Skip to main content

Symposium Pathomechanismen der chronischen Niereninsuffizienz und Hämodialyse

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für innere Medizin

Zusammenfassung

Für die Anämie des progredienten Nierenversagens ist neben den bekannten Faktoren wie Mikroblutungen, Hämolyse und Erythropoetinmangel auch eine Störung der Regeneration der Erythrozyten verantwortlich. Sie wird möglicherweise durch den Inhibitor der In vivo- und In vitro-Erythropoese Spermin verursacht. Der renalen Anämie kann am wirksamsten durch die sorgfältige Begrenzung aller Blutverluste, einschließlich der diagnostischen Blutabnahmen, und gegebenenfalls durch eine adäquate, ausreichend lange Organersatztherapie begegnet werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bergström J, Fürst P (1978) Uremic toxins. Kidney Int (Suppl) 8: S9–S18

    Google Scholar 

  2. Campbell R et al. (1978) Polyamines, uremia, and hemodialysis. In: Campbell RA (ed) Polyamines, vol 2. Raven Press, New York, pp 319–344

    Google Scholar 

  3. Callen JR, Limarzi LR (1950) Blood and bone marrow studies in renal diseases. Am J Clin Pathol 20: 2–23

    Google Scholar 

  4. Erslev AJ (1953) Humoral regulation of red cell production. Blood 8: 349–357

    PubMed  CAS  Google Scholar 

  5. Jacobson LO et al. (1957) Role of the kidney in erythropoiesis. Nature 179: 633–645

    Article  PubMed  CAS  Google Scholar 

  6. Ohno Y et al. (1978) Inhibitors of erythroid colony forming cells (CFU-E and BFU-E) in sera of azotemic patients with anemia of renal disease. J Lab Clin Med 92: 916–923

    PubMed  CAS  Google Scholar 

  7. Radtke et al. (1979) Serum erythropoietin concentration in chronic renal failure: Relationship to degree of anemia and excretory renal function. Blood 54: 877–884

    PubMed  CAS  Google Scholar 

  8. Radtke et al. (1980) Improving anemia by hemodialysis: Effect on serum erythropoietin. Kidney Int 17: 382–387

    Article  PubMed  CAS  Google Scholar 

  9. Radtke et al. (1981) Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure. J Clin Invest 67: 1623–1631

    Article  PubMed  CAS  Google Scholar 

  10. Radtke et al. (1983) Polyamine induced in vivo and in vitro suppression of erythropoiesis in uremia. Haematologia (in press)

    Google Scholar 

Literatur

  1. Billman GE, Dickey DI, Teoh KK, Stone HL (1981) Effects of central venous blood volume shifts on arterial baroreflex control of heart rate. Am J Physiol (Heart Circ Physiol 10) 241: H571–H575

    CAS  Google Scholar 

  2. Blaustein MV (1977) Sodium ions, clacium ions, blood pressure regulation, and hypertension: A reassessment and a hypothesis. Am J Physiol 232: C165–C173

    PubMed  CAS  Google Scholar 

  3. Bogin E, Sechtjen E, Bristol G, Massry SG (1980) Parathyroid hormone and brain microsomal Na-K-activated ATPase. Mineral Electrolyte Metab 3: 104–108

    CAS  Google Scholar 

  4. Bohan T, Potter L, Bourgoignie JJ (1980) Ouabain radioreceptor assay for natriuretic factor. In: Lichardus B, Schrier RW, Ponec J (eds) Hormonal regulation of sodium excretion. Elsevier/North-Holland Biomedical Press, pp 393–397

    Google Scholar 

  5. Bourgoignie J, Hwang KH, Espinel C, Klahr S, Bricker NS (1972) A natriuretic factor in the serum of patients with chronic uremia. J Clin Invest 51: 1514–1527

    Article  PubMed  CAS  Google Scholar 

  6. Bourgoignie J, Klahr S, Bricker NS (1971) Inhibition of transepithelial sodium transport in the frog skin by a low molecular weight fraction of uremic serum. J Clin Invest 50: 303–311

    Article  PubMed  CAS  Google Scholar 

  7. Bricker NW (1967) The control of sodium excretion with normal and reduced nephron populations. Am J Med 43: 313–321

    Article  PubMed  CAS  Google Scholar 

  8. Bricker NS (1972) On the pathogenesis of the uremic state. An exposition of the „Trade-off Hypothesis“. N Engl J Med 286: 1093–1099

    Article  PubMed  CAS  Google Scholar 

  9. Bricker NS, Klahr S, Purkerson M, Schultze RG, Avioli LV, Birge SJ (1968) In vitro assay for a humoral substance present during volume expansion and uraemia. Nature 219: 1058–1059

    Article  PubMed  CAS  Google Scholar 

  10. Brod J, Bahlmann J, Cachovan M, Pretschner P (1983) Development of hypertension in renal disease. Clin Sci 64: 141–152

    PubMed  CAS  Google Scholar 

  11. Brown AM (1980) Receptors under pressure. An update on baroreceptors. Circ Res 46: 1–10

    PubMed  CAS  Google Scholar 

  12. Campese VM, Romoff MS, Levitan D, Lande K, Massry SG (1981) Mechanism of autonomic nervous system dysfunction in uremia. Kidney Int 20: 246–253

    Article  PubMed  CAS  Google Scholar 

  13. Chen HI, Chai CY, Tung CS, Chen HC (1979) Modulation of the carotid baroreflex function during volume expansion. Am J Physiol (Heart Circ Physiol 6) 237: H153–H158

    CAS  Google Scholar 

  14. Cole CH (1973) Decreased ouabain-sensitive adenosine triphosphatase activity in the erythrocyte membrane of patients with chronic renal disease. Clin Sci Mol Med 45: 775–784

    PubMed  CAS  Google Scholar 

  15. Dahl LK, Knudsen KD, Heine M, Leitl G (1969) Effects of chronic excess salt ingestion: Genetic influences on the development of salt hypertension in parabiotic rats: evidence for a humoral factor. J Exp Med 130: 1353–1365

    Article  PubMed  Google Scholar 

  16. Davis JC, Johnston CI, Howards SS, Wright FS (1967) Humoral factors in the regulation of renal sodium excretion. Fed Proc 26: 60–69

    PubMed  CAS  Google Scholar 

  17. De Wardener HE, Mills JH, Clapham WF, Hayter CJ (1961) Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin Sci 21: 249–258

    Google Scholar 

  18. De Wardener HE, Clarkson EM, Bitensky L, MacGregor GA, Alaghband-Zadeh J, Chayen J (1981) Effect of sodium intake on ability of human plasma to inhibit renal Na+-K+-adenosine triphosphatase in vitro. Lancet 1: 411–412

    Article  PubMed  Google Scholar 

  19. De Wardener HE, MacGregor GA (1980) Dahl’s hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: Its possible role in essential hypertension. Kidney Int 18: 1–9

    Article  PubMed  Google Scholar 

  20. Edmondson RPS, Thomas RD, Hilton PJ, Patrick J, Jones NF (1975) Abnormal leucocyte composition and sodium transport in essential hypertension. Lancet 1: 1003–1005

    Article  PubMed  CAS  Google Scholar 

  21. Favre H, Gourjon M (1982) Absence of production of natriuretic factor following acute saline expansion in nephrotic rats. Clin Sci 63: 317–319

