Abstract
Starting from the observations that both egg-white sensitized and normal mouse uteri are 1000 times more sensitive to 5-HT than they are to histamine and that LSD and reserpine always completely prevent anaphylactic contraction on strips of sensitized uteri, Fink (1956) first suggested that the Schultz-Dale reaction and, more generally, the systemic anaphylactic reaction in the mouse was dependent on the release of 5-HT.
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Erspamer, V. (1966). Participation of 5-hydroxytryptamine in physiopathological processes. In: Erspamer, V. (eds) 5-Hydroxytryptamine and Related Indolealkylamines. Handbook of Experimental Pharmacology/Handbuch der experimentellen Pharmakologie, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85467-5_8
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