90. Kongreß pp 636-655 | Cite as

Hämostaseologie

  • W. Klaubert
  • C.-H. Bushe
  • R. Hafter
  • R. Gollwitzer
  • W. Wilmanns
  • H. Graeff
  • T. H. Schöndorf
  • L. Witt
  • H. Pralle
  • A. Jobke
  • D. Heinrich
  • T. Scharf
  • S. Santoso
  • C. Mueller-Eckhardt
  • C. M. Kirchmaier
  • I. Arnold
  • D. Rosenthal
  • R. Brickl
  • H. K. Breddin
  • B.-J. Rasch
  • M. Camerer
  • R. H. Bödeker
  • N. Bender
  • W. Schneider
  • D. Staufenbiel
  • W. D. Bussmann
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für Innere Medizin book series (VDGINNERE, volume 90)

Zusammenfassung

Veränderungen der Gerinnung werden im Schock beobachtet [1, 2]. Die extremste Schockform ist die Reanimationssituation. Wir haben bei sieben Patienten mit kardialem Herzkreislauf- und Atemstillstand, die auf der internistischen Intensivstation unserer Klinik reanimiert wurden, die Koagulations- und Fibrinolyseparameter im Verlauf von vier erfolgreichen und drei erfolglosen Reanimationen bestimmt.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Matthias FR et al. (1982) Hämostaseologie 2: 26Google Scholar
  2. 2.
    Mittermayer Ch et al. (1978) Verh Dtsch Ges Pathol 62: 11PubMedGoogle Scholar
  3. 3.
    Gollwitzer R (1979) Thromb Res 11: 859CrossRefGoogle Scholar
  4. 1.
    Bertina RM, Broekmans AW, van der Linden IK, Mertens K (1982) Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemostas 48: 1–5Google Scholar
  5. 2.
    Bettigole RE, Himelstein ES, Oettgen HF, Clifford GO (1970) Hypofibrinogenemia due to L-asparaginase: studies of fibrinogen survival using autologous 131I-fibrinogen. Blood 35: 195–200PubMedGoogle Scholar
  6. 3.
    Conard J, Cazenave B, Maury J, Horellou MH, Samama M (1980) L-Asparaginase, antithrombin II, and thrombosis. Lancet 1: 1091PubMedCrossRefGoogle Scholar
  7. 4.
    Gralnick HR, Henderson E (1971) Hypofibrinogenemia and coagulation factor deficiencies with L-asparaginase treatment. Cancer 27: 1313–1320PubMedCrossRefGoogle Scholar
  8. 5.
    Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (1981) Deficiency of protein C in congenital thrombotic disease. J Clin Invest 68: 1370–1373PubMedCrossRefGoogle Scholar
  9. 6.
    Kisiel W (1979) Human Protein C. Isolation, characterization and mechanism of activation by a-thrombin. J Clin Invest 64: 761–769PubMedCrossRefGoogle Scholar
  10. 7.
    Liebman HA, Wada JK, Patch MJ, McGehee W (1982) Depression of functional and antigenic plasma antithrombin III ( AT-III) due to therapy with L-asparaginase. Cancer 50: 451–456Google Scholar
  11. 8.
    Pitney WR, Phadke KP, Dean S (1980) Antithrombin III deficiency during asparaginase therapy. Lancet 1: 493–494PubMedCrossRefGoogle Scholar
  12. 9.
    Priest J, Edson JR, Levitt C, Tubergen D, Steinherz P, Cairo M, Bishop A, Sitarz A, White L, Coccia P, Krivit W (1981) Thrombotic complications during L-asparaginase (L-asp)-induced deficiencies of antithrombin (AT), plasminogen (PLAS), and fibrinogen (FIB) in childhood leukemia. ASCO Abstracts, C-612Google Scholar
  13. 10.
    Priest JR, Ramsay NKC, Bennett AJ, Krivit W, Edson JR (1982) The effect of L-asparaginase on antithrombin, plasminogen, and plasma coagulation during therapy for acute lymphoblastic leukemia. J Pediatr 100: 990–995PubMedCrossRefGoogle Scholar
  14. 11.
    Schöndorf TH, Pralle H, Graubner M, Lasch HG (1983) Antithrombin III-deficiency and thromboembolic complications under L-asparaginase treatment. Thromb Haemostas 50: 50Google Scholar
  15. 12.
    Vellenga E, Mulder NH, Nieweg HO (1980) Antithrombin III deficiency during asparaginase therapy. Lancet 1: 649–650PubMedCrossRefGoogle Scholar
  16. 1.