    PubMed  CAS  Google Scholar 

  22. Fiehn W, Seiler D, Heimberg KW (1976) Transport ATPases of cardiac sarcolemma in experimental uremia. Clin Chim Acta 73: 93–96

    Article  PubMed  CAS  Google Scholar 

  23. Fine LG, Bourgoignie JJ, Hwang KH, Bricker NS (1976) On the influence of the natriuretic factor from patients with chronic uremia on the biolectric properties and sodium transport of the isolated mammalian collecting tubule. J Clin Invest 58: 590–597

    Article  PubMed  CAS  Google Scholar 

  24. Flanigan WJ, Anderson DS, Stout K, Koike TI (1978) Site of action of a uremic serum fraction inhibiting sodium transport in frog skin. Nephron 22: 117–123

    Article  PubMed  CAS  Google Scholar 

  25. Francavilla A, Albano O, Mastrangelo F, Coratelli P, Palasciano G, Amerio A (1972) Erythrocyte membrane ATPase in patients with acute or chronic renal disease. Clin Chim Acta 37: 298–300

    Article  PubMed  CAS  Google Scholar 

  26. Gessler U (1961) Intra- und extracelluläre Elektrolytveränderungen bei metabolischer Acidose. Untersuchungen an Erythrocyten. Klin Wochenschr 39: 232–238

    Article  PubMed  CAS  Google Scholar 

  27. Gonick HC, Kramer HJ, Paul W, Lu E (1977) Circulating inhibitor of sodium-potassium-activated adenosine triphosphatase after expansion of extracellular fluid volume in rats. Clin Sci Mol Med 53: 329–334

    PubMed  CAS  Google Scholar 

  28. Gruber KA, Whitaker JM, Buckalew VM Jr (1980) Endogenous digitalis-like substance in plasma of volume-expanded dogs. Nature 287: 743–745

    Article  PubMed  CAS  Google Scholar 

  29. Haddy FJ, Overbeck HW (1976) The role of humoral agents in volume expanded hypertension. Life Sci 19: 935–948

    Article  PubMed  CAS  Google Scholar 

  30. Haddy FJ, Pamnani MB, Clough DL (1980) Volume overload hypertension: A defect in the sodium-potassium pump? Cardiovasc Rev Rep 1: 376–385

    Google Scholar 

  31. Haupert GT Jr, Sancho JM (1979) Sodium transport inhibitor from bovine hypothalamus. Proc Natl Acad Sci USA 76: 4658–4660

    Article  PubMed  CAS  Google Scholar 

  32. Hillyard SD, Lu E, Gonick HC (1976) Further characterization of the natriuretic factor derived from kidney tissue of volume-expanded rats. Effects on short-circuit current and sodium-potassium-adenosine triphosphatase activity. Circ Res 38: 250–255

    PubMed  CAS  Google Scholar 

  33. Kaplan MA, Bourgoignie JJ, Rosecan J, Bricker NS (1974) The effects of the natriuretic factor from uremic urine on sodium transport, water and electrolyte content, and pyruvate oxidation by the isolated toad bladder. J Clin Invest 53: 1568–1577

    Article  PubMed  CAS  Google Scholar 

  34. Klingmüller D, Weiler E, Kramer HJ (1982) Digoxin-like natriuretic activity in the urine of salt loaded healthy subjects. In: Kramer HJ, Krück F (eds) Molecular basis of tubular transport and of the action of diuretics. Klin Wochenschr 60: 1249–1253

    Google Scholar 

  35. Koch KM, Baldamus CA, Ernst W, Fassbinder W, Georges J, Brecht HM (1980) Autonome Kreislaufregulation in der Urämie. Klin Wochenschr 58: 1037–1042

    Article  PubMed  CAS  Google Scholar 

  36. Kramer HJ (1981) Natriuretic hormone — A circulating inhibitor of sodium- and potassium-activated adenosine triphosphatase. Its potential role in body fluid and blood pressure regulation. Klin Wochenschr 59: 1225–1230

    Article  PubMed  CAS  Google Scholar 

  37. Kramer HJ (1975) Natriuretic hormone—its possible role in fluid and electrolyte disturbances in chronic liver disease. Postgrad Med J 51: 532–540

    Article  PubMed  CAS  Google Scholar 

  38. Kramer HJ, Bäcker A, Krück F (1974) Inhibition of intestinal (Na+-K+)-ATPase in experimental uremia. Clin Chim Acta 50: 13–18

    Article  PubMed  CAS  Google Scholar 

  39. Kramer HJ, Bäcker A, Krück F (1977) Antinatriferic activity in human plasma following acute and chronic salt loading. Kidney Int 12: 214–222

    Article  PubMed  CAS  Google Scholar 

  40. Kramer HJ, Gonick HC, Paul W, Lu E (1969) Third factor: Inhibitor of Na-K-ATPase? Presented at the IVth. Int. Congr. Nephrology, Abstracts I (free Communications), p 373

    Google Scholar 

  41. Kramer HJ, Gonick HC, Krück F (1972) Natriuretisches Hormon. Klin Wochenschr 50: 893–897

    Article  PubMed  CAS  Google Scholar 

  42. Kramer HJ, Gonick HC (1974) Effect of extracellular volume expansion on renal Na-K-ATPase and cell metabolism. Nephron 12: 281–296

    Article  PubMed  CAS  Google Scholar 

  43. Kramer HJ, Gospodinov D, Krück F (1976) Functional and metabolic studies on red blood ceel sodium transport in chronic uremia. Nephron 16: 344–358

    Article  PubMed  CAS  Google Scholar 

  44. Kramer HJ, Gospodinov B, Krück F (1974) Humorale Hemmung des epithelialen Natrium-Transportes nach akuter Expansion des Extracellularvolumens: Weitere Untersuchungen zur Existenz eines natriuretischen Hormons. Klin Wochenschr 52: 801–808

    Article  PubMed  CAS  Google Scholar 

  45. Krück F, Kramer HJ (1978) Third factor and edema formation. Contrib Nephrol 13: 12–20

    PubMed  Google Scholar 

  46. Lichardus B, Pearce JW (1966) Evidence for a humoral natriuretic factor released by blood volume expansion. Nature 209: 407–409

    Article  PubMed  CAS  Google Scholar 

  47. Minkoff L, Gaertner G, Darab M, Mercier C, Levin ML (1972) Inhibition of brain sodium-potassium ATPase in uremic rats. J Lab Clin Med 80: 71–78

    PubMed  CAS  Google Scholar 

  48. Möhring J, Glänzer K, Maciel JA Jr, Düsing R, Kramer HJ, Arbogast R, Koch-Weser J (1980) Greatly enhanced pressor response to antidiuretic hormone in patients with impaired cardiovascular reflexes due to idiopathic orthostatic hypotension. J Cardiovasc Pharmacol 2: 367–376

    Article  PubMed  Google Scholar 

  49. Postnov YV, Orlov SN, Shevchenko A, Adler AM (1977) ATPase activity in the red blood cell membrane in essential hypertension. Pfluegers Arch 371: 263–269

    Article  CAS  Google Scholar 

  50. Poston L, Sewell RB, Wilkinson SP, Richardson PJ, Williams R, Clarkson EM, MacGregor GA, de Wardener HE (1981) Evidence for a circulating sodium transport inhibitor in essential hypertension. Br Med J 282: 847–849

