügt, um zusammen mit anderen humoralen Faktoren die Voraussetzungen für die Entwicklung oder Aufrechterhaltung eines Hochdruckes zu geben.
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Literatur
August, J. H., D. H. Nelson and G. W. Thorn: Response of normal subjects to large amounts of aldosterone. J. clin. Invest. 37, 1459 (1958).
August, J. H., D. H. Nelson and G. W. Thorn: Adjustment to aldosterone or desoxycorticosterone acetate induced sodium retention in patients with ADDISON’S disease. J. clin. Invest. 38, 1964 (1959); Metabolism 9, 508 (1960).
Bartter, F. C., A. G. T. Casper, C. S. Delea and J. D. H. Slater: On the role of the kidney in control of adrenal steroid production. Metabolism 10, 1006 (1961).
Besch, P. K., K. A. Brownell, F A Hartman and D. J. Watson: Adrenocortical steroid profile in the hypertensive dog. Acta endocr. (Kbh.) 39, 355 (1962).
Brodi, M. P., and C. Pellegrino: The secretion of corticosterone and aldosterone by the rat adrenal cortex regenerating after enucleation. J. Physiol. (Lond.) 146, 165 (1959).
Carpenter, C. C. J., J. O. Davis and C. R. Ayers: Relation of renin, angiotensin II, and experimental renal hypertension to aldosterone secretion. J. clin. Invest. 40, 2026 (1961).
Chappel, C. I., G. Rona and J. Cahill: Studies on the pathogenesis of adrenal-regeneration hypertension in the rat. Arch. Path. 65, 636 (1958).
Comparison of corticosterone and adrenal-regeneration hypertension. Proc. Canad. Fed. Biol. Soc. 1958, p. 12.
Cope, C. L., M. Harwood and J. Pearson: Aldosterone secretion in hypertensive disease. Brit. med. J. 1962 I, 659.
Davignon, J., E. Koiw, W. Nowaczynski, G. Tremblay and J. Genest: Studies on the in vitro production of corticosteroids by adrenal glands from normotensive individuals and hypertensive patients. Canad. J. Biochem. 40, 285 (1962).
Davis, J. O., C. C. J. Carpenter, C. R. Ayers, J. E. Holman and R. C. Bahn: Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J. clin. Invest. 40, 684 (1961).
Davis P. M. Hartroft, E. O. Titus, C. C. J. Carpenter, C. R. Ayers and H. E. Spiegel: The role of the renin-angiotensin system in the control of aldosterone secretion. J. clin. Invest. 41, 378 (1962).
Fregly, M. J.: Production of hypertension in adrenalectomized rats given hypertonic salt solution to drink. Endocrinology 66, 240 (1960).
Fregly, M. J. and V. M. Arean: Comparison of the effects of aldosterone and desoxycorticosterone acetate on blood pressure of rats. Acta physiol. pharmacol. neerl. 8, 162 (1959).
Gaunt, R., G. J. Ulsamer and J. J. Chart: Aldosterone and hypertension. Arch. int. Pharmacodyn. 110, 114, (1957).
Gaunt F. Gross, A. A. Renzi and J. J. Chart: The adrenal cortex in hypertension (with particular reference to adrenal regeneration hypertension). “Hypertension”. 1st Hahnemann Symposium on Hypertensive Disease, p. 219. Philadelphia: Saunders 1959.
Genest, J., W. Nowaczynski, E. Koiw, T. SANDOR and P. BIRON: Nebennierenrindenfunktion bei essentieller Hypertonie. „Essentielle Hypertonie“, p. 143. Berlin, Göttingen, Heidelberg: Springer 1960.
Genest, J., W. Nowaczynski, E. Koiw, T. SANDOR and P. BIRON: Angiotensin, aldosterone and human arterial hypertension. Canad. med. Ass. J. 84, 403 (1961).
Genest, J. P. BIRON, R. BOUCHER, E. KOIw, W. NOWACZYNSKI and M. CHRÉTIEN: Hypertension and the endocrine system. “Hypertension, recent advances.” 2nd Hahnemann Symposium on Hypertensive Disease, p. 76. Philadelphia: Lea Febiger 1961.
Goldblatt, H.: The renal origin of hypertension. Physiol. Rev. 27, 120 (1947).
Gornall, A. G., R. Nakashima, H. M. Grundy, C. J. Koladich and M. V. L. Rao: Further studies of aldosterone induced hypertension in rats. Proc. Endocrin. Soc., 39th Meet. 1957, p. 15.
Gross, F.: Experimentelle Methoden zur Beurteilung blutdrucksenkender Pharmaka. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 232, 161 (1957).
Gross, F.: Renin und Hypertensin, physiologische oder pathologische Wirkstoffe ? Klin Wschr. 36, 693 (1958).
Gross, F.: Nebennierenrindenfunktion und renale Pressormechanismen bei experimenteller Hypertension. „Essentielle Hypertonie“, p. 105. Berlin, Göttingen, Heidelberg: Springer 1960.
Gross, O. Buschor and P. Zeugin: Renin in the kidneys of rats with aminonucleoside nephrosis. Amer. J. Physiol. 199, 1 (1960).
Gross, O., and R. HESS: Histochemical changes in kidneys and in salivary glands of rats with experimental hypertension. Proc. Soc. exp. Biol. (N. Y.) 104, 509 (1960).
Gross, O., and P. Lichtlen: Pressor substances in kidneys of renal hypertensive rats with and without adrenals. Proc. Soc. exp. Biol. (N. Y.) 98, 341 (1958).
