Advertisement

Renin-Angiotensin-System und Pathogenese des renalen Hochdruckes

  • F. Gross
Conference paper

Zusammenfassung

Jeder Versuch, im heutigen Zeitpunkt die Bedeutung des Renin/Angiotensin-Systems für die Pathogenese des Hochdruckes zu beurteilen, muß berücksichtigen, daß unsere Kenntnisse noch lückenhaft sind. Dies gilt sowohl für das System selbst und seine Kinetik als auch für die ihm unter physiologischen Bedingungen zukommenden Aufgaben. Insbesondere ist nicht bekannt, wo die Reaktion zwischen Enzym und Substrat stattfindet, ob noch zusätzliche Faktoren — Inhibitoren oder Aktivatoren — daran beteiligt sind und in welcher Form Renin oder Angiotensin im Plasma transportiert wird. Verwirrend ist weiterhin, daß verschiedene Arbeitsgruppen einander anscheinend widersprechende Befunde erhoben haben. Versucht man jedoch, diese Diskrepanzen zu analysieren und ihren Ursachen nachzugehen, so findet sich häufig, daß Resultate miteinander verglichen werden, die unter ganz verschiedenen Bedingungen erhalten wurden. Es ist daher notwendig, zunächst die wichtigsten Unterschiede in den Versuchsanordnungen sowie bei der Bestimmung der Renin/Angiotensin-Aktivität einander gegenüberzustellen und sie bei der Interpretation der Befunde zu berücksichtigen. Es handelt sich in erster Linie um die folgenden

