Morphological changes caused by injections of 5-HT in animals and man

  • R. S. Stacey
Part of the Handbook of Experimental Pharmacology/Handbuch der experimentellen Pharmakologie book series (HEP, volume 19)


The rapid inactivation of 5-HT makes it possible to give large doses to animals over many weeks ; moreover tolerance rapidly develops and near lethal doses can be quickly increased. Hedinger and Veraguth (1962) for example, using rats, started with daily intraperitoneal doses of 1 to 15 mg base/kg and were able to increase the dose to over 500 mg base/kg in 20 days. Similarly with guinea-pigs, starting with a dose of 40 mg base/kg i.p., the dose could be doubled every 5 days until 320 mg base/kg was being given. However when large doses are given, whether singly or repeatedly, morphological changes develop in many organs.


Gastric Secretion Lysergic Acid Sodium Glutamate Lysergic Acid Diethylamide Serotonin Precursor 
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© Springer-Verlag, Berlin · Heidelberg 1966

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