Gross, O., and P. Lichtlen: Further evidence for a quantitative difference between aldosterone and cortexone. “Aldosterone”, p. 39. An International Symposium. London: Churchill 1958.
Gross, O., P. Loustalot and R. Meier: Production of experimental hypertension by aldosterone. Acta endocr. (Kbh.) 26, 417 (1957).
Gross, O., P. Loustalot, u. F. SULSER: Bedeutung von Kochsalz für den Cortexon-Hochdruck der Ratte und den Gehalt der Nieren an pressorischen Substanzen. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 229, 381 (1956).
Gross, O., and H. Scam: Aldosterone overdosage in the rabbit. Acta endocr. (Kbh.) 28, 467 (1958).
Gross, O. u. F. Sulser: Der Einfluß der Nebennieren auf die blutdrucksteigernde Wirkung von Renin und auf pressorische Substanzen in den Nieren. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 230, 274 (1957).
Hartroft, P. M., and W. S. Hartroft: Studies on renal juxtaglomerular cells: 1. Variations produced by sodium chloride and desoxycorticosterone acetate. J. exp. Med. 97, 415 (1953).
Hartroft, P. M., and W. S. Hartroft: Studies on renal juxtaglomerular cells: 2. Correlation of degree of granulation of juxtaglomerular cells with width of zona glomerulosa of adrenal cortex. J. exp. Med. 102, 205 (1955).
Hess, R., and F. Gross: Glucose-6-phosphate dehydrogenase and renin in kidneys of hypertensive or adrenalectomized rats. Amer. J. Physiol. 197, 869 (1959).
Kumar, D., W. Anderson and A. G. Gornall: Postmortem study of rats made hypertensive by aldosterone. J. clin. Endocr. 16, 918 (1956).
Laragh, J. H.: Relation of aldosterone secretion to hypertensive vascular disease. Circulat. Res. 9, 792 (1961).
Laragh, J. H.: Interrelationships between angiotensin, norepinephrine, epinephrine, aldosterone secretion, and electrolyte metabolism in man. Circulation 25, 203 (1962).
Laragh, J. H, S. Ulick, V. Januszewicz, Q. B. Deming, W G Kelly and S. Lieberman • Aldosterone secretion and primary and malignant hypertension. J. clin. Invest. 39, 1091 (1960).
Laragh, J. H, M. Angers, W. G. Kelly and S. Lieberman: Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II, and others on the secretory rate of aldosterone in man. J. Amer. med. Ass. 174, 234 (1960).
Mulrow, P. J., W. F. Ganong, G. Cera and A. Kuljian: The nature of the aldosteronestimulating factor in dog kidneys. J. clin. Invest. 41, 505 (1962).
Mulrow, P. J., W. F. Ganong, G. Cera and A. Kuljian: Role of the kidney and the renin-angiotensin system in the response of aldosterone secretion to hemorrhage. Circulation 25, 213 (1962).
Neher, R.: Aldosterone and other adrenocortical hormones in human adrenals and adrenal tumours. “Aldosterone”, p. 11; an International Symposium. London: Churchill 1958.
Omae, T., G. M. C. Masson and I. H. PAGE: Release of pressor substances from renal grafts originating from rats with renal hypertension. Circulat. Res. 9, 441 (1961).
Peart, W. S.: Verh. dtsch. Ges. Kreisl.-Forsch. 1962 (in press).
Pitcock, J. A., P. M. Hartroft and L. N. Newmark: Increased renal pressor activity (Renin) in sodium deficient rats and correlation with juxtaglomerular cell granulation. Proc. Soc. exp. Biol. (N. Y.) 100, 868 (1959).
Regoli, D., H. Brunner, G. Peters and F. Gross: Changes in renin content in kidneys of renal hypertensive rats. Proc. Soc. exp. Biol. (N. Y.) 109, 142 (1962).
Regoli, D., R. Hess, H. Brunner, G. Peters and F. Gross: Interrelationship of renin content in kidneys and blood pressure in renal hypertensive rats. Arch. in Pharmacodyn. 140, 416 (1962).
Ross, E. J.: Aldosterone in clinical and experimental medicine. Springfield: Thomas 1959.
Selye, H., and C. E. Hall: Pathologic changes induced in various species by overdosage with desoxycorticosterone. Arch. Path. 36, 19 (1943).
Selye, H.: Production of nephrosclerosis and cardiac hypertrophy in the rat by desoxycorticosterone acetate overdosage. Amer. Heart J. 27, 338 (1944).
Skelton, F. R.: Adrenal regeneration and adrenal-regeneration hypertension. Physiol. Rev. 39, 162 (1959).
Slater, J. D. H., H. H. Henderson, A. C. T. Casper, B. H. Barton and F. C. Bartter: Control of adrenal cortical activity by the renin-angiotensin system with changes in renal blood flow. Clin. Res. 10, 256 (1962).
Smithwick, R. H., D. Kinsey and G. P. Wfutelaw: Surgical treatment of hypertension — Primary aldosteronism New Engl. J. Med. 266, 160 (1962).
Tobtan, L.: Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol. Rev. 40, 280 (1960).
Tobtan, L.: Relationship of juxtaglomerular apparatus to renin and angiotensin. Circulation 25, 189 (1962).
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Gross, F. (1963). Aldosteron und Hochdruck. In: Nowakowski, H. (eds) Aldosteron. Neuntes Symposion der Deutschen Gesellschaft für Endokrinologie, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85522-1_1
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