Diabetes durch kontrainsuläre Hormone
Part of the Verhandlungen der Deutschen Gesellschaft für Innere Medizin book series (VDGINNERE, volume 93)
This review will mention possible involvements of all the hormones which oppose insulin action: glucagon, catecholamines, ACTH-cortisol, and growth hormone (GH). A general hypothesis, already presented some 20 years ago by the author, will be discussed: that only subjects with a genetically diminished capacity to release insulin in relation to insulin sensitivity develop diabetes under the influence of hormones opposing insulin action. The presentation will concentrate on the action of GH as a “diabetogenic” hormone:
A review will also be presented on the mechanism of action of GH in relation to its diabetogenic action: the mechanism of insulin resistence as revealed on isolated tissues (glucose uptake, transport and phosphorylation: free fatty acid metabolism; number of insulin receptors and their affinity).
by its effect in hypophysectomized subjects with IDDM;
by the effect of hypophysectomy in acromegalic patients with and without diabetes;
as presented in animal experiments.
© J. F. Bergmann Verlag, München 1987