Zusammenfassung
Katecholamine spielen für die Mobilisation von Depotfett im Organismus eine wichtige Rolle. Im Gegensatz zu anderen Spezies vermag diese Hormonklasse beim Menschen die Freisetzung von Glyzerin und Fettsäuren aus dem Fettgewebe nicht nur zu stimulieren, sondern auch zu hemmen (Kather 1981). Die aktivierenden Wirkungen von Adrenalin und Noradrenalin werden über Beta-Rezeptoren vermittelt, die Hemmung der Depotfettmobilisation erfolgt über Alpha2-Rezeptoren.
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Literatur
Arner P, Engefeldt P, Nowak J (1981) In vivo observations on the lipolytic effect of noradrenaline during therapeutic fasting. J Clin Endocrinol Metab 53: 1207–1212
Hales CN, Lucio JP, Siddle K (1978) Hormonal control of adipose tissue lipolysis. Biochem Soc Symp 43: 97–135
Kather H (1981) Hormonal regulation of adipose tissue lipolysis in man: Implications for the pathogenesis of obesity. Triangle 20: 131–143
Kather H, Schröder F, Simon B (1982) Microdetermination of glycerol using bacterial NADH-linked luciferase. Clin Chim Acta 120: 295–300
Kjellberg J, Östman J (1971) Lipolysis and glucose tolerance in obese subjects during prolonged starvation. Acta Med Scand 190: 191–198
Rodbell M ( 1964 ) Metabolism of isolated fat cells. J Biol Chem 239–384
Vasselli JR et al. (1983) Modern concepts of obesity. Nutr Rev 41: 361–373
Green H, Kehinde O (1975) An established preadipose cell-line and its differentiation in culture. II. Factors influencing the adipose conversion. Cell 5: 19–27
Kuri-Harcuch W, Green H (1978) Adipose conversion of 3T3 cells depends on a serum factor. Proc Natl Acad Sci USA 75: 6107–6109
Grimaldi P et al. (1982) Differentiation of ob 17 preadipocytes to adipocytes: requirement of adipose conversion factor(s) for fat cell cluster formation. EMBO J 1: 687–693
Löffler G et al. (1983) An adipogenic serum factor in genetically obese rodents. FEBS Lett 153: 179–182
Morikawa M et al. (1982) Growth hormone and the adipose conversion of 3T3 cells. Cell 29: 783–789
Häussinger D (1983) Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur J Biochem 133: 269–275
Häussinger D, Gerok W (1984) Hepatocyte heterogeneity in ammonia metabolism: impairment of glutamine synthesis in CCI4 induced liver cell necrosis with no effect on urea synthesis. Chem Biol Interact 48: 191–194
Häussinger D, Sies H (1979) Hepatic glutamine metabolism under the influence of the portal ammonia concentration in the perfused rat liver. Eur J Biochem 101: 179–184
Häussinger D, Gerok W, Sies H (1983) Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver. Biochim Biophys Acta 755: 272–278
Häussinger D, Sies H (1984) Effect of phenylephrine on glutamate and glutamine metabolism in isolated perfused rat liver. Biochem J (in press)
Atkinson DE, Camien MN (1982) The role of urea synthesis in the removal of metabolic bicarbonate and the regulation of blood pH. Curr Top Cell Regu121: 261–302
Oliver J, Koelz AM, Costello J, Bourke E (1977) Acid-base induced alterations in glutamine metabolism and ureogenesis in perfused muscle and liver of the rat. Eur J Clin Invest 7: 445–449
Häussinger D, Gerok W, Sies H (1984) Hepatic role in pH regulation. Role of the intercellular glutamine cycle. Trends Biochem Sci (in press)
Häussinger D, Akerboom TPM, Sies H (1980) The role of pH and the lack of a requirement for hydrogencarbonate in the regulation of hepatic glutamine metabolism. Hoppe Seylers Z Physiol Chem 361: 995–1001
Orrego H, Carmichael FJ, Phillips MJ, Kalant H, Khanna J, Israel Y (1976) Gastroenterology 71: 821–826
Schanne FAX, Pfau RG, Farber JL (1980) Am J Pathol 100: 25–38
Reichlin S (1983) N Engl J Med 309: 1556–1563
