Zusammenfassung
Veränderungen des Aggregationsverhaltens und der TZ-Überlebenszeit bei Patienten mit KHK wurden von Mehta et al. (1980) mit einer gesteigerten Endoperoxidsynthese der TZ in Zusammenhang gebracht. Hirsh et al. (1981) und Tada et al. (1981) haben bei KHK im Anschluß an durch atriale Stimulation induzierte Angina pectoris erhöhte Thromboxanwerte im Koronarsinus gemessen. Unter der Fragestellung, ob bei KHK Veränderungen der Aktivitäten der an der Thromboxansynthese beteiligten Enzymsysteme in den TZ bestehen, haben wir den Stoffwechsel exogener 14-C-Arachidonsäure untersucht. Außerdem wurde die TZ-Aggregation nach Kollagen und die dadurch induzierte TXB2-Synthese sowie die Prostazyklinsensitivität der TZ bestimmt.
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© 1983 J. F. Bergmann Verlag, München
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Jaschonek, K. et al. (1983). Hämostaseologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_21
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