    Article  CAS  Google Scholar 

  51. Raghavan RRV, Gonick HC (1980) Partial purification and characterization of natriuretic factor from rat kidney. Proc Soc Exp Biol Med 164: 101 – 104

    PubMed  CAS  Google Scholar 

  52. Skou JC (1965) Enzymatic basis for active transport of Na and K across cell membranes. Physiol Rev 45: 596–617

    PubMed  CAS  Google Scholar 

  53. Smith HW (1957) Salt and water volume receptors: an exercise in physiologic apologetics. Am J Med 23: 623–652

    Article  PubMed  CAS  Google Scholar 

  54. Van den Noort S, Eckel S, Brine S, Hrdlika JT (1968) Brain metabolism in uremic and adenosine infused rats. J Clin Invest 47: 2133–2142

    Article  Google Scholar 

  55. Villamil MF, Rettori V, Kleeman CR (1968) Sodium transport by red blood cells in uraemia. J Lab Clin Med 72: 308–317

    PubMed  CAS  Google Scholar 

  56. Walter U, Distler A (1982) Abnormal sodium efflux in erythrocytes of patients with essential hypertension. Hypertension 4: 205–210

    PubMed  CAS  Google Scholar 

  57. Weber H, Bourgoignie JJ, Bricker NS (1974) The effects of the natriuretic fraction from human uremic serum on proximal tubular sodium reabsorption in the rat. Am J Physiol 226: 419–425

    PubMed  CAS  Google Scholar 

  58. Welt LG, Sachs JR, McMannus TJ (1964) An ion transport defect in erythrocytes of uraemic patients. Trans Assoc Am Physicians 77: 169

    PubMed  CAS  Google Scholar 

  59. Wessels F (1970) Untersuchungen des Elektrolytstoffwechsels der Erythrozyten bei chronischer Niereninsuffizienz. J Clin Chem Clin Biochem 8: 278–283

    CAS  Google Scholar 

  60. Wright FS, Davis JO, Johnston CJ, Howards SS (1968) Renal sodium excretion after volume expansion with saline and blood. Proc Soc Exp Biol Med 128: 1044–1051

    CAS  Google Scholar 

References

  1. Coburn JW, Kurokawa K, Llach F (1980) Altered divalent ion metabolism in renal disease and renal osteodystrophy. In: Maxwell MH, Kleeman CR (eds) Clinical disorders of fluid and electrolyte metabolism. McGraw-Hill Book Co., New York, pp 1153–1250

    Google Scholar 

  2. Slatopolsky E, Martin K, Hruska K (1980) Parathyroid hormone metabolism and its potential as a uremic toxin. Am J Physiol 239: F1–F12

    PubMed  CAS  Google Scholar 

  3. Olgaard K, Arbelaez M, Schwartz J, Klahr S, Slatopolsky E (1982) Calcif Tissue Int 34: 304–407

    Article  Google Scholar 

  4. Massry SG, Goldstein DA (1979) The search for uremic toxin(s) „X“: „X“ = PTH. Clin Nephrol 11: 181–186

    PubMed  CAS  Google Scholar 

  5. Massry SG (1982) Does parathyroid hormone play the role of a uremic toxin in patients with chronic renal failure? In: Hamburger J, Crosnier J, Grünfeld JP, Maxwell MH (eds) Advances in nephrology, vol 11. Year Book Medical Publ. Inc., New York, pp 223–240

    Google Scholar 

  6. Lhoste F, Drüeke T, Larno S, Boissier JR (1980) Cardiac interaction between parathyroid hormone, beta adrenoceptor, and verapamil in the guinea pig in vitro. Clin Exp Pharmacol Physiol 7: 119–127

    Article  PubMed  CAS  Google Scholar 

  7. Drüeke T, Fauchet M, Fleury J, Lesourd P, Toure Y, Le Pailleur C, De Vernejoul P, Crosnier J (1980) Effect of parathyroidectomy on left ventricular function in haemodialysis patients. Lancet 1: 112–114

    Article  PubMed  Google Scholar 

  8. Basile C, Lacour B, Drüeke T, Boffa G-A, Funck-Brentano J-L (1982) Parathyroid function and erythrocyte production in the rat. Mineral Electrol Metab 7: 197–206

    CAS  Google Scholar 

  9. Zingraff J, Drüeke T, Marie P, Man NK, Jungers P, Bordier P (1978) Anemia and secondary hyperparathyroidism. Arch Intern Med 138: 1650–1652

    Article  PubMed  CAS  Google Scholar 

  10. Lacour B, Basile C, Drüeke T, Funck-Brentano JL (1982) Parathyroid function and lipid metabolism in the rat. Mineral Electrol Metab 7: 157–165

    CAS  Google Scholar 

  11. Drüeke T, Lacour B, Jorgetti V, Thévenin M, Poirier A, Dubost C (1983) Disturbances of lipid metabolism in patients with secondary (renal) or primary hyperparathyroidism (abstract). Kidney Int 23:98

    Google Scholar 

  12. Drüeke T, Lacour B, Basile C, Bourdon R, Funck-Brentano JL (1981) Effects of uremia, hyperparathyroidism, and active vit. D metabolites on hepatic aluminium (Al) accumulation in orally Al intoxicated rats (abstract). VIIIth Internat. Congress of Nephrology, Athens

    Google Scholar 

  13. Cournot-Witmer G, Zingraff J, Plachot JJ, Bourdeau A, Garabédian M, Escaig F, Lefèvre R, Galle P, Bourdon P, Drüeke T, Balsan S (1981) Aluminum localization in bone from hemodialyzed patients: relationship to matrix mineralization. Kidney Int 20: 375–385

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Aasen AO, Ohlsson K (1978) Release of granulocyte elastase in lethal canine endotoxin shock. Hoppe-Seylers Z Physiol Chem 359: 683–690

    PubMed  CAS  Google Scholar 

  2. Bendall JR, Taylor AA (1970) The Meyerhof quotient and the synthesis of glycogen from lactate in frog and rabbit muscle. A reinvestigation. Biochem J 118: 887–893

    CAS  Google Scholar 

  3. Birkhahn RH, Long LC, Fitkin D, Jeevanandam M, Blakemore WS (1981) Whole-body protein metabolism due to trauma in man as estimated by L-(15N) alanine. Am J Physiol 241: E64–E71

    PubMed  CAS  Google Scholar 

  4. Blondin J, Janoff A (1976) The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes. J Clin Invest 58: 971–979

    Article  PubMed  CAS  Google Scholar 

  5. Blumenkrantz MJ, Roberts C, Card B, Coburn JW, Kopple JD (1978) Nutritional management of the adult patient undergoing peritoneal dialysis. Am J Dietet ASSOC 73: 251–260

    CAS  Google Scholar 

  6. Cohen P (1973) The subunit structure of rabbit skeletal muscle phosphorylase kinase and the molecular basis of its activation reactions. Eur J Biochem 34: 1–14

    Article  PubMed  CAS  Google Scholar 

  7. Conger JD, Hammond WS, Alfrey AC, Contiguglia SR, Huffer WE, Stanford RE (1975) Pulmonary calcification in chronic dialysis patients: clinical and pathological studies. Ann Intern Med 83: 330–336