Limberg B, Kommerell B (1983) IRCS Med Sci 11: 572–573
Adler RD, Bennion LH, Duane WS et al. (1975) Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism. Gastroenterology 68: 326–334
Admirand WH, Small DM (1968) The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest 47: 1043–1052
Angelin B, Einarsson K, Leijd B (1979) Biliary lipid composition during treatment with different hypolipidaemic drugs. Eur J Clin Invest 9: 185–190
Angelin B, Einarsson K, Leijd B (1984) Effect of ciprofibrate treatment on biliary lipids in patients with hyperlipoproteinaemia. Eur J Clin Invest 14: 73–78
Bateson MC, Maclean D, Ross PE et al. (1978) Clofibrate therapy and gallstone induction. Dig Dis 23: 623–628
Bartlett GR (1959) Phosphorous assay in column chromatography. J Biol Chem 234: 466–468
Carey M, Small DM (1978) The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest 61: 998–1026
Creger PL, Moersch GW, Neuklis WA (1976) Structure activity relationship of gemfibrozil (CI-719) and related compounds. Proc R Soc Med (Suppl 2 ) 69: 3–5
Eggstein M, Kreutz FH (1966) Eine neue Bestimmung der Neutralfette in Blutserum and Gewebe. Klin Wochenschr 44: 262–266
Grundy SM, Ahrens EH Jr, Salen G et al. (1972) Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia. J Lipid Res 13: 531–551
Grundy SM, Metzger AL (1972) A physiological method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 62: 1200–1217
Hall MJ, Nelson LM, Russel RI et al. (1981) Gemfibrozil–the effect on biliary cholesterol saturation of a new lipid-lowering agent and its comparison with clofibrate. Atherosclerosis 39: 511–516
Hjermann I, Velve Byre K, Holme I, Leren P (1981) Effect of diet and smoking intervention on the incidence of coronary heart disease. Lancet 2: 1303–1313
Hofmann AF, Grundy SM, Lachin JM et al. (1982) Pretreatment biliary lipid composition in white patients with radiolucent gallstones in the National Cooperative Gallstone Study. Gastroenterology 83: 738–752
Kaukola S, Manninen V, Malkonen M et al. (1981) Gemfibrozil in the treatment of dyslipidaemias in middle-aged male survivors of myocardial infarction. Acta Med Scand 209: 69–73
Kesaniemi YA, Grundy SM (1984) Influence of gemfibrozil on metabolism of cholesterol and plasma triglycerides in man. JAMA (in press)
Kissebah AH, Adams PA, Wynn V (1976) Lipokinetic studies with gemfibrozil (CI-719). Proc R Soc Med (Suppl 2 ) 69: 94–97
Lageder H, Irsigler K (1976) Evalution of increasing doses of gemfibrozil in hyperlipoproteinaemia. Proc R Soc Med (Suppl 2 ) 69: 71–75
LaRusso NF, Hoffman NE, Hofmann AF et al. (1975) Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients. Gastroenterology 69: 1301–1314
Leiß O, von Bergmann K (1983) Zusammenhänge zwischen Serum-Lipoproteinstoffwechsel and biliärem Lipidstoffwechsel. Klin Wochenschr 61: 579–592
Leiß O, von Bergmann K (1984) Einfluß von Fenofibrat and Bezafibrat auf den biliären Lipidstoffwechsel. In: Kaffarnik H, Schneider J (Hrsg) Hyperlipoproteinämie. Pathophysiologie–Diagnostik–Therapie. perimed Fachbuch-Verlagsgesellschaft mbH, Erlangen, S 168–174
Lipid Research Clinics Program (1984) The lipid research clinics coronary primary prevention trial results. I. Reduction in incidence of coronary heart disease. JAMA 251: 351–364
Lipid Research Clinics Program (1984) The lipid research clinics coronary primary prevention trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 365–374
Lipid Research Clinics Program Manual of Laboratory Operations (1974) Department of Health, Education of Welfare Publication. NIH 75–628
Miettinen TA, Ahrens EH, Grundy SM (1965) Quantitative isolation and gas-liquid chromatographic analysis of total dietary and fecal neutral steroids. J Lipid Res 6: 411–424
