Skip to main content

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 89))

  • 27 Accesses

Zusammenfassung

Die intraerythrozytäre Ferritinkonzentration ist zusätzlich zur Serum- bzw. Plasmaferritin-konzentration [9] für die Beurteilung des Eisenhaushalts geeignet [3]. Bei latentem Eisenmangel ist die Ferritinkonzentration in den Erythrozyten im Gegensatz zu der im Plasma überwiegend normal [3], fällt aber hochsignifikant bei manifester Eisenmangelanämie ab [3, 13].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Beamish MR, Walker R, Miller F, Worwood M, Jacobs A, Williams R, Corrigall A (1974) Transferrin iron, chelatable iron and ferritin in idiopathic haemochromatosis. Br J Haematol 27: 219–228

    Article  PubMed  CAS  Google Scholar 

  2. Birgegård G, Högman C, Killander A, Levander H, Simonsson B, Wide L (1977) Serum ferritin and erythrocyte 2,3 DPG during quantitated phlebotomy and iron treatment. Scand J Haematol 19:327–333

    Article  PubMed  Google Scholar 

  3. Bodemann HH, Rieger A, Löhr GW (1982) Intraerythrozytäre Ferritinkonzentration und Eisenbestand. Verh Dtsch Ges Inn Med 88:993–995

    Google Scholar 

  4. Bomford AB, Munro HN (1980) Biosynthesis of ferritin and isoferritins. In: Jacobs A, Worwood M (eds) Iron in biochemistry and medicine, II. Academic Press, London New York, pp 173–202

    Google Scholar 

  5. Drews J, Düllmann J, Hausmann K, Kuse R (1980) Die Serumferritinbestimmung in Diagnostik und Therapie der Eisenüberladung. In: Kaltwasser JP, Werner E (Hrsg) Serumferritin. Springer, Berlin Heidelberg New York, S 194–210

    Google Scholar 

  6. Finch CA, Huebers H (1982) Perspectives in iron metabolism. N Engl J Med 306: 1520–1528

    Article  PubMed  CAS  Google Scholar 

  7. Jacobs A (1980) The pathology of iron overload. In: Jacobs A, Worwood M (eds) Iron in biochemistry and medicine, II. Academic Press, London New York, pp 427–459

    Google Scholar 

  8. Kaltwasser JP, Werner E, Becker HJ (1977) Serumferritin als Kontrollparameter bei oraler Eisentherapie. Dtsch Med Wochenschr 102: 1150–1155

    Article  PubMed  CAS  Google Scholar 

  9. Lipschitz DA, Cook JD, Finch CA (1974) A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 290: 1213–1216

    Article  PubMed  CAS  Google Scholar 

  10. Schaefer FV, Theil EC (1981) The effect of iron on the synthesis and amount of ferritin in red blood cells during ontogeny. J Biol Chem 256: 1711–1715

    PubMed  CAS  Google Scholar 

  11. Wheby MS (1980) Effect of iron therapy on serum ferritin levels in iron-deficiency anemia. Blood 56:138–140

    PubMed  CAS  Google Scholar 

  12. Worwood M (1980) Serum ferritin. In: Jacobs A, Worwood M (eds) Iron in biochemistry and medicine, II. Academic Press, London New York, pp 203–244

    Google Scholar 

  13. Yamada H (1978) Characterization of serum and red cell ferritin in hematological disorders. Acta Haematol Jpn 41:1334–1338

    CAS  Google Scholar 

  14. Zähringer J (1980) Struktur und Funktion von Ferritin. In: Kaltwasser JP, Werner E (Hrsg) Serumferritin. Springer, Berlin Heidelberg New York, S 1–22

    Google Scholar 

Literatur

  • Dunn CDR, Jarois JH, Greenman JM (1975) A quantitative bioassay for erythropoietin using mouse foetal liver cells. Exp Hematol 3: 365

    Google Scholar 

  • Heilmann E, Holzknecht A, Fahrenkrug H (1981) Hinweise auf einen hämatopoetisch wirksamen Faktor im Serum von Patienten mit Polycythaemia vera. Verh Dtsch Ges Inn Med 87: 772

    Google Scholar 

  • Heilmann E, Ridderskamp P, Maurer HR (1982) A micromethod to culture hematopoietic colonies in glass capillaries. Exp Hematol 10: 146

    Google Scholar 

  • Iscove NN, Scun JS, Till JS, McCulloh EA (1971) Colony formation by normal and leukemic human marrow cells in culture, effect of conditioned medium from human leukocytes. Blood 37: 1

    PubMed  CAS  Google Scholar 

  • Kansal V, Sood SK, Batra AK, Adhar G, Malviya AK, Kucheria K, Balakrishnan K (1979) Fetal liver transplantation in aplastic anemia. Acta Haematol (Basel) 62:128