    Nurden AT, Caen JP (1974) An abnormal platelet glycoprotein pattern in three cases of Glanzmann’s thrombasthenia. Br J Haematol 28: 253PubMedCrossRefGoogle Scholar
  17. 2.
    Phillips DR, Jenkins CSP, Löscher EF, Larrieu MJ (1975) Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes. Nature 257: 599PubMedCrossRefGoogle Scholar
  18. 3.
    Phillips DR, Agin PP (1977) Platelet membrane defects in Glanzmann’s thrombasthenia. Evidence for decreased amounts of two major glycoproteins. J Clin Invest 60: 935Google Scholar
  19. 4.
    White GC, Workman EF Jr, Lundblad RL (1978) Thrombin binding to thrombastenic platelets. J Lab Clin Med 91: 76PubMedGoogle Scholar
  20. 5.
    Legrand C, Caen JP (1976) Binding of 14C-ADP by thrombastenic platelet membranes. Haemostasis 5: 231PubMedGoogle Scholar
  21. 6.
    Mustard JF, Kinlough-Rathbone RL, Packham MA, Perry DW, Harfenist EJ, Pai KRM (1979) Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin. Blood 54: 987PubMedGoogle Scholar
  22. 7.
    Bennett JS, Vilaire G (1979) Exposure of platelet fibrinogen receptors by ADP and epinephrine. J Clin Invest 64: 1393PubMedCrossRefGoogle Scholar
  23. 8.
    Cross MJ (1964) Effect of fibrinogen on the aggregation of platelet by adenosine diphosphate. Thromb Haemostas 12: 524Google Scholar
  24. 9.
    McLean JR, Maxwell RE, Hertler D (1964) Fibrinogen and adenosine diphosphate-induced aggregation of platelets. Nature 202: 605PubMedCrossRefGoogle Scholar
  25. 10.
    Polley MJ, Leung LVK, Clark FY, Nachman RL (1981) Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study. J Exp Med 154: 1058Google Scholar
  26. 11.
    Greenberg JP, Packham MA, Guccione MA, Harfenist EJ, Ork JL, Kinglough-Rathbone RL, Perry DW, Mustard JF (1979) The effect of pretreatment of human or rabbit platelets with chymotrypsin on their response to human fibrinogen and aggregating agents. Blood 54: 753PubMedGoogle Scholar
  27. 12.
    Brinkhous KM, Read MS, Mason RG (1965) Plasma thrombocyte agglutinating activity of fibrinogen. Synergism with adenosine diphosphate. Lab Invest 14: 335Google Scholar
  28. 13.
    Degos L, Dautigny A, Brouet JC, Colombani M, Ardaillou N, Caen JP, Colombani J (1975) A molecular defect in thrombasthenic platelets. J Clin Invest 56: 236PubMedCrossRefGoogle Scholar
  29. 14.
    Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495PubMedCrossRefGoogle Scholar
  30. 15.
    Santoso S, Lohmeyer J, Rennich H, Clemetson KJ, Mueller-Eckhardt C (1984) Platelet surface antigens: Analysis by monoclonal antibodies. Blut 48: 161Google Scholar
  31. 16.
    Santoso S: Persönliche MitteilungGoogle Scholar
  32. 17.
    Heinrich D, Gutschank S, Mueller-Eckhardt C (1977) HLA-antibody-induced 14C-serotonin release from platelets. Vox Sang 33: 65PubMedCrossRefGoogle Scholar
  33. 18.
    Kunicki TJ, Aster RH (1978) Deletion of the platelet-specific alloantigen P1A1 from platelets in Glanzmann’s thrombasthenia. J Clin Invest 61: 1225PubMedCrossRefGoogle Scholar
  34. 19.
    Kunicki TJ, Aster RH (1979) Isolation and immunologic characterization of human platelet alloantigen P1A1. Mol Immunol 16: 353PubMedCrossRefGoogle Scholar
  35. 20.
