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Endokrinologie

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Book cover Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 89))

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Zusammenfassung

Thyreoglobulin (Tg) ist ein jodiertes Glykoprotein mit einem Molekulargewicht von 660 000 Dalton. Es wird ausschließlich in den Thyreozyten gebildet und nach Jodierung und Synthese der Schilddrüsenhormone an der apikalen Thyreozytenmembran in den Schilddrüsenfollikeln gespeichert [2]. Unter TSH-Stimulation kommt es zur Phagozytose von Tg, durch lysosomale Enzyme werden die Schilddrüsenhormone abgespalten und in die Blutbahn abgegeben [8]. Der weitere Weg des Tg ist bisher nicht geklärt. Wahrscheinlich wird es teilweise weiter enzymatisch abgebaut, aber auch eine Sekretion von Tg zusammen mit den Schilddrüsen-hormonen in die Zirkulation wird postuliert [8]. Nachdem nämlich empfindliche radioim-munologische Bestimmungsmethoden für Serum-Tg entwickelt worden waren [7, 13], fand man bei nahezu alien Schilddrüsengesunden Tg-Spiegel je nach Bestimmungsmethode zwischen 10 und 43 ng/ml [10, 11]. In mehreren Untersuchungen, vor aliem aus der Arbeitsgruppe von van Herle et al. [8], konnte eine Abhängigkeit der Tg-Spiegel von der TSH-Stimulation der Schilddrüse gezeigt werden [8, 14]. Hieraus wurde gefolgert, daß Tg, ähnlich den Schilddrüsenhormonen, ein normales Sekretionsprodukt der Schilddrüse darstellt. Der Abbau des Serum-Tg erfolgt, wie bei nahezu alien Glykoproteinen, über die Leber, die Halbwertszeit beträgt etwa 48–72 Std.

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Literatur

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Authors and Affiliations

  1. Med. Klinik Innenstadt der Univ. München, Deutschland

    R. Gärtner, G. Bechtner, A. Hainzinger, I. Marschner, K. Horn & C. R. Pickardt

  2. Zentrum der Inneren Medizin, Deutschland

    P.-M. Schumm, K. H. Usadel, U. Schwedes & W. D. Strohm

  3. Zentrum der Radiologie, Deutschland

    F. D. Maul

  4. Zentrum der Inneren Medizin, Klinikum der Univ. Frankfurt, Deutschland

    K. Schöffling

  5. Abt. für klin. Endokrinologie, Med. Klinik und Poliklinik, Univ.-Klinikum Essen, Deutschland

    T. Olbricht, T. Schmitka, H.-U. Mellinghoff, G. Benker & D. Reinwein

  6. Med. Klinik und Poliklinik B, Münster, Deutschland

    K. Hengst, U. Wenning, T. Hossdorf, C. Karoff & H. Wagner

  7. III. Med. Klinik und Poliklinik der Univ. Gießen, Deutschland

    H. Stracke & H. Schatz

  8. Med. Klinik des Univ.-Spitals Zürich, Switzerland

    J. Zapf

  9. I. Med. Univ.-Klinik Wien, Österreich

    H. Vierhapper

  10. Med. Univ.-Poliklinik Bonn, Deutschland

    D. Klingmüller, D. Menger, G. Leyendecker, L. Wildt, F. Krück & H. U. Schweikert

  11. Innere Medizin I., Univ. Ulm, Deutschland

    W. D. Hetzel, O. Castillo, L. Aberle & E. F. Pfeiffer

  12. Med. Klinik Innenstadt der Univ. München, Deutschland

    C. R. Pickardt, O. A. Müller, S. Schmidbauer & G. Thoenes

  13. Med. Klinik C der Univ. Düsseldorf, Deutschland

    H. K. Kley, A. Müller & H. L. Krüskemper

  14. Med. Klinik Innenstadt und Radiolog, Poliklinik der Univ. München, Deutschland

    T. Eversmann, A. Bucher, L. Bock, B. Leisner & K. von Werder

  15. Abt. Endokrinologie, Med. Poliklinik Heidelberg, Deutschland

    G. Holz, F. Raue, C. Smith & R. Ziegler

  16. Abt. für Anästhesie und Intensivmedizin, Univ. Gießen, Deutschland

    S. Hartenfels

  17. Med. Klinik der Univ. Marburg, Deutschland

    F. Eberle

  18. Med. Klinik der Univ. Gießen, Deutschland

    A. Käbisch & H. Pralle

  19. Inst. für klinische Chemie und Pathobiochemie Gießen, Deutschland

    B. Klabuhn

  20. Med. Univ.-Klinik Göttingen, Deutschland

    G. Hintze, H. Dirks & J. Köbberling

  21. Chirurg. Univ.-Klinik Göttingen, Deutschland

    H. D. Becker

  22. Med. Klinik II, Klinikum Großhadern, München, Deutschland

    R. Hörmann, R. Müller, K. Mann, G. Reichel & H.-J. Karl

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  1. R. Gärtner
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Editors and Affiliations

  1. Kliniken der Landeshauptstadt Wiesbaden, Wiesbaden, D-6200, Deutschland

    Bernhard Schlegel

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© 1983 J. F. Bergmann Verlag, München

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Gärtner, R. et al. (1983). Endokrinologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-85456-9_20

  • Publisher Name: J.F. Bergmann-Verlag

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