    Article  CAS  Google Scholar 

Literatur

  • Aster RH (1966) Pooling of platelets in the spleen: Role in the pathogenesis of “hypersplenic” thrombocytopenia. J Clin Invest 45:645–657

    Article  PubMed  CAS  Google Scholar 

  • Korinth E (1962) Untersuchungen über die quantitativen morphologischen und funktionellen Veränderungen der Thrombozyten bei chronischen Lebererkrankungen. Acta Hepatogastroenterol (Stuttg) 9:65–73

    CAS  Google Scholar 

  • Leone G et al. (1981) Mega-thrombocytes, platelet regeneration time and platelet associated IgG in idiopathic thrombocytopenic purpura and in thrombocytopenia associated with chronic liver disease. Acta Haematol (Basel) 65: 40–47

    Article  CAS  Google Scholar 

  • Pennington DG, Streatfield K (1975) Megacaryocytes and the heterogeneity of circulating platelets. Br J Haematol 34: 639–653

    Article  Google Scholar 

  • Penny R, Rozenberg MC, Firkin BG (1966) The splenic platelet pool. Blood 27:1–16

    PubMed  CAS  Google Scholar 

  • Scharf RE, Heisig S, Winkelmann M, Schneider W (1983) Erhöhte thrombozytäre Sialinsäurekonzentration bei Leberzirrhose. Verh Dtsch Ges Inn Med 89:990

    Google Scholar 

  • Siemensma NP, Bathal PS, Pennington PG (1975) The effect of massive liver resection on platelet kinetics in the rat. J Lab Clin Med 86: 817–833

    PubMed  CAS  Google Scholar 

  • Stein SF, Harker LA (1982) Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis. J Lab Clin Med 99:217–230

    PubMed  CAS  Google Scholar 

Literatur

  • Brozović M (1981) Aquired disorers of blood coagulation. In: Bloom AL, Thomas DP (eds) Haemostasis and thrombosis. Churchill Livingstone, Edinburgh, pp 411–438

    Google Scholar 

  • Deutsch E (1982) Hämostasestörungen bei Lebererkrankungen. Bildungsstörungen. Verh Dsch Ges Inn Med 88:1330–1335

    Google Scholar 

  • Mannucci PM, Mari D (1981) Hemostasis and liver disease. Haematologica (Pavia) 66: 233–248

    CAS  Google Scholar 

  • Martinez J, Kwasniak D (1977) Role of sialic acid in the dysfibrinonenaemia associated with liver disease. Thromb Haemostas 38:169 (Abstract)

    Google Scholar 

  • Rubin MH, Weston MJ, Langley PG, White Y, Williams R (1979) Platelet function in chronic liver disease. Relationship to disease severity. Dig Dis Sci 24:197–202

    Article  PubMed  CAS  Google Scholar 

  • Schneider W, Scharf RE, Schramm W (1982) Hämostasestörungen bei Lebererkrankungen. Thrombozyten und Lebererkrankungen. Verh Dtsch Ges Inn Med 88:1336–1339

    Google Scholar 

  • Soria J, Soria S, Samana M, Coupier J, Girard ML, Bousser J, Bilskipasquier G (1970) Dysfibrinogénémie acquise dans les atteintes hépatiques sévères. Coagulation 3:37–44

    CAS  Google Scholar 

  • Stein SF, Harker LA (1982) Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis. J Lab Clin Med 99: 217–230

    PubMed  CAS  Google Scholar 

  • Warren L (1959) The thiobarbituric acid assay of sialic acids. J Biol Chem 234:1971–1975

    PubMed  CAS  Google Scholar 

  • Winkelmann M, Schneider W, Schmitz G, Aul C, Scharf RE, Pfitzer P (1983) Reifestadienverteilung und Polyploidiemuster der Megakaryozyten bei Patienten mit Leberzirrhose. Verh Dtsch Ges Inn Med 89 (im Druck)

    Google Scholar 

Literatur

  1. Braine HG, Sensenbrenner LL, Wright SK, Tuschka PJ, Sarai R, Santos GW (1982) Bone marrow transplantation with major ABO blood group incompatibility using erythrocyte depletion of marrow prior to infusion. Blood 60:420–425

    PubMed  CAS  Google Scholar 

  2. Camitta BM, Thomas ED, Nathan DG, Santos GW, Gordon-Smith EC (1975) Severe aplastic anemia: An indication for marrow transplantation. Blood 46:1001–1007

    Google Scholar 

  3. Cline MJ, Gale RP, Stiehm ER, Opelz G, Lowell SY, Feig SA, Fahey JL (1975) Bone marrow transplantation in man. Ann Intern Med 83: 691–701