    PubMed  CAS  Google Scholar 

  8. Crabtree B, Higgins SJ, Newsholme EJ (1972) The activities of pyruvate carboxylase, phosphoenolpyruvate carboxylase and fructose diphosphatase in muscles from vertebrates and invertebrates. Biochem J 130: 391–396

    PubMed  CAS  Google Scholar 

  9. Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacob HS (1977) Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. J Clin Invest 59: 879–888

    Article  PubMed  CAS  Google Scholar 

  10. Craddock PR, Hammerschmidt DE, White JG, Dalmasso AP, Jacob HS (1977) Complement (C5a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostatis and leukopenia. J Clin Invest 60: 260–264

    Article  PubMed  CAS  Google Scholar 

  11. Crane CW, Picou D, Smith R, Waterlow JC (1977) Protein turnover in patients before and after elective orthopedic operations. Br J Surg 64: 129–133

    Article  PubMed  CAS  Google Scholar 

  12. DeFronzo RA (1978) Pathogenesis of glucose intolerance in uremia. Metabolism 27: 1866–1880

    Article  PubMed  CAS  Google Scholar 

  13. DeFronzo RA, Alvestrand A (1980) Glucose intolerance in uremia: site and mechanism .Am J Clin Nutr 33: 1438–1445

    PubMed  CAS  Google Scholar 

  14. DeFronzo RA, Felig P (1980) Amino acid metabolism in uremia: insights gained from normal and diabetic man. Am J Clin Nutr 33: 1378–1386

    PubMed  CAS  Google Scholar 

  15. DeFronzo RA, Tobin JD, Rowe JW, Andres R (1978) Glucose intolerance in uremia: Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. J Clin Invest 62: 425–435

    Article  PubMed  CAS  Google Scholar 

  16. Djovkar A, Hörl WH, Heidland A (1983) Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats. Nephron 34: 164–167

    Article  PubMed  CAS  Google Scholar 

  17. Egbring R, Schmidt W, Fuchs G, Havemann K (1977) Demonstration of granulocyte proteases in plasma of patients with acute leukemia and septicemia with coagulation defects. Blood 49: 219–231

    PubMed  CAS  Google Scholar 

  18. Emmanouel DS, Lindheimer MD, Katz AI (1980) Role of the kidney in hormone metabolism and its implications in clinical medicine. Klin Wochenschr 58: 1005–1012

    Article  PubMed  CAS  Google Scholar 

  19. Farrell P, Hone P (1980) Dialysis-induced catabolism. Am J Clin Nutr 33: 1417–1422

    PubMed  CAS  Google Scholar 

  20. Fröhlich J, Hoppe-Seyler G, Schollmeyer P, Meier K, Gerok W (1977) Possible sites of interaction of acute renal failure with amino acid utilisation for gluconeogensis in isolated perfused rat liver. Eur J Clin Invest 7: 261–268

    Article  PubMed  Google Scholar 

  21. Fröhlich J, Schollmeyer P, Gerok W (1978) Carbohydrate metabolism in renal failure. Am J Clin Nutr 31: 1541–1546

    PubMed  Google Scholar 

  22. Fürst P, Alvestrand A, Bergström J (1980) Effects of nutrition and catabolic stress on intracellular amino acid pools in uremia. Am J Clin Nutr 33: 1387–1395

    PubMed  Google Scholar 

  23. Garber AJ, Karl IE, Kipnis DM (1976) Alanine and glutamine synthesis and release from skeletal muscle. IV. β-adrenergic inhibition of amino acid release. J Biol Chem 251: 851–856

    PubMed  CAS  Google Scholar 

  24. Gotch F, Borah M, Keen M, Sargent J (1977) The solute kinetics of intermittent dialysis therapy (IDT). Proc Annu Contractors Conf Artif Kidney Program, vol 10. NIAMDD, Washington, pp 105–111

    Google Scholar 

  25. Graves DJ, Hayakawa T, Horovitz RA, Beckmann E, Krebs EG (1973) Studies on the subunit structure of trypsin-activated phosphorylase kinase. Biochemistry 12: 580–585

    Article  PubMed  CAS  Google Scholar 

  26. Hällgren R, Venge P, Wilström B (1981) Hemodialysis-induced increase in serum lactoferrin and serum eosinopil cationic protein as signs of local neutrophil and eosinophil degranulation. Nephron 29: 233–238

    Article  PubMed  Google Scholar 

  27. Haverberg LN, Omstedt PI, Munro HN, Young VR (1975) N-methylhistidine content of mixed proteins in various rat tissues. Biochem Biophys Acta 405: 67–71

    PubMed  CAS  Google Scholar 

  28. Heidland A, Hörl WH, Heller N, Heine H, Neumann S, Heidbreder E (1983) Proteolytic enzymes and catabolism — enhanced release of granulocyte proteinases in uremic intoxication and during hemodialysis. Kidney Int (in press)

    Google Scholar 

  29. Hörl WH, Gantert C, Auer IO, Heidland A (1982) In vitro inhibition of protein catabolism by alpha2-macroglobulin in plasma from a patient with posttraumatic acute renal failure. Am J Nephrol 2: 32–35

    Article  PubMed  Google Scholar 

  30. Hörl WH, Heidland A (1980) Enhanced proteolytic activity — cause of protein catabolism in acute renal failure. Am J Clin Nutr 33: 1423–1427

    PubMed  Google Scholar 

  31. Hörl WH, Heidland A (1980) Glycogen metabolism in muscle in uremia. Am J Clin Nutr 33: 1461–1467

    PubMed  Google Scholar 

  32. Hörl WH, Jochum M, Heidland A, Fritz H (1983) Release of granulocyte proteinases during hemodialysis. Am J Nephrol (in press)

    Google Scholar 

  33. Hörl WH, Stepinski J, Gantert C, Hörl M, Heidland A (1981) Evidence for the participation of proteases on protein catabolism during hypercatabolic renal failure. Klin Wochenschr 59: 751–759

    Article  PubMed  Google Scholar 

  34. Hörl WH, Stepinski J, Heidland A (1980) Carbohydrate metabolism and uraemia — mechanisms for glycogenolysis and gluconeogenesis. Klin Wochenschr 58: 1051–1064

    Article  PubMed  Google Scholar 

  35. Hörl WH, Stepinski J, Schäfer RM, Heidland A (1983) Role of proteases in hypercatabolic patients with renal failure. Kidney Int (in press)

    Google Scholar 

  36. Hörl M, Hörl WH, Heidland A (1982) Proteinkatabolismus und Tourniquet-Schock: Rolle proteolytischer Enzyme. Chirurg 53: 253–257

    PubMed  Google Scholar 

  37. Janoff A, Blondin J, Sandhaus RA, Mosser A, Malemud CJ (1975) Human neutrophil elastase: in vitro effects on natural substrates suggest important physiological and pathological action. In: Reich E et al. (eds) Proteases and biological control. Cold Spring Harbor Laboratory, Cold Spring Harbor, p 603

    Google Scholar 

  38. Janoff A, Scherer J (1968) Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 128: 1137–1155

    Article  PubMed  CAS  Google Scholar 

  39. Kaplow LW, Goffinet JA (1968) Profound neutropenia during the early phase of hemodialysis. JAMA 203: 1135–1137

    Article  PubMed  CAS  Google Scholar 

  40. Kien CL, Young VR, Rohrbauch DK, Burke JF (1978) Increased rates of whole body protein synthesis and breakdown in children recovering from burn. Ann Surg 187: 383–391

