Adalat pp 167-168 | Cite as

Arterial Calcium Overload: A Cardinal Element in the Development of Arteriosclerosis and Vasoprotection with Calcium Antagonists

  • A. Fleckenstein
  • M. Frey
  • F. Thimm
  • G. Fleckenstein-Grün
Conference paper

Abstract

At present, the antiarteriosclerotic efficacy of calcium (Ca) antagonists, first described in 1971 [1] and subsequently analyzed in a multitude of experimental models on rats by Fleckenstein and coworkers [2–6], is increasingly gaining interest. It is a well-known fact that in arterial walls that are altered by sclerotic processes, two main constituents accumulate: lipids (particularly cholesterol) and Ca. However, the accumulation of lipids has long been incriminated as the primordial pathogenic factor, whereas the concomitant arterial Ca overload was considered a phenomenon of secondary importance. This is rather puzzling, because in 1913, the same year as Anitschkow [7] first produced atheromatous lesions in cholesterol-fed rabbits, Katase [8] depicted calcific incrustation and subsequent destruction of the internal elastic membrane in the arterial walls of guinea pigs and rabbits injected with soluble calcium salts. But Anitschkow’s cholesterol-fed rabbits overshadowed Katase’s observations completely.

Keywords

Cholesterol Nicotine Nifedipine Dial Choles 

References

  1. 1.
    Janke J, Hein B, Pachinger O, Leder O, Fleckenstein A (1972) Hemmung arteriosklerotischer Gefäßprozesse durch prophylaktische Behandlung mit MgCl2, KCl und organischen Ca++-Antagonisten (quantitative Studien mit Ca45 bei Ratten). In: Betz E (ed) Vascular smooth muscle. Verh Satellit Symp XXV Internat Congr f Physiol Wissensch Tübingen, Juli 1971, Springer, Berlin Heidelberg New York, pp 71–72CrossRefGoogle Scholar
  2. 2.
    Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G (1985) Experimental basis of the long-term therapy of arterial hypertension with calcium antagonists. Am J Cardiol 56:3H-14HPubMedCrossRefGoogle Scholar
  3. 3.
    Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G (1985) Interdependence of antihypertensive, anticalcinotic and antiarteriosclerotic effects of calcium antagonists — model experiments on spontaneously hypertensive rats. In: Fleckenstein A, van Breemen C, Groß R, Hoffmeister F (eds) Cardiovascular effects of dihydropyridine-type calcium antagonists and agonists. Bayer-Symposium IX, Springer, Berlin Heidelberg New York, Tokyo pp 480–499CrossRefGoogle Scholar
  4. 4.
    Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G (1987) The role of calcium in the pathogenesis of experimental arteriosclerosis. Trends Pharmacol Sei 8:496–501CrossRefGoogle Scholar
  5. 5.
    Fleckenstein A, Fleckenstein-Grün G, Frey M, Zorn J (1989) Calcium antagonism and ACE-inhibition. Two outstandingly effective means of interference with cardiovascular calcium overload, high blood pressure, and arteriosclerosis in spontaneously hypertensive rats. Am J Hyperts 2:194–204Google Scholar
  6. 6.
    Fleckenstein A, Frey M, Zorn J, Fleckenstein-Grün G (1990) Calcium, a neglected key factor in hypertension and arteriosclerosis. Experimental vasoprotection with calcium antagonists or ACE inhibitors. In: Laragh JH, Brenner BM (eds) Hypertension: pathophysiology, diagnosis, and management. Raven, New York, pp 471–509Google Scholar
  7. 7.
    Anitschkow N, Chałatów S (1913) Über experimentelle Cholesterinsteatose und ihre Bedeutung für die Entstehung einiger pathologischer Prozesse. Zentralbl Allg Pathol Anat 14:1–9Google Scholar
  8. 8.
    Katase A (1913) Experimentelle Verkalkung am gesunden Tiere. Beitr Pathol Anat Allg Pathol 57:516–550Google Scholar
  9. 9.
    Fleckenstein A, Frey M, Thimm F, Fleckenstein-Grün G (1990) Excessive mural calcium overload — a predominant causal factor in the development of stenosing coronary plaques in humans. Cardiovasc Drugs Ther 4:1005–1014PubMedCrossRefGoogle Scholar
  10. 10.
    Fleckenstein A, Fleckenstein-Grün G (1980) Cardiovascular protection by Ca antagonists. Eur Heart J 1:15–21PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. Fleckenstein
    • 1
  • M. Frey
    • 1
  • F. Thimm
    • 1
  • G. Fleckenstein-Grün
    • 1
  1. 1.Study Group for Calcium Antagonism Physiological InstituteUniversity of FreiburgFreiburgGermany

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