Nair PP, Gordon M, Reback J (1967) The enzymic cleavage of the carbon-nitrogen bound in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-25-oylglycine. J Biol Chem 242: 7–11
Nash DT (1980) Gemfibrozil–a new lipid lowering agent. J Med 11: 107–116
Nikkila EA, Ylikahri R, Huttunen JK (1976) Gemfibrozil: effect on serum lipids, lipoproteins, postheparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia. Proc R Soc Med (Suppl 2 ) 69: 58–63
O’Connor RE (1982) Gemfibrozil–Results of clinical studies in the United States. In: Ricci G, Paoletti R, Pocchiari F, Poggiolini D (eds) Therapeutic selectivity and risk/benefit assessment of hypolipidemic drugs. Raven Press, New York, pp 59–61
Olsson AG, Roessner S, Wallding G et al. (1976) Effect of gemfibrozil on lipoprotein concentrations in different types of hyperlipoproteinaemia. Proc R Soc Med (Suppl 2 ) 69: 28–31
Palmer RH (1978) Prevalence of gallstones in hyperlipidemia and incidence during treatment with clofibrate and/or cholestyramine. Trans Assoc Am Physicians 91: 424–432
Paumgartner G, Horak W, Probst P et al. (1971) Effect of phenobarbital on bile flow and bile salt excretion in the rat. Naunyn-Schmiedebergs Arch Pharmako1270: 98–102
Pertsemlidis D, Panveliwalla D, Ahrens EH Jr (1974) Effects of clofibrate and of an estrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man. Gastroenterology 66: 565–573
Report from the Committee of Principal Investigators (1978) A co-operative trial in the primary prevention of ischemic heart disease using clofibrate. Br Heart J 40: 1069–1118
Roeschlau P, Bernt E, Gruber W (1974) Enzymatische Bestimmung des Gesamt-Cholesterins im Serum. Z Klin Chem Klin Biochem 12: 226–231
Schlierf G, Chwat M, Feuerborn E et al. (1980) Biliary and plasma lipids and lipid-lowering chemotherapy–studies with clofibrate, fenofibrate and etofibrate in healthy volunteers. Atherosclerosis 36: 323–329
Schlierf G, Fischer H, Roche A et al. (1980) Gallenlipide unter Bezafibrat. Münch Med Wochenschr 122: 165–168
Schwandt P, Weisweiler P, Neureuther G (1979) Serum lipoprotein lipids after gemfibrozil treatment. Artery 5: 117–124
Sedaghat A, Grundy SM (1980) Cholesterol crystals and the formation of cholesterol gallstones. N Engl J Med 302: 1274–1277
Sedaghat A, Kesaniemi YA, Grundy SM (1983) Cholesterol crystals — a crucial link in formation of cholesterol gallstones. In: Paumgartner G, Stiehl A, Gerok W (eds) Bile acids and cholesterol in health and diseases. MTP Press, Lancaster, pp 43–53
Talalay P (1960) Enzymatic analysis of steroid hormones. Methods Biochem Anal 8: 114–143
The Coronary Drug Project Research Group (1975) Coronary drug project. Clofibrate and niacin in coronary heart disease. JAMA 231: 360–381
Van Berge Henegouwen GP, Allan RN, Hofmann AF et al. (1977) A facile hydrolysis-solvolysis procedure for conjugated bile acid sulfates. J Lipid Res 18: 118–122
Vessby B, Lithell H, Boberg J et al. (1976) Gemfibrozil as a lipid lowering compound in hyperlipoproteinaemia. A placebo-controlled cross-over trial. Proc R Soc Med (Supp12) 69: 30–37
von Bergmann K, Leiss O (1984) Effect of short-term treatment with bezafibrate and fenofibrate on biliary lipid metabolism in patients with hyperlipidemia. Eur J Clin Invest 14: 150–154
von Bergmann K, Leiß O (1984) Unveröffentlichte Ergebnisse
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Kather, H. et al. (1984). Stoffwechsel II. In: 90. Kongreß. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 90. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85457-6_58
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DOI: https://doi.org/10.1007/978-3-642-85457-6_58
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