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Morphological changes caused by injections of 5-HT in animals and man

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5-Hydroxytryptamine and Related Indolealkylamines

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Abstract

The rapid inactivation of 5-HT makes it possible to give large doses to animals over many weeks ; moreover tolerance rapidly develops and near lethal doses can be quickly increased. Hedinger and Veraguth (1962) for example, using rats, started with daily intraperitoneal doses of 1 to 15 mg base/kg and were able to increase the dose to over 500 mg base/kg in 20 days. Similarly with guinea-pigs, starting with a dose of 40 mg base/kg i.p., the dose could be doubled every 5 days until 320 mg base/kg was being given. However when large doses are given, whether singly or repeatedly, morphological changes develop in many organs.

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  1. R. S. Stacey
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Vittorio Erspamer

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Stacey, R.S. (1966). Morphological changes caused by injections of 5-HT in animals and man. In: Erspamer, V. (eds) 5-Hydroxytryptamine and Related Indolealkylamines. Handbook of Experimental Pharmacology/Handbuch der experimentellen Pharmakologie, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85467-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-85467-5_13

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