    Article  PubMed  CAS  Google Scholar 

  41. Klessen C (1978) On testing the activity of proteases from human polymorphonuclear neutrophiles on blood smears. J Biochem Cytochem 26: 759–760

    Article  CAS  Google Scholar 

  42. Klessen C, Tekolf W (1980) Cytochemical investigation of neutral proteases in polymorphonuclear (PMN) neutrophiles in acute inflammatory diseases. Histochemistry 69: 307–314

    Article  PubMed  CAS  Google Scholar 

  43. Kono T, Barham FW (1971) The relationship between the insulin binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells. J Biol Chem 246: 6210–6216

    PubMed  CAS  Google Scholar 

  44. Kopple JD (1976) Metabolic and endocrine abnormalities: C. Nitrogen metabolism. In: Massry SC, Sellers A (eds) Clinical aspects of uremia and dialysis. Charles C. Thomas, Springfield, pp 241–273

    Google Scholar 

  45. Kopple JD, Jones M, Fukuda S, Swendseid ME (1978) Amino acid and protein metabolism in renal failure. Am J Clin Nutr 31: 1532–1540

    PubMed  CAS  Google Scholar 

  46. Kopple JD, Swendseid ME, Shinaberger JH, Umezawa CY (1973) The free and bound amino acids removed by hemodialysis. Trans Am Soc Artif Intern Organs 19: 309–313

    Article  PubMed  CAS  Google Scholar 

  47. Krebs EG, Love DW, Bratvold GE, Trayser KA, Meyer WL, Fischer EH (1964) Purification and properties of rabbit skeletal muscle phosphorylase b kinase. Biochemistry 3: 1022–1033

    Article  PubMed  CAS  Google Scholar 

  48. Lazarus GS, Daniels JR, Brown RS, Bladen HA, Fullmer HM (1968) Degradation of collagen by a human collagenolytic system. J Clin Invest 47: 2622–2628

    Article  PubMed  CAS  Google Scholar 

  49. Long CL, Jeevanandam M, Kim BM, Kinney JM (1977) Whole body protein synthesis and catabolism in septic man. Am J Clin Nutr 30: 1340–1344

    PubMed  CAS  Google Scholar 

  50. Maillet C, Garber AJ (1980) Skeletal muscle amino acid metabolism in chronic uremia. Am J Clin Nutr 33: 1343–1353

    PubMed  CAS  Google Scholar 

  51. Munro HN, Young VR (1978) Urinary excretion of N-methylhistidine (3-methylhistidine): a tool to study metabolic responses in relation to nutrient and hormonal status in health and disease of man. Am J Clin Nutr 31: 1608–1614

    PubMed  CAS  Google Scholar 

  52. Neumann S, Hennrich N, Gunzer G, Lang H (1983) Enzyme-linked immunoassay for human granulocyte α1-proteinase inhibitor complex. In: Goldberg W (ed) Progress in clinical enzymology, II. Masson Publ., New York (in press)

    Google Scholar 

  53. Ohlsson K, Olsson J (1973) The neutral proteases of human granulocytes. Isolation and partial characterization of two granulocyte collagenases. Eur J Biochem 36: 473–481

    Article  PubMed  CAS  Google Scholar 

  54. O’Keefe SJD, Sender PM, James WPT (1974) „Catabolic“ loss of body nitrogen in response to surgery. Lancet 2: 1035–1038

    Article  PubMed  Google Scholar 

  55. Rall TW, Sutherland EW (1958) Formation of a cyclic adenine ribonucleotide by tissue particles. J Biol Chem 232: 1065–1076

    PubMed  CAS  Google Scholar 

  56. Riegel W, Stepinski J, Hörl WH, Heidland A (1982) Effect of hormones on hepatocyte gluconeogenesis in different models of acute uraemia. Nephron 32: 67–72

    Article  PubMed  CAS  Google Scholar 

  57. Rindler R, Schmalzl F, Braunsteiner H (1974) Isolierung und Charakterisierung der chymotrypsinähnlichen Protease aus neutrophilen Granulozyten des Menschen. Schweiz Med Wochenschr 104: 132–133

    PubMed  CAS  Google Scholar 

  58. Ritz E, Mehls O, Gilli G, Heuck CC (1978) Protein restriction in the conservative management of uremia. Am J Clin Nutr 31: 1703–1711

    PubMed  CAS  Google Scholar 

  59. Ruderman NB, Houghton CRS, Hems R (1971) Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J 124: 639–651

    PubMed  CAS  Google Scholar 

  60. Schäfer RM, Hörl WM, Heidland A (1982) Isolation of protein glycogen complexes from rat skeletal muscle in acute uremia: Role of serine. Proc Soc Exp Biol Med 169: 519–526

    PubMed  Google Scholar 

  61. Smolen JE, Weissmann G (1978) The granulocyte: Metabolic properties and mechanisms of lysosomal enzyme release. In: Havemann K, Janoff A (eds) Neutral proteases of human polymorphonuclear leukocytes. Urban and Schwarzenberg Inc., Baltimore Munich, p 423

    Google Scholar 

  62. Stepinski J, Hörl WH, Heidland A (1982) The gluconeogenetic ability of hepatocytes in various types of acute uraemia. Nephron 31: 75–81

    Article  PubMed  CAS  Google Scholar 

  63. Walser M (1975) Ketoacids in the treatment of uremia. Clin Nephrol 3: 180–186

    PubMed  CAS  Google Scholar 

  64. Wathen R, Keshaviah P, Hommeyer P, Cadwell K, Comty C (1977) Role of dialysate glucose in preventing gluconeogenesis during hemodialysis. Trans Am Soc Artif Intern Organs 23: 393–398

    Article  PubMed  CAS  Google Scholar 

  65. Wysocki H, Czarnecki R, Wierusz-Wysocka B, Wykretowicz A, Wysocki K, Baczyk K (1981) The selective polymorphonuclear neutrophils (PMN) degranulation as the probable additional mechanism of the hemodialysis (HD)-induced complement activation. Int J Art Org 4: 174–177

    CAS  Google Scholar 

Literatur

  1. Spitz IM, Rubenstein AH, Bersohn I, Abrahams C, Lowy C (1970) Carbohydrate metabolism in renal disease. Q J Med 39: 201–226

    PubMed  CAS  Google Scholar 

  2. Bilbrey GL, Faloona GR, White MG, Knochel JP (1974) Hyperglucagonemia of renal failure. J Clin Invest 53: 841–847

    Article  PubMed  CAS  Google Scholar 

  3. Massry SG, Coburn JW, Lee DBN, Jowsey J, Kleeman R (1973) Skeletal resistance to parathyroid hormone in renal failure. Study in 105 human subjects. Ann Intern Med 78: 357–364

    PubMed  CAS  Google Scholar 

  4. Silva OL, Becker KL, Shalhoub RJ, Snider RH, Bivins LE, Moore CF (1977) Calcitonin levels in chronic renal disease. Nephron 19: 12–18