    Pfueller SL, Weber S, Löscher EF (1977) Studies on the mechanism of human platelets release reaction induced by immunologic stimuli. III. Relationship between the binding of soluble IgG aggregates to the Fc receptor and cell response in the presence and absence of plasma. J Immunol 118: 514Google Scholar
  36. Bamberg E, Bauer O, Herrmann W, Kroemer H, Lippmann M, Müller CH, Stegmann H, Breddin KH (1978) Primärer Formwandel der Thrombozyten in vitro. Blut 37: 327–339PubMedCrossRefGoogle Scholar
  37. Bender N, Kirchmaier CM, Bartsch B, Lindenborn D, Breddin KH (1979) Stimulation of blood platelets by extracts of subcutaneous tissue. Thromb Res 14: 341–351PubMedCrossRefGoogle Scholar
  38. Kirchmaier CM, Bender N, Wilhelm B, Al Sayegh A, Breddin KH (1979) A hemostasis activating factor (HAF) in subcutaneous tissue extracts: Effects on morphologic platelet changes, platelet retention and platelet agregation. Thromb Res 16: 81–91Google Scholar
  39. Kirchmaier CM, Bender N, Al Sayegh A, Breddin KH (1980) A platelet stimulating fraction in human and animal tissues. Artery 8: 416–421PubMedGoogle Scholar
  40. Schepping M, Jäger H, Herbst MA, Rosenthal HD, Breddin KH (1982) Änderung der Volumenverteilung der Thrombozyten unter dem Einfluß von Gewebeextrakten und von thrombozytenfunktionshemmenden Medikamenten. In: van de Loo, I., Asbeck, F. (Hrsg) Haemostase, Thrombophilie und Atherosklerose. 2. Kongreß für Thrombose und Hämostase, Münster 1982. F. K. Schattauer, Stuttgart, S. 468–471Google Scholar
  41. Weichert W, Pauliks V, Breddin HK (1983) Laser induced thrombi in rat mesenteric vessels and antithrombotic drugs. Haemostasis 13: 61–71PubMedGoogle Scholar
  42. 1.
    Rosenthal N, Vogel P (1937) Value of sternal puncture on the diagnosis of multiple myeloma. Mt Sinai J Med NY 4: 1001Google Scholar
  43. 2.
    Bernard J, Inceman S, Zara M, Christel D (1952) La dysglobulinémie maligne hémorragipare. Rev Hématol 7: 264PubMedGoogle Scholar
  44. 3.
    Pachter MR, Johnson SA, Neblett TR, Truant JP (1959) Bleeding, platelets and macroglobulinemia. Am J Clin Pathol 31: 467PubMedGoogle Scholar
  45. 4.
    Hurley R, Shaw S (1963) Observations on the haemorrhagic diathesis in multiple myeloma. Postgrad Med J 39: 480PubMedCrossRefGoogle Scholar
  46. 5.
    Viala JJ, Thouverez JP, Belleville J, Revol L, Croizat P (1963) Etude de la coagulation du sang au cours des dysglobulinémies myélomes et maladie de Waldenström à propos de 48 observations. Hémostase 3: 303PubMedGoogle Scholar
  47. 6.
    Rozenberg MC, Dintenfass L (1965) Platelet aggregation in Waldenström’s macroglobulinaemia. Thromb Haemostas 14: 202Google Scholar
  48. 7.
    Smith E, Kochwa S, Wasserman LR (1965) Aggregation of IgG Globulin in vivo. I. The hyperviscosity syndrome in multiple myeloma. Am J Med 39: 35Google Scholar
  49. 8.
    Doumenc J, Prost RJ, Samama M, Bousser J (1966) Anomalie de l’aggrégation plaquettaire au cours de la maladie de Waldenström (à propos de 3 cas). Nouv Rev Fr Hematol Blood Cells 6: 734Google Scholar
  50. 9.
    Kopp WL, Beirne GJ, Burns RO (1967) Hyperviscosity syndrome in multiple myeloma. Am J Med 43: 141PubMedCrossRefGoogle Scholar
  51. 10.
    Vigliano EW, Horowitz HI (1967) Bleeding syndrome in a patient with IgA myeloma: Interaction of protein and connective tissue. Blood 29: 823Google Scholar
  52. 11.
    Cohen I, Amir J, Ben-Shaul Y, Pick A, De Vries A (1970) Plasma cell myeloma associated with an unusual myeloma protein causing impairment of fibrin aggregation and platelet function in a patient with multiple malignancy. Am J Med 48: 766PubMedCrossRefGoogle Scholar
  53. 12.
    Perkins HA, McKenzie MR, Fudenberg HH (1970) Hemostatic defects in dysproteinaemias. Blood 35: 695PubMedGoogle Scholar
  54. 13.
    Benninger GW, Kreps SI (1971) Aggregation phenomenon in an IgG multiple myeloma resulting in the hyperviscosity syndrome. Am J Med 51: 287PubMedCrossRefGoogle Scholar
  55. 14.
    Penny R, Castaldi PA, Whitsed HM (1971) Inflammation and haemostasis in paraproteinaemias. Br J Haematol 20: 35PubMedCrossRefGoogle Scholar
  56. 15.