    PubMed  CAS  Google Scholar 

  4. Hinterberger W, Schmidmeier W, Höcker P, Neumann E, Lechner K (1982) Prognostic significance of the number of myeloid committed stem cells (CFUc-GM) in the bone marrow and blood of patients with aplastic anemia. Exp Haematol (in press)

    Google Scholar 

  5. Kersey JH (1983) Prevention of graft versus host disease. J Cell Biochem (Suppl) 7A: 116 (Abstract)

    Google Scholar 

  6. Lynch RE, Williams DM, Reading JC, Cartwright GD (1975) The prognosis in aplastic anemia. Blood 45:517–525

    PubMed  CAS  Google Scholar 

  7. Pike BI, Robinson WA (1970) Human bone marrow colony growth in agar-gel. J Cell Physiol 76: 77–84

    Article  PubMed  CAS  Google Scholar 

  8. Storb R, Doney K, Thomas ED, Appelbaum F, Buckner CD, Clift RA, Deeg J, Goodall BW, Hackman R, Hansen JA, Sanders JA, Sullivan KM, Weiden PL, Witherspoon RP (1982) Transplantation with or without donor buffy coat cells for 65 transfused aplastic anemia patients. Blood 59: 236–243

    PubMed  CAS  Google Scholar 

  9. Storb R, Prentice RL, Thomas ED (1977) Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. N Engl J Med 296: 61–66

    Article  PubMed  CAS  Google Scholar 

  10. Storb R, Thomas ED, Buckner CD, Clift RA, Deeg HJ, Fefer A, Goodall BW, Sale GE, Sanders JA, Singer J, Stewart P, Weiden PL (1980) Marrow transplantation in thirty untransfused patients with severe aplastic anemia. Ann Intern Med 92:30–38

    PubMed  CAS  Google Scholar 

Literatur

  • Camitta BM, Thomas ED, Nathan DG, Gale RP, Kopecky KJ, Rappeport JM, Santos G, Gordon-Smith EC, Storb R (1979) A prospective study of androgens and bone marrow transplantations for treatment of severe aplastic anaemia. Blood 53: 504–514

    PubMed  CAS  Google Scholar 

  • Ramsay NKC, Kim T, Nesbit ME, Krivit W, Coccia PF, Levitt SH, Woods WG, Kersey JH (1980) Total lymphoid irradition and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia. Blood 55: 344–346

    PubMed  CAS  Google Scholar 

  • Schmeiser T, Arnold R, Kurrle E, Kubanek B, Pflieger H, Heimpel H, Krieger D (1983) Infection prophylaxis in bone marrow transplantation with two different methods of gnotobiotic care. Exp Hematol (in press)

    Google Scholar 

  • Storb R, Thomas ED, Weiden PL, Buckner CD, Clift RA, Fefer A, Goodell BW, Johnson FL, Neiman PE, Sanders JE, Singer J (1978) One-hundred-ten patients with aplastic anemia (AA) treated by bone marrow transplantation in Seattle. Transplant Proc 10:135–140

    PubMed  CAS  Google Scholar 

  • Storb R, Thomas ED, Buckner CD, Clift RA, Deeg J, Fefer A, Goodell BW, Sale GE, Sanders JE, Singer J, Stewart P, Weiden PL (1980) Marrow transplantation in thirty “untransfused” patients with severe aplastic anemia. Ann Intern Med 92:30–36

    PubMed  CAS  Google Scholar 

Literatur

  1. Alexanian R, Balcerzak S, Bonnet JD, Gehan EA, Haut A, Hewlett JS, Monto RW (1975) Prognostic factors in multiple myeloma. Cancer 36: 1192–1201

    Article  PubMed  CAS  Google Scholar 

  2. Bayrd ED (1948) The bone marrow on sternal aspiration in multiple myeloma. Blood 3: 987–1018

    PubMed  CAS  Google Scholar 

  3. Bergsagel D (1976) Annotation: The treatment of plasma cell myeloma. Br J Haematol 33: 443–449

    Article  PubMed  CAS  Google Scholar 

  4. Cox DR (1972) Regression models and life-tables (with discussion). J R Stat Soc [B] 34:187–220

    Google Scholar 

  5. Durie BGM, Salmon SE (1975) A clinical staging system for multiple myeloma. Cancer 36: 842–854

    Article  PubMed  CAS  Google Scholar 

  6. Ludwig H (1982) Multiples Myelom. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  7. Matzner Y, Benbassat J, Polliack A (1978) Prognostic factors in multiple myeloma. Acta Haematol (Basel) 60:257–268

    Article  CAS  Google Scholar 

  8. Merlini G, Waldenström JG, Jayakar SD (1980) A new improved clinical staging system for multiple myeloma based on analysis of 123 treated patients. Blood 55:1011–1018

    PubMed  CAS  Google Scholar 

  9. Non-Hodgkin’s Lymphoma Pathologic Classification Project (1982) National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas. Cancer 49: 2112–2135