    Article  PubMed  CAS  Google Scholar 

  5. Geisthövel W, von zur Mühlen A, Bahlmann J (1976) Untersuchungen über die Hypophysen-Testesfunktion bei chronisch nierenkranken Männern mit unterschiedlicher Glomerularfunktion. Klin Wochenschr 54: 1027–1037

    Article  PubMed  Google Scholar 

  6. Brecht HM, Ernst W, Koch KM (1975) Plasma noradrenaline levels in regular hemodialysis patients. Proc Eur Dial Transplant Assoc 12: 281–291

    Google Scholar 

  7. Henrich WL, Katz FH, Molinoff PB, Schrier RW (1977) Competitive effects of hyperkalemia and volume depletion on plasma renin activity, aldosterone and catecholamine concentrations in hemodialysed patients. Kidney Int 12: 277–284

    Article  Google Scholar 

  8. Ksiazek A (1979) Beta dopamine hydroxylase activity and catecholamine levels in the plasma of patients with renal failure. Nephron 24: 170–174

    Article  PubMed  CAS  Google Scholar 

  9. Rascher W, Schömig A, Kreye VA, Ritz E (1981) Diminished vascular response to noradrenaline in experimental chronic uremia. Kidney Int 21: 20–27

    Article  Google Scholar 

  10. Ulman A, Drüeke T, Zingraff J, Crosnier J (1977) The response of heart rate to isoproterenol in hemodialysed patients before and after parathyroidectomy. Clin Nephrol 7: 58–60

    Google Scholar 

  11. Brodde OE, Daul A, Graten N (1983) Decreased number of alpha-adrenergic receptors in platelets of patients on maintenance hemodialysis. Proc Eur Dial Transplan Assoc 19: 270–274

    CAS  Google Scholar 

  12. Kreußer W, Mader H, Haag W-D, Ritz E (1982) Ovarian cAMP response to luteinizing hormone is diminished in experimental uremia. Kidney Int 22: 272–279

    Article  PubMed  Google Scholar 

  13. Merke J, Kreußer W, Bier B, Ritz E (1983) Demonstration and characterisation of a testicular 1,25-Dihydroxyvitamin D3 receptor in the rat. Eur J Biochem (in press)

    Google Scholar 

  14. Kreußer W, Weinkauff R, Mehls O, Ritz E (1982) Effect of parathyroid hormone, calcitonin and growth hormone on cAMP content of growth cartilage in experimental uremia. Eur J Clin Invest 12: 337–343

    Article  PubMed  Google Scholar 

  15. Llach F, Massry SG, Singer FR, Kurokawa K, Kaye JH, Coburn JW (1975) Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure. A possible cause for secondary hyperparathyroidism. J Clin Endocrinol Metab 41: 339–345

    Article  PubMed  CAS  Google Scholar 

  16. Oda Y, Kurokawa K, Aznar E, Kreußer WJ, Massry SG (1981) Effect of parathyroid hormone on cyclic AMP and cyclic AMP-dependent protein kinase activity in calvaria of acutely uremic rats. Mineral Electrol Metab 6: 210–216

    CAS  Google Scholar 

Literatur

  1. Ackrill P, Ralston HJ, Day JP, Hodge KC (1980) Successful removal of aluminum from patients with dialysis encephalopathy. Lancet 2: 692–693

    Article  PubMed  CAS  Google Scholar 

  2. Alfrey AC, Mishell JB, Burks J, Contiguglia SR, Rudolph H, Lewin E, Holmes JH (1972) Syndrome of dyspraxia and multifocal seizures associated with chronic hemodialysis. Trans Am Soc Artif Intern Organs 18: 257–261

    Article  PubMed  CAS  Google Scholar 

  3. Alfrey AC, LeGendre GR, Kaehny WD (1976) The dialysis encephalopathy syndrome. N Engl J Med 294: 184–188

    Article  PubMed  CAS  Google Scholar 

  4. Alfrey AC, Hegg A, Miller N, Berl T, Berns A (1972) Interrelationship between calcium and aluminum metabolism in dialyzed uremic patients. Mineral Electrol Metab 2: 81–87

    Google Scholar 

  5. Berlyne GM, Ben-Ari J, Pest D, Wennberger J, Gilmore GR, Levine R (1970) Hyperaluminemia from aluminum resin in renal failure. Lancet 2: 494–496

    Article  PubMed  CAS  Google Scholar 

  6. Berlyne GM, Yagil R, Ben-Ari J (1972) Aluminum toxicity in rats. Lancet 1: 564–568

    Article  PubMed  CAS  Google Scholar 

  7. Berlyne GM (1979) Aluminum toxicity in man. Mineral Electrol Metab 2: 71

    CAS  Google Scholar 

  8. Brown DJ, Dawborn JK, Ham KN, Xipell JM (1982) Treatment of dialysis osteomalacia with desferrioxamine. Lancet 1: 343–345

    Article  Google Scholar 

  9. Crapper DR, Krishmann SS, Dalton AJ (1973) Brain aluminium distribution in Alzheimer disease and experimental neurofibrillary degeneration. Science 180: 511

    Article  PubMed  CAS  Google Scholar 

  10. Clarkson EM, Luck VA, Hynson WV, Bailey RR, Eastwood JB, Woodhead JS, Clements VR, O’Riordan JLH, DeWardener HE (1972) The effect of aluminiumhydroxyde on calcium, phosphorus and aluminium balance the serum parathormone concentration and the aluminium content of bone in patients with chronic renal failure. Clin Sci 43: 519

    PubMed  CAS  Google Scholar 

  11. Cornells R (1982) Variability in reported plasma Al-concentrations. Int. Workshop on: The role of biological monitoring in the prevention of aluminium toxicity in man. Commission of the European Communities, Luxembourg, 5–7 July, 1982

    Google Scholar 

  12. Cournot-Witmer G, Zingragg J, Plackot JJ, Bourdeau A, Garabidiau M, Essay F, Lefebre R, Galle P, Bourdon R, Drüeke T, Bolsam S (1981) Aluminum localisation in bone from hemodialyzed patients. Relationship to matrix mineralisation. Kidney Int 20: 375–385

    Article  PubMed  CAS  Google Scholar 

  13. Disler P, Day R, Pascoe M, Blekkenhorst G, Eales L (1981) The role of aluminum in dialysis related porphyria cutanea tarda. Abst. 8th International Congress of Nephrology, p 252

    Google Scholar 

  14. Drüeke T (1980) Dialysis osteomalacic and aluminium intoxication. Nephron 26: 207–210

    Article  PubMed  Google Scholar 

  15. Ellis HA (1982) Aluminum and renal osteodystrophy in patients and animals. 4. Nephrol. Seminar der III. Med. Klinik, Allg. Krankenhaus Bamberg. 12./13. Nov. 1982

    Google Scholar 

  16. Ellis HA, McCarthy JH, Herrington J (1979) Bone aluminum in hemodialyzed patients and in rats injected with aluminum chloride: relationship to impaired bone mineralisation. J Clin Pathol 32: 832–844

    Article  PubMed  CAS  Google Scholar 

  17. Elliot HL, MacDougall AT (1978) Aluminum studies in dialysis encephalopathy. Proc Eur Dial Transplant Assoc 15: 157

    Google Scholar 

  18. Flendrig JA, Kruis H, Das HA (1976) Aluminum intoxication the cause of dialysis dementia? In: Robinson BHB (ed) Dialysis transplantation nephrology, vol. 13. Pitman Medical, p 355