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ames, R.P., Borkowski, A.J., Sicinski, A.M. u. Laragh, J.H.: Prolonged infusions of angiotensin II and norepinephrine on blood pressure, electrolyte balance, and aldosterone and Cortisol secretion in normal man and in cirrhosis with ascites. J. Clin. Invest. 44, 1171 (1965).PubMedCrossRefGoogle Scholar
  2. August, J.T., Nelson, D.H. u. Thorn, G.W.: Response of normal subjects to large amounts of aldosterone. J. Clin. Invest. 37, 1549 (1958).PubMedCrossRefGoogle Scholar
  3. Bing, J.: Renal hypertension in renin depleted rats. Acta path. microbiol. scand. 56, 362 (1962).PubMedCrossRefGoogle Scholar
  4. Bock, K.D. u. Gross, F.: Venendruckänderungen nach Gabe von Renin, Angiotensin und Noradrenalin. Arch. exp. Path. Pharmakol. 242, 188 (1961).CrossRefGoogle Scholar
  5. Brown, J.J., Davies, D.L., Doak, P.B., Lever, A.F. u. Robertson, J.I.S.: Plasma-renin in normal pregnancy. Lancet 1963/II, 900.CrossRefGoogle Scholar
  6. Brown, J.J., Davies, D.L., Lever, A.F. u. Robertson, J.I.S.: Variations in plasma-renin concentration in several physiological and pathological states. Canad. Med. Ass. J. 90, 201 (1964).PubMedGoogle Scholar
  7. Brunner, H.: Persönl. Mitteilung.Google Scholar
  8. Byrom, F.B. u. Dodson, L.F.: Mechanism of vivious circle in chronic hypertension. Clin. Sci. 8, 1, (1949).PubMedGoogle Scholar
  9. Conn, J.W.: Primary aldosteronism. J. Lab. Clin. Med. 45, 661 (1955).PubMedGoogle Scholar
  10. Conn, J.W., Rovner, D.R. u. Cohen, E.L.: Normal and altered function of the renin-angiotensin-aldosterone system in man. Applications in clinical and research medicine. Ann. Int. Med. 63, 266 (1965).PubMedGoogle Scholar
  11. Dahl, L.K. u. Schackow, E.: Effects of chronic excess salt ingestion: experimental hypertension in the rat. Canad. Med. Ass. J. 90, 155 (1964).PubMedGoogle Scholar
  12. Dahl, L.K., Heine, M. u. Tassinari, L.: Effects of chronic excess salt ingestion. Further demonstration that genetic factors influence the development of hypertension: Evidence from experimental hypertension due to adrenal regeneration. J. Exp. Med. 122, 533 (1965).PubMedCrossRefGoogle Scholar
  13. Dustan, H.P. u. Page, I.H.: Some factors in renal and renoprival hypertension. J. Lab. Clin. Med. 64, 948 (1964).PubMedGoogle Scholar
  14. Floyer, M.A.: The effect of nephrectomy and adrenalectomy upon the blood pressure in hypertensive and normotensive rats. Clin. Sci. 10, 405 (1951).PubMedGoogle Scholar
  15. Frieden, J., Stamler, J., Hwang, W., Kuramoto, K. u. Katz, L.N.: Effect of chronic salt depletion on blood pressure of renal hypertensive dogs. Am. J. Physiol. 168, 501 (1952).Google Scholar
  16. Genest, J.: Angiotensin, aldosterone, and human arterial hypertension. Canad. Med. Ass. J. 84, 403 (1961).PubMedGoogle Scholar
  17. Genest, J., Nowaczynski, W., Koiw, E., Sandor, T. u. Biron, P.: Nebennierenrindenfunktion bei essentieller Hypertonie. In “Essentielle Hypertonie”. Berlin etc.: Springer 1960, S. 143.Google Scholar
  18. Genest, J., Boucher, R., de Champlain, J., Veyrat, R., Chretien, M., Biron, P., Tremblay, G. u. Cartier, P.: Studies on the renin-angiotensin system in hypertensive patients. Canad. Med. Ass. J. 90, 263 (1964).PubMedGoogle Scholar
  19. Giebisch, G., Klose, R.M. u. Windhager, E.E.: Micropuncture study of hypertonic sodium chloride loading in the rat Am. J. Physiol. 206, 687 (1964).PubMedGoogle Scholar
  20. Giovannetti, S., Bigalli, A. u. Balestri, P.L.: On the pathogenesis of renoprival hypertension. Experientia 21, 288 (1965).PubMedCrossRefGoogle Scholar
  21. Glabman, S., Aynedjian, H.S. u. Bank, N.; Micropuncture study of the effect of acute reductions in glomerular filtration rate on sodium and water reabsorption by the proximal tubules of the rat.Google Scholar
  22. Grollman, A. u. Harrison, T.R.: Effect of rigid sodium restriction on blood pressure and survival of hypertensive rats. Proc. Soc. Exp. Biol. Med. 60, 52 (1945).PubMedGoogle Scholar
  23. Gross, F.: Nebennierenrindenfunktion und renale Pressor-Mechanismen bei experimenteller Hypertension. In “Essentielle Hypertonie”. Berlin etc.: Springer 1960, S. 105.Google Scholar
  24. Gross, F., Schächtelin, G., Brunner, H. u. Peters, G.: The role of the renin-angiotensin system in blood pressure regulation and kidney function. Canad. Med. Ass. J. 90, 258 (1964).PubMedGoogle Scholar
  25. Gross, F., Brunner, H. u. Ziegler, M.: Renin-angiotensin system, aldosterone, and sodium balance. Rec. Progr. Horm. Res. 21, 119 (1965).PubMedGoogle Scholar
  26. Hartroft, P.M. u. Hartroft, W.S.: Studies on renal juxtaglomerular cells: I. Variations produced by sodium chloride and desoxycorticosterone acetate. J. Exp. Med. 97, 415 (1953).PubMedCrossRefGoogle Scholar
  27. Laragh, J.H., Angers, M., Kelly, W.G. u. Lieberman, S.: Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II, and others on the secretory rate of aldosterone in man. J. Am. Med. Ass. 174, 234 (1960).CrossRefGoogle Scholar
  28. Laragh, J.H., Ulick, S., Januszewicz, V., Deming, Q.B., Kelly, W.G. und Lieberman, S.: Aldosterone secretion and primary and malignant hypertension. J. Clin. Invest. 39, 1091 (1960).PubMedCrossRefGoogle Scholar
  29. Lassiter, W.E., Mylle, M. u. Gottschalk, C.W.: Net transtubular movement of water and urea in saline diuresis. Am. J. Physiol. 206, 669 (1964).PubMedGoogle Scholar
  30. McCubbin, J.W. u. Page, I.H.: Renal pressor system and neurogenic control of arterial pressure. Circulat. Res. 12, 553 (1963).Google Scholar
  31. Olmsted, F. u. Page, I.H.: Hemodynamic aspects of prolonged infusion of angiotensin into unanesthetized dogs. Circulat. Res. 16, 140 (1965).PubMedGoogle Scholar
  32. Peart, W.S.: Mögliche Beziehungen zwischen Salzstoffwechsel und dem Angiotensin-System. In “Essentielle Hypertonie”. Berlin etc.: Springer 1960, S. 127.Google Scholar
  33. Peart, W.S.: The functions for renin and angiotensin. Rec. Progr. Horm. Res. 21, 73 (1965a).PubMedGoogle Scholar
  34. Peart, W.S.: The renin-angiotensin system. Pharmacol. Rev. 17, 143 (1965 b).PubMedGoogle Scholar
  35. Peart, W.S. u. Brown, J.J.: Effect of angiotensin on urine flow and electrolyte excretion in hypertensive patients. Lancet 1961/I, 28.CrossRefGoogle Scholar
  36. Pickering, G.W.: The role of the kidney in acute and chronic hypertension following renal artery constriction in the rabbit. Clin. Sci. 5, 229 (1945).PubMedGoogle Scholar
  37. Regoli, D., Hess, R., Brunner, H., Peters, G. u. Gross, F.: Interrelationship of renin content in kidneys and blood pressure in renal hypertensive rats. Arch. int. pharmacodyn. 140, 416 (1962).PubMedGoogle Scholar
  38. Schächtelin, G., Regoli, D. u. Gross, F.: Bioassay of circulating renin by isovolemic cross circulation. Am. J. Physiol. 205, 303 (1963).Google Scholar
  39. Singer, B., Losito, C. u. Salmon, S.: Aldosterone and corticosterone secretion rates in rats with experimental hypertension.Google Scholar
  40. Sokabe, H.: Renin-angiotensin system in the spontaneously hypertensive rat. Nature 205, 90 (1965).PubMedCrossRefGoogle Scholar
  41. Stamey, T.A.: Some observations on the filtration fraction, on the transport of sodium and water in the ischemic kidney, and on the prognostic importance of RPF to the contralateral kidney in renovascular hypertension. In “Antihypertensive therapy”. Berlin etc.: Springer, im Druck.Google Scholar
  42. Venning, E.H., Dyrenpurth, I., Dossetor, J.B. u. Beck, J.C.: Essential hypertension and aldosterone. Circulation 23, 168 (1961).PubMedGoogle Scholar
  43. Verniory, A. u. Potvliege, P.: Effects of cortexone and salt on renin content, juxtaglomerular index and renal hypertension in rabbits. Proc. Soc. Exp. Biol. Med. 115, 18 (1964).PubMedGoogle Scholar
  44. Wilson, C. u. Byrom, F.B.: Vicious circle in chronic Bright’s disease. Experimental evidence from hypertensive rat. Quart. J. Med. 10, 65 (1941).Google Scholar

Copyright information

© Springer-Verlag Berlin • Heidelberg 1966

Authors and Affiliations

  • F. Gross

There are no affiliations available

Personalised recommendations