    Pruzanski W, Watt JG (1972) Serum viscosity and hyperviscosity syndrome in IgG multiple myeloma. Ann Intern Med 77: 853PubMedCrossRefGoogle Scholar
  57. 16.
    Tuddenham EGD, Whittaker JA, Bradley J, Lilleyman JS, James DR (1974) Hyperviscosity syndrome in IgA multiple myeloma. Br J Haematol 27: 65PubMedCrossRefGoogle Scholar
  58. 17.
    Harbaugh ME, Hill EM, Conn RB (1975) Antithrombin and antithromboplastin activity accompanying IgG myeloma. Am J Clin Pathol 63: 57PubMedGoogle Scholar
  59. 18.
    Deutsch E, Neumann E, Niessner H (1976) Zur Pathogenese der hämorrhagischen Diathesen bei monoklonalen Gammopathien. In: Löffler H (Hrsg) Maligne Lymphome und monoklonale Gammopathien, Reihe: Hämatologie und Bluttransfusion, Bd 18. JF Lehmanns, München, S. 357Google Scholar
  60. 19.
    Roberts-Thomson PJ, Mason DY, Mac Lennan ICM (1976) Relationship between paraprotein polymerization and clinical features in IgA myeloma. Br J Haematol 33: 117PubMedCrossRefGoogle Scholar
  61. 20.
    Kasturi J, Saraya AK (1978) Platelet functions in dysproteinaemia. Acta Haematol (Basel) 59: 104CrossRefGoogle Scholar
  62. 21.
    McGrath KM, Stuart JJ, Richards F (1979) Correlation between serum-IgG, platelet membrane IgG and platelet function in hypergammaglobulinaemic states. Br J Haematol 42: 585PubMedCrossRefGoogle Scholar
  63. 22.
    Hedge UM, Powell DK, Bowes A, Gordon-Smith EC (1981) Enzyme linked immunoassay for the detection of platelet associated IgG. Br J Haematol 48: 39Google Scholar
  64. 23.
    Landolfi R, Leone G, Fedeli G, Storti S, Laghi F, Bizzi B (1980) Platelet associated IgG in acute and chronic hepatic diseases. Scand J Haematol 25: 417PubMedCrossRefGoogle Scholar
  65. 24.
    Mueller-Eckhardt C, Kayser W, Mersch-Baumert K, Mueller-Eckhardt G, Breidenbach M, Kugel H-G, Graubner M (1980) The clinical significance of platelet associated IgG: a study on 298 patients with various disorders. Br J Haematol 46: 123PubMedCrossRefGoogle Scholar
  66. 25.
    Kayser W (1981) Immunoglobulin G und Komplementfaktoren an menschlichen Thrombozyten: Pathogenetische, diagnostische und klinische Aspekte. Inaug.-Diss. GießenGoogle Scholar
  67. 26.
    Morse BS, Ginliani D, Nussbaum M (1981) Quantitation of Platelet-associated IgG by radial immunodiffusion. Blood 57: 809PubMedGoogle Scholar
  68. 27.
    Hedge UM, Williams K, Devereux S, Bowes A (1983) Platelet associated IgG and immune thrombocytopenia in lymphoproliferative and autoimmune disorders. Clin Lab Haematol 5: 9Google Scholar
  69. 28.
    Kelton JG, Giles AR, Neam PB, Powers P, Hageman N, Hirsh J (1980) Comparison of two direct assays for PAIgG in assessment of immune and nonimmune thrombocytopenia. Blood 55: 424PubMedGoogle Scholar
  70. 29.
    Kelton JG, Steeves K (1983) The amount of platelet-bound albumin parallels the amount of IgG on washed platelets from patients with immune thrombocytopenia. Blood 62: 924PubMedGoogle Scholar
  71. 30.
    Shulman NR, Leisinger CA, Hotchkiss AJ, Kautz CA (1983) The nonspecific nature of platelet-associated IgG. Trans Assoc Am Physicians 95: 213Google Scholar
  72. 31.
    Mueller-Eckhardt C, Schulz G, Sauer K-H, Dienst C, Mahn J (1978) Studies on the platelet radioactive immunoglobulin test. J Immunol Methods 19: 1PubMedCrossRefGoogle Scholar
  73. 32.
    Mueller-Eckhardt C, Mueller-Eckhardt G, Kayser W, Voss RM, Wegner J, Kiienzlen E (1982) Platelet associated IgG, platelet survival, and platelet sequestration in thrombocytopenic states. Br J Haematol 52: 49PubMedCrossRefGoogle Scholar
  74. 33.