    Google Scholar 

  19. Knoll O, Graefe U, Bertram HP, Zumkley H (1981) Häufigkeit und Verlauf der Aluminium-bedingten Anämie, Osteopathie und Encephalopathie bei 92 Heimdialysepatienten. In: XV Symposium der Gesellschaft für Nephrologie

    Google Scholar 

  20. Knoll O (1981) Diagnostik der progressiven Dialyseencephalopathie. In: Zumkley H (Hrsg) Aluminium in der Nephrologie-Dialyseencephalopathie. Dustrie-Verlag, Dr. Karl Feistle, München

    Google Scholar 

  21. Kopeloff IM, Barrera S, Kopeloff N (1972) Recurrent convulsive seizures in animals produced by immunologic and chemical means. Am J Psychiatr 98: 881

    Google Scholar 

  22. Kaehny WD, Hegg HP, Alfrey AC (1977) Gastrointestinal absorption of aluminum from aluminum containing antacid. N Engl J Med 286: 1389

    Article  Google Scholar 

  23. Mayor GH, Keiser JH, Mahdami D, Ku PK (1977) The aluminum absorption and distribution: effect of parathyroid hormone. Science 197: 1187–1189

    Article  PubMed  CAS  Google Scholar 

  24. McLaughlin AIG, Kazantzis G, King E (1962) Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminum dust. J Intern Med 19: 253

    CAS  Google Scholar 

  25. Ott SM, Maloney NA, Coburn JW, Alfrey AC, Sherrarad DJ (1982) The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy. N Engl J Med 12: 709

    Article  Google Scholar 

  26. O’Hara JA, Murnaghan DJ (1982) Reversal of aluminum induced hemodialysis anemia by a low-aluminum dialysate. N Engl J Med 306: 654

    Article  Google Scholar 

  27. Parsons U, Davies C, Goode C (1971) Aluminum in bone from patients with renal failure. Br Med J 4: 273–275

    Article  PubMed  CAS  Google Scholar 

  28. Parkinson IS, Ward MK, Teest TG, Fawcett RWP, Kerr DNS (1979) Fracturing dialysis osteodystrophy and dialysis encephalopathy. Lancet 1: 406

    Article  PubMed  CAS  Google Scholar 

  29. Platts MM, Goode GC, Hislop JS (1977) Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis. Br Med J 2: 657–660

    Article  PubMed  CAS  Google Scholar 

  30. Pogglitsch H, Wawschinek O, Holzer H, Petek W, Katschnik H, Ladurner G (1980) Beziehungen zwischen Plasmaaluminium, peroraler Aluminiumhydroxydaufnahme und Encephalopathiesymptomen bei Dauerdialysepatienten. Nieren-Hochdruckkrankh 9: 284

    Google Scholar 

  31. Ulmer DD (1976) Toxicity from aluminum antacids. N Engl J Med 294: 218

    Article  PubMed  CAS  Google Scholar 

  32. Ward MK, Pierides AM, Fawcett P, Shaw DA, Perry R, Kerr DN (1976) Dialysis encephalopathy syndrome. In: Robinson BHB (ed) Dialysis, transplantation, nephrology, vol. 13. Pitmann Medical, p 348

    Google Scholar 

  33. Zumkley H, Bertram HP, Lison A, Knoll O, Schulz S, Losse H (1979) Das Verhalten der Aluminiumkonzentration im Plasma bei chronischer Niereninsuffizienz. Therapiewoche 29: 1129

    Google Scholar 

  34. Zumkley H, Bertram HP, Lison A, Knoll O, Losse H (1979) Aluminium, zinc and copper concentrations in plasma in chronic renal insufficiency. Clin Nephrol 12: 18

    PubMed  CAS  Google Scholar 

  35. Zumkley H, Bertram HP, Lison A (1978) Aluminium, zinc and magnesium abnormalities in renal insufficiency. XIXth International Congress of Internal Medicine. ISIM, Rome 1978

    Google Scholar 

  36. Zumkley H, Bertram HP, Lison A, Ernst G (1979) Oral administration of MG and Al during renal insufficiency. In: Hemphill DD (ed) Trace substances in environmental health, 12. ed. Columbia University, Miss.

    Google Scholar 

  37. Zumkley H, Bertram HP, Graefe U, Langer K (1980) Sources of high aluminum levels in chronic hemodialyzed patients. In: Hemphill DD (ed) Trace substances in environmental health, 13. ed. Columbia University, Miss.

    Google Scholar 

  38. Zumkley H, Schmidt PF, Vetter H, Elies M (1983) Determination of magnesium concentrations in RBC by laser-microprobe-mass-analysis (LAMMA). J Am Col Nutr 4: 418–419

    Google Scholar 

  39. Zumkley H (1981) Klinische Aspekte des Aluminiumhaushaltes. In: Zumkley H (Hrsg) Aluminium in der Nephrologie. Dustrie-Verlag, Dr. Karl Feistle, München

    Google Scholar 

  40. Zumkley H, Knoll O, Graefe U, Bertram HP (1983) Klinik der Dialyse-Encephalopathie (im Druck)

    Google Scholar 

Literatur

  1. Anastassiades S, Sheriff M, Platts D, Bartolo D (1981) Splenomegaly in patients receiving regular hemodialysis. Kidney Int 19: 619a

    Article  Google Scholar 

  2. Bommer J, Waldherr R, Gastner M, Lemmes R, Ritz E (1981a) Iatrogenic multiorgan silicone inclusions in dialysis patients. Klin Wochenschr 59: 1149–1157

    Article  CAS  Google Scholar 

  3. Bommer J, Ritz E, Waldherr R (1981b) Silicone-induced splenomegaly. Treatment of pancytopenia by splenectomy in a patient of hemodialysis. N Engl J Med 305: 1077–1079

    Article  PubMed  CAS  Google Scholar 

  4. Bommer J, Waldherr R, Ritz E, Rambausek M, Kessler W (1982a) Organablagerungen von Partikeln aus Dialyseschläuchen — eine tierexperimentelle Studie. Nieren-Hochdruckkrankh 11: 218

    Google Scholar 

  5. Bommer J, Gemsa D, Waldherr R, Ritz E (1983) Macrophage activation by particles released from dialysis tubing. Kidney Int 23: 143

    Google Scholar 

  6. Blum M, Tchetchik M, Schujman E, Aviram A (1981) Liver enlargement in long-term hemodialysis patients. Ann Intern Med 140: 343–344

    Article  Google Scholar 

  7. Ellenbogen R, Ellenbogen R, Rubin L (1975) Injectable fluid silicone therapy: Human morbidity and mortality. JAMA 234: 308–309

    Article  PubMed  CAS  Google Scholar 

  8. Fiegenberg DS, DeColli JA, Lisan PR (1969) Fracture of a Starr-Edwards aortic ball valve with systemic embolism of ball fragments. Am J Cardiol 23: 458–463

    Article  PubMed  CAS  Google Scholar 

  9. Laohapand T, Osman EM, Morley AR, Ward ML, Kerr DNS (1982) Accumulation of silicone elastomer in regular dialysis. Proc Eur Dial Transplant Assoc 19: 143–152

