Neue experimentelle Aspekte zur Pathogenese der Arteriosklerose bei Familiärer Hypercholesterinämie

  • H. A. Dresel
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für Innere Medizin book series (VDGINNERE, volume 92)

Zusammenfassung

Wir haben bei drei Patienten mit schwerer homozygoter Familiärer Hypercholesterinämie (FH) eine deutliche Monozytose gefunden. Das Zytoplasma einer Subpopulation der Leukozyten dieser Patienten streute intensiver Licht nach Exposition des Zellen gegenüber Ölrot, einem spezifischen Lipidfarbstoff. Die Leukozyten der FH-Patienten hatten eine erhöhte Bindungskapazität für acetyliertes Low Density Lipoprotein (LDL), wahrscheinlich als Konsequenz der Monozytose bei unseren FH-Patienten. Möglicherweise steht die bei exzessiver Hypercholesterinämie beobachtete Monozytose im Zusammenhang mit einer zellulären Reaktion, die auch bei der Ausbildung der arteriosklerotischen Frühläsion von Bedeutung ist.

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Copyright information

© J. F. Bergmann Verlag, München 1986

Authors and Affiliations

  • H. A. Dresel
    • 1
  1. 1.Medizinische KlinikUniversität HeidelbergDeutschland

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