    McGregor JL, Brochier J, Wild F, Follea G, Trzeciak MC, James E, Dechavanne M, McGregor L, Clemetson KJ (1983) Monoclonal antibodies against platelet membrane glycoproteins. Characterization and effect on platelet function. Eur J Biochem 131: 427Google Scholar
  75. 34.
    Scharf T, Santoso S, Rennich H, Heinrich D, Mueller-Eckhardt C (1984) Einfluß monoklonaler, Glykoprotein llb/Ills-and Zw(a)-spezifischer Antikörper auf die Plättchenfunktion. Blut (im Druck )Google Scholar
  76. 1.
    Born GVR, Cross MI (1963) The aggregation of blood platelets. J Physiol 168: 178–195PubMedGoogle Scholar
  77. 2.
    Breddin K, Bürck KH (1963) Zur Klinik der Thrombozytenfunktionsstörungen unter besonderer Berücksichtigung der Ausbreitungsfähigkeit der Thrombozyten an silikonisierten Glasflächen. Thromb Haemostas 9: 525–545Google Scholar
  78. 3.
    Crea F, Chierchia R, Caterina R de, Bernini W, Giannesi, Maseri A (1981) Antiplatelet effects of isosorbide dinitrate ( ISDN) in man. Eur Heart J (Suppl A) 2: 53Google Scholar
  79. 4.
    Levin RI, Jaffe EA, Weksler BB, Tack-Goldmann K (1981) Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells. J Clin Invest 67: 762–769PubMedCrossRefGoogle Scholar
  80. 5.
    Ring T, Knudsen F, Kristensen SD, Larsen CE (1983) Nitroglycerin prolongs the bleeding time in healthy males. Thromb Res 29: 553–559PubMedCrossRefGoogle Scholar
  81. 6.
    Schafer AI, Alexander RW, Handin RI (1980) Inhibition of platelet function by organic nitrate vasodilatators. Blood 55: 649–654PubMedGoogle Scholar
  82. 7.
    Schrör K, Grodzinska L, Darius H (1981) Stimulation of coronary vascular prostacyclin and inhibition of human platelet thromboxane A2 after low dose nitroglycerin. Thromb Res 23: 59–67PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • W. Klaubert
    • 1
  • C.-H. Bushe
    • 1
  • R. Hafter
    • 2
  • R. Gollwitzer
    • 3
  • W. Wilmanns
    • 1
  • H. Graeff
    • 2
  • T. H. Schöndorf
    • 4
  • L. Witt
    • 4
  • H. Pralle
    • 5
    • 10
  • A. Jobke
    • 5
  • D. Heinrich
    • 7
    • 10
  • T. Scharf
    • 6
  • S. Santoso
    • 6
  • C. Mueller-Eckhardt
    • 7
    • 13
  • C. M. Kirchmaier
    • 7
  • I. Arnold
    • 7
  • D. Rosenthal
    • 7
  • R. Brickl
    • 8
  • H. K. Breddin
    • 9
  • B.-J. Rasch
    • 10
  • M. Camerer
    • 11
  • R. H. Bödeker
    • 12
  • N. Bender
    • 14
  • W. Schneider
    • 14
  • D. Staufenbiel
    • 14
  • W. D. Bussmann
    • 14
  1. 1.Medizinische Klinik IIIKlinikum Großhadern der Universität MünchenDeutschland
  2. 2.FrauenklinikTechnischen UniversitätMünchenDeutschland
  3. 3.Max-Planck-Institut für BiochemieMünchen/MartinsriedDeutschland
  4. 4.Zentrum für Innere MedizinUniversität GießenDeutschland
  5. 5.KinderklinikUniversität Freiburg/BrsgDeutschland
  6. 6.Zentrum für Innere Medizin und Institut für Klinische ImmunologieTransfusionsmedizin am Klinikum der Justus-Liebig-UniversitätGießenDeutschland
  7. 7.Zentrum der Inneren MedizinAbt. Angiologie der Johann-Wolfgang-Goethe-UniversitätFrankfurt/MainDeutschland
  8. 8.Thomae GmbHBiberach/RißDeutschland
  9. 9.Frankfurt ZIMDeutschland
  10. 10.Zentrum für Innere MedizinDeutschland
  11. 11.Institut für klinische ImmunologieTransfusionsmedizinDeutschland
  12. 12.Institut für Medizinische InformatikDeutschland
  13. 13.Institut für klinische Immunologie und TransfusionsmedizinJustus-Liebig-UniversitätGießenDeutschland
  14. 14.Zentrum der Inneren Medizin, Abt. für AngiologieJohann-Wolfgang-von Goethe-UniversitätFrankfurt/MainDeutschland

Personalised recommendations