    Google Scholar 

  10. Leong ASA, Path MRC, Disney APS, Gove DW (1982) Spallatin and migration of silicone from blood-pump tubing in patients on hemodialysis. N Engl J Med 306: 135–136

    Article  PubMed  CAS  Google Scholar 

  11. Noon GF, Harrell JE, Feldman L, Peterson J, Kent PM, De Bakey ME (1983) Development and evaluation of pulsatile roller pump and tubing for cardiac assistance. Artif Organs 7: 49–54

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Aizawa Y, Ohmori T, Imai K, Nara Y, Matsuoka M, Hirasawa Y (1977) Depressant action of acetate upon the human cardiovascular system. Clin Nephrol 8: 480

    Google Scholar 

  2. Baldamus CA, Ernst W, Frei U, Koch KM (1982) Sympathetic and hemodynamic response to volume removal during different forms of renal replacement therapy. Nephron 31: 324–332

    Article  PubMed  CAS  Google Scholar 

  3. Baldamus CA, Ernst W, Kachel HG, Lysaght M, Koch KM (1982) Hemodynamics in hemofiltration. Contrib Nephrol 32: 56–60

    PubMed  CAS  Google Scholar 

  4. Brodde OE, Daul A, Graben N (1982) Decreased number of alpha-adrenergic receptors in platelets of patients on maintenance haemodialysis. Proc Eur Dial Transplant Assoc 19: 270–274

    CAS  Google Scholar 

  5. Campese VM, Romoff MS, Levitan D, Lane K, Massry SG (1981) Mechanisms of autonomic nervous system dysfunction in uremia. Kidney Int 20: 246–253

    Article  PubMed  CAS  Google Scholar 

  6. Craddock PR, Fehr J, Brigham KL, Kronenberg RS, Jacob HS (1977) Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis. N Engl J Med 296: 769–774

    Article  PubMed  CAS  Google Scholar 

  7. Degoulet P, Proulx J, Aimé F, Berger C, Bloch P, Goupy F, Legrain M (1976) Programme dialyse-informatique III — Données épidémiologiques. Stratégies de dialyse et résultats biologiques. J Urol Néphrol 82: 1001–1042

    Google Scholar 

  8. Dolan MJ, Whipp BJ, Davidson WD, Weitzman RE, Wasserman K (1981) Hypopnea associated with acetate hemodialysis: carbon dioxide-flow-dependent ventilation. N Engl J Med 305: 72–75

    Article  PubMed  CAS  Google Scholar 

  9. Ewing DJ, Winney R (1975) Autonomic function in patients with chronic renal failure on intermittent haemodialysis. Nephron 15: 424–429

    Article  PubMed  CAS  Google Scholar 

  10. Gotch FA (1983) Sodium volume modeling of hemodialysis (HD) and hemofiltration (HF) therapy. Clin Dial Transplant Forum 10: 31 (abstracts)

    Google Scholar 

  11. Kersh ES, Kronfield SJ, Unger A, Popper RW, Cantor S, Cohn K (1974) Autonomic insufficiency in uremia as a cause of hemodialysis induced hypotension. N Engl J Med 290: 650–653

    Article  PubMed  CAS  Google Scholar 

  12. Keshaviah P, Shapiro FL (1982) A critical examination of dialysis-induced hypotension. Am J Kidney Dis 2: 290–301

    PubMed  CAS  Google Scholar 

  13. Kirkendol PL, Devia CJ, Bower JD, Holbert RD (1977) A comparison of the cardiovascular effects of sodium acetate, sodium bicarbonate and other potential sources of fixed base in hemodialysate solution. Trans Am Soc Artif Intern Organs 23: 399–405

    Article  PubMed  CAS  Google Scholar 

  14. Koch KM, Baldamus CA, Ernst W, Fassbinder W, Georges J, Brecht HM (1980) Autonome Kreislaufregulation in der Urämie. Klin Wochenschr 58: 1037–1042

    Article  PubMed  CAS  Google Scholar 

  15. Mansell MA, Crowther A, Laker MF, Wing AJ (1982) The effect of hyperacetatemia on cardiac output during regular hemodialysis. Clin Nephrol 18: 130–134

    PubMed  CAS  Google Scholar 

  16. Nies AS, Robertson D, Stone WJ (1979) Hemodialysis hypotension is not the result of uremic peripheral autonomic neuropathy. J Lab Clin Med 94: 395–402

    PubMed  CAS  Google Scholar 

  17. Novello A, Kelsch RC, Easterling RC (1976) Acetate intolerance during hemodialysis. Clin Nephrol 5: 29–32

    PubMed  CAS  Google Scholar 

  18. Oh MS, Uribarri JV, Del Monte ML et al. (1979) Consumption of CO2 in metabolism of acetate as an explanation for hypoventilation and hypoxemia during hemodialysis. Proc Clin Dial Transplant Forum 9: 226–229

    PubMed  CAS  Google Scholar 

  19. Oh MS, Heneghan WF, Kee CS et al. (1981) Glucose ameliorates hypoxemia and reduction in respiratory quotient induced by infusion of sodium acetate. Am Soc Nephrol (abstract), p 48A

    Google Scholar 

  20. Rascher W, Schömig A, Freye VA, Ritz E (1982) Diminished vascular response to noradrenaline in experimental chronic uremia. Kidney Int 21: 20–27

    Article  PubMed  CAS  Google Scholar 

  21. Röckel A, Hennemann H, Sternagel-Haase A, Heidland A (1979) Uraemic sympathetic neuropathy after haemodialysis and transplantation. Eur J Clin Invest 9: 23–27

    Article  PubMed  Google Scholar 

  22. Rubin LJ, Gutman RA (1978) Hypotension during haemodialysis. Kidney 11: 21–24

    Google Scholar 

  23. Soriano G, Eisinger RP (1972) Abnormal response to the Valsava maneuver in patients on chronic hemodialysis. Nephron 9: 251–256

    Article  PubMed  CAS  Google Scholar 

  24. Tyler HR (1974) Uremic neuritis and the autonomic system. N Engl J Med 290: 685–686

    Article  PubMed  CAS  Google Scholar 

  25. Wathen RL (1977) The impact of acetate and bicarbonate containing dialysate on hydrogen ion balance. Proc Renal Physicians Assoc 1: 19–24

    Google Scholar 

  26. Wathen RL, Ward RA, Harding GB et al. (1982) Acid-base and metabolic responses to anion infusion in the anesthetized dog. Kidney Int 21: 592–599

    Article  PubMed  CAS  Google Scholar 

  27. Wehle B, Asaba H, Castenfors J et al. (1981) Influence of dialysate composition on cardiovascular function in isoosmotic hemodialysis. Proc Eur Dial Transplant Assoc 18: 153–158

    PubMed  CAS  Google Scholar 

  28. Zuccala A, Degli Esposti E, Sturani A, Chiarini C, Santoro A, Catizone L, Zuccelli P (1978) Autonomic function in hemodialyzed patients. Int J Artif Organs 1: 76–82

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 J. F. Bergmann Verlag, München

About this paper

Cite this paper

Radtke, H.W. et al. (1983). Symposium Pathomechanismen der chronischen Niereninsuffizienz und Hämodialyse. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85456-9_24

  • Publisher Name: J.F. Bergmann-Verlag

  • Print ISBN: 978-3-8070-0335-1

  • Online ISBN: 978-3-642-85456-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics