Zusammenfassung
Verlängerte Lebenszeiten und verbesserte Behandlungsmöglichkeiten für Tumorerkrankungen bringen es mit sich, daß paraneoplastische Phänomene wie Kalziumstoffwechselstörungen und Osteopathien häufiger zum Problem werden. Die aufmerksamer gewordenen Ärzte tragen dementsprechend Vorsorge, daß der Patient nicht durch derartige Komplikationen zusätzlich gefährdet wird.
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Literatur
Burkhardt E, Kistler HJ (1981) Hypercalciämie bei hospitalisierten Patienten. Schweiz Med Wochenschr 111: 2017–2023
Hickey RC, Samaan NA, Jackson GL (1981) Hypercalcemia in patients with breast cancer. Arch Surg 116: 545–552
Lafferty FW (1966) Pseudohyperparathyreoidism. Medicine (Baltimore) 45: 247–253
McDonnell GD, Dunstan CR, Evans RA, Carter JN, Hills E, Wong SYP, Mcneil DR (1982) Quantitative bone histology in the hypercalcemia of malignant disease. J Clin Endocrinol Metab 55: 1066–1072
Villalon AH, Tattersall HHN, Fox RM, Woods RL (1979) Hypercalcemia after tamoxifen for breast cancer: a sign of tumour response? Br Med J 2: 1329–1330
References
Binstock ML, Mundy GR (1980) Effects of calcitonin and glucocorticoids in combination in hypercalcemia of malignancy. Ann Intern Med 93: 269–272
Dominguez JH, Mundy GR (1980) Monocytes mediate osteoclastic bone resorption by prostaglandin production. Calcif Tissue Int 31: 29–34
Eilon G, Mundy GR (1978) Direct resorption of bone by human breast cancer cells in vitro. Nature 276: 726–728
Mundy GR, Luben RA, Raisz LG, Oppenheim JJ, Buell DN (1974) Bone-resorbing activity in supernatants from lymphoid cell lines. N Engl J Med 290: 867–871
Mundy GR, Raisz LG, Cooper RA, Schechter GP, Salmon SE (1974) Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med 291: 1041–1046
Mundy GR, Shapiro JL, Bandelin JG, Canalis EM, Raisz LC (1976) Direct stimulation of bone resorption by thyroid hormones. J Clin Invest 58: 529–534
Mundy GR, Altman AJ, Gondek M, Bandelin JG (1977) Direct resorption of bone by human monocytes. Science 196: 1109–1111
Mundy GR, Rick ME, Turcotte R, Kowalski MA (1978) Pathogenesis of hypercalcemia in lymphosarcoma cell leukemia – Role of an osteoclast activating factor-like substance and mechanism of action for glucocorticoid therapy. Am J Med 65: 600–606
Mundy GR, Varani J, Orr W, Gondek MD, Ward PA (1978) Resorbing bone is chemotactic for monocytes. Nature 275: 132–135
Mundy GR, Cove DH, Fisken R (1980) Primary hyperparathyroidism: Changes in the pattern of clinical presentation. Lancet 1: 1317–1320
Mundy GR, Raisz LG (1981) Disorders of bone resorption. In: Bronner F, Coburn JW (eds) Disorders of mineral metabolism, vol III. Academic Press, New York, pp 1–66
Mundy GR, Martin TJ (1982) Hypercalcemia of malignancy — Pathogenesis and treatment. Metabolism 31: 1247–1277
Mundy GR, Wilkinson R, Heath DA (1983) Comparative study of available medical therapy for hypercalcemia of malignancy. Am J Med 74: 421–432
Orr W, Varani J, Gondek MD, Ward PA, Mundy GR (1979) Chemotactic response of tumor cells to products of resorbing bone. Science 203: 176–179
Raisz LG, Luben RA, Mundy GR, Dietrich JW, Horton JE, Trummel CL (1975) Effect of osteoclast activating factor from human leukocytes on bone metabolism. J Clin Invest 56: 408–413
Strumpf M, Kowalski MA, Mundy GR (1978) Effects of glucocorticoids on osteoclast-activating factor. J Lab Clin Med 92: 772–778
Yoneda T, Mundy GR (1979) Monocytes regulate osteoclast-activating factor production by releasing prostaglandins. J Exp Med 150: 338–350
Literatur
Bockman RS (1980) Hypercalcemia in malignancy. Clin Endocrinol Metab 9: 317–333
Raskin P, McClain CJ, Medsger TA (1973) Hypocalcemia associated with metastatic bone disease. Arch Intern Med 132: 539–543
Stewart AF, Horst R, Deftos LJ, Cadman EC, Lang R, Broadus AE (1980) Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med 303: 1377–1383
Salassa RM, Jowsey J, Arnaud CD (1970) Hypophosphatemic osteomalacia associated with “nonendocrine” tumors. N Engl J Med 283: 65–70
Williams SJ, Green M, Kerr IH (1977) Detection of bone metastases in carcinoma of bronchus. Br Med J 1: 1004
Galasko CSP (1977) Skeletal metastases and mammary cancer. Ann R Coll Surg Engl 50: 3–28
Drezner MK, Lebovitz HE (1978) Primary hyperparathyroidism in paraneoplastic hypercalcemia. Lancet 2: 1004–1006
Hickey RC, Samaan NA, Jackson GL (1981) Hypercalcemia in patients with breast cancer. Osseous metastases, hyperplastic parathyroid tissue, or pseudo hyperparathyroidism? Arch Surg 116: 545–552
Benson RC, Riggs BL, Pickard BM, Arnaud CD (1974) Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease. Am J Med 56: 821–826
Lilienfeld-Toal H v, Niederle N, Keck E (1981) Elevated immunoreactive parathyroid hormone (iPTH) in normocalcemic lung cancer. Clin Res 29: 424A
Lilienfeld-Toal H v, Niederle N (1983) Increased immunoreactive parathyroid hormone in lung cancer (submitted)
Franck H, Hartlapp JH, Lilienfeld-Toal H v (1982) Increased set-point of parathyroid secretion induced by chronic hypercalcemia of non parathyroid reason. Eur J Clin Invest (Suppl) 12: 69
Seyberth HW, Segre GV, Morgan JL, Sweetman BJ, Potts JT, Oates JA (1975) Prostaglandins as mediators of hypercalcemia associated with certain types of cancer. N Engl J Med 293: 1278–1283
Brenner DE, Harvey HA, Lipton A, Demers L (1982) A study of prostaglandin E2, parathormone and response to indomethacin in patients with hypercalcemia of malignancy. Cancer 49: 556–561
Durie BGM, Salmon SE, Mundy GR (1981) Relation of osteoclast activating factor production to extent of bone disease in multiple myeloma. Br J Haematol 47: 21–30
Luben RA (1981) Evidence for the participation of osteoclast activating factor in disease processes in vivo. In: Cohn DV et al. (eds) Hormonal control of calcium metabolism. Excerpta Medica 315–321
Kukreja SC, Shemerdiak WP, Lad TE, Johnson PA (1980) Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer. J Clin Endocrinol Metab 51: 167–169
Literatur
Braunstein EM (1980) Non-Hodgkin disease of bone: Radiographic correlation with the histological classification. Radiology 137: 643–646
Dominok GW, Knoch HG (1977) Knochengeschwülste und geschwulstähnliche Knochenerkrankungen. Fischer, Jena
Freyschmidt J (1980) Knochenerkrankungen im Erwachsenenalter. Springer, Berlin Heidelberg New York
Spagnoli J, Gattoni F, Viganotti G (1982) Roentgenographic aspects of Non-Hodgkin-Lymphomas presenting with osseus lesions. Skeletal Radiol 8: 39–41
Uehlinger E (1981) Sekundäre Knochengeschwülste. In: Schinz HR et al. (Hrsg) Lehrbuch der Röntgendiagnostik. Thieme, Stuttgart New York
Literatur
Chabner BA, Johnson RE, Young RC, Canllos GP, Hubbard SP, Johnson SK, DeVita VT Jr (1976) Sequential nonsurgical and surgical staging of non-Hodgkin lymphoma. Ann Intern Med 85: 149–154
Chabner BA, Haskell CM, Canellos GP (1969) Destructive bone lesions in chronic granulocytic leukemia. Medicine (Baltimore) 48: 401–41
Cortes EP, Holland JF, Wang IJ, Glidewell O (1975) Adriamycin (NSC-123127) in 87 patients with osteogenic sarcoma. Cancer Chemother Rep 6: 305–313
Durie BGM, Salmon SE (1975) A clinical staging system for multiple myeloma. Cancer 36: 842–854
Gilbert HA, Kagan AR (1976) Metastases: incidence, detection, and evaluation without histologic confirmation. In: Weiss L (ed) Fundamental aspects of metastasis. North Holland Publ. Comp., Amsterdam Oxford, pp 385–406
Jaffe N (1972) Recent advances in the chemotherapy of metastatic osteogenic sarcoma. Cancer 30: 1627–1631
Henderson ES (1977) Acute leukemia: general considerations. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology, 2nd ed. McGraw-Hill, New York, pp 809–830
Kyle RA (1975) Multiple myeloma. Review of 869 cases. Mayo Clin Proc 50: 29–40
Lohrmann HP, Adam W, Heymer B, Kubanek B (1973) Microangiopathic hemolytic anemia in metastatic carcinoma. Report of eight cases. Ann Intern Med 79: 368–375
Newcomer LN, Silverstein MB, Cadman EC, Farber LR, Bertino JR, Prosnitz LR (1982) Bone involvement in Hodgkin’s disease. Cancer 49: 338–342
Ochs IJ, Freeman AI, Douglass HO Jr, Higby DS, Mindell ER, Sinks LF (1978) Cis-dichlorodiammine-platinum (II) in advanced osteogenic sarcoma. Cancer Treat Rep 62: 239–245
Pannuti F, Rossi AP, Marraro D, Strocchi E, Cricca A, Piana E, Pollutri E (1980) The natural history of cancer pain. In: Twycross RG, Ventafridda V (eds) The continuing care of terminal cancer patients. Pergamon Press, Oxford, pp 75–78
Poppe H (1976) Röntgenologische Frühdiagnostik. Orthop Praxis 10: 933–938
Pratt CB, Shanks EC, Hustu HO, Rivera G, Smith J, Mahesh Kumar AP (1977) Adjuvant multiple drug chemotherapy for osteogenic sarcoma of the extremity. Cancer 39: 51–57
Rosen G, Murphy ML, Huvos AG, Gutierrez A, Marcove R (1976) Chemotherapy, en bloc resection and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer 37: 1–11
Rosen G, Huvos AG, Mosende C, Beattie EJ, Exelby PR, Caparros B, Marcove RC (1978) Chemotherapy and thoracotomy for metastatic osteogenic sarcoma. A model for adjuvant chemotherapy and the rationale for the timing of thoracic surgery. Cancer 41: 841–849
Rosen G, Marcove RC, Caparros B, Nirenberg A, Kosloff C, Huvos AG (1979) Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery. Cancer 43: 2163–2177
Rosen G, Caparros B, Nirenberg A, Marcove RC, Huvos AG, Kosloff C, Lane J, Murphy ML (1981) Ewing’s sarcoma: Ten-Year experience with adjuvant chemotherapy. Cancer 47: 2204–2213
Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove RC, Lane JM, Mehta B, Urban C (1982) Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49: 1221–1230
Schreml W, Merkle W, Heimpel H (1981) Medikamentöse Schmerztherapie bei Krebspatienten. Med Klin 76: 43–47
Schreml W (1983) Supportive Maßnahmen bei der internistischen Tumorbehandlung: Schmerztherapie. In: Drings P, Schreml W (Hrsg) Supportive Maßnahmen in der internistischen Tumorbehandlung. W. Zuckschwerdt Verlag, München
Silverberg E (1982) Cancer statistics 1982. CA 32: 15–31
Sutow WW, Sullivan MP, Wilbur JR, Cangir A (1975) A study of adjuvant chemotherapy in osteogenic sarcoma. J Clin Pharmacol 7: 530–533
Thomas LB, Forkner CE, Frei E, Byron EB, Stabenau JR (1961) The skeletal lesions of acute leukemia. Cancer 14: 608–621
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Ziegler, R. et al. (1983). Symposium Knochenveränderungen bei malignen Tumoren. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_25
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