    Google Scholar 

  10. Vercelli D, Di Guglielmo R, Guidi G, Scolari L, Buricchi L, Cozzolino F (1980) Bone marrow percentage of plasma cells in the staging of monoclonal gammopathies. Nouv Rev Fr Hematol Blood Cells 22: 139–145

    CAS  Google Scholar 

  11. Wutke K, Rüdiger KD, Kelényi G (1979) Prognoserelevante klinische und morphologische Klassifikation des multiplen Myeloms. Arch Geschwulstforsch 49: 671–684

    PubMed  CAS  Google Scholar 

Literatur

  1. Fourth International Workshop on Chromosomes in Leukemia (1982) Cancer Genet Cytogenet (in press)

    Google Scholar 

  2. Third International Workshop in Chromosomes in Leukemia, 1980 (1981): Chromosomal abnormalities in acute lymphoblastic leukemia: structural and numerical changes in 234 cases. Cancer Genet Cytogenet 4:101–110

    Google Scholar 

  3. Third International Workshop on Chromosomes in Leukemia, 1980 (1981): Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Genet Cytogenet 4:111–137

    Google Scholar 

  4. Esseltine DW, Vekemans M, Seemayer T, Reece E, Gordon J, Whitehead VM (1982) Significance of a (4; 11) translocation in acute lymphoblastic leukemia. Cancer 50: 503–506

    Article  PubMed  CAS  Google Scholar 

  5. Morse HG, Heideman R, Hays T, Robinson A (1982) 4; 11 translocation in acute lymphoblastic leukemia: a specific syndrome. Cancer Genet Cytogenet 7:165–172

    Article  PubMed  CAS  Google Scholar 

  6. Oshimura M, Freeman A, Sandberg AA (1977) Chromosomes and causation of human cancer and leukemia. XXVI. Banding studies in acute lymphoblastic leukemia (ALL). Cancer 40:1161–1172

    Article  PubMed  CAS  Google Scholar 

  7. Parkin JL, Arthur DC, Abramson CS, McKenna RW, Kersey JH, Heideman RL, Brunning RD (1982) Acute leukemia associated with the t (4; 11) chromosome rearrangement: ultrastructural and immunologic charakte-ristics. Blood 60:1321–1331

    PubMed  CAS  Google Scholar 

  8. Prigogina EL, Fleischman EW, Puchkova GP, Kulagina OE, Majakova SA, Balakirev SA, Frenkel MA, Khvatova NV, Peterson IS (1979) Chromosomes in acute leukemia. Hum Genet 53: 5–16

    Article  PubMed  CAS  Google Scholar 

  9. Van den Berghe H, David G, Broeckaert-van Orshoven A, Louwagie A, Verwilghen R, Casteels-Van Deele M, Eggermont E, Eeckels R (1979) A new chromosome anomaly in acute lymphoblastic leukemia (ALL). Hum Genet 46:173–180

    Article  PubMed  Google Scholar 

Literatur

  1. Benöhr H, Reu G, Wilms K, Waller HD (1980) Langjährige Überlebenszeit bei Erwachsenen mit akuter Leukämie. Blut 40: 399–406

    Article  PubMed  Google Scholar 

  2. Gerecke D, Hirschmann WD, Voigtmann R, Gross R (1979) Remission induction and remission maintenance in adult acute non-lymphocytic leukemia employing a modified cytostatic (COAP) regimen. Blut 39: 39–45

    Article  PubMed  CAS  Google Scholar 

  3. Gerecke, D, Kreß M, Hirschmann WD (1983) Long term follow-up of remission patients in adult acute leukemia. Klin Wochenschr (im Druck)

    Google Scholar 

Literatur

  1. Crowther D (1981) New approaches to the management of patients with Non-Hodgkin’s lymphoma of high grade pathology. Br J Cancer 43:417–435

    Article  PubMed  CAS  Google Scholar 

  2. Jones SE, Miller T (1982) Chemotherapy of malignant lymphomas of unforable histology. In: Rosenberg SA, Kaplan HJ (eds) Malignant lymphomas. Academic Press

    Google Scholar 

  3. McKelvey E, Gottlieb J, Wilson E et al. (1976) Hydroxyldaunomycin (Adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38:1484–1493

    Article  PubMed  CAS  Google Scholar 

  4. De Vita VT, Mubbard SM (1982) The curative potential of chemotherapy in the treatment of Hodgkin’s disease and Non-Hodgkin’s lymphomas. In: Rosenberg SA, Kaplan HJ (eds) Malignant lymphomas. Academic Press

    Google Scholar 

Literatur

  1. Wördehoff D (1981) Diagnostischer Wert laborchemischer Ascitesuntersuchungen. Leber Magen Darm 1:25–30

    Google Scholar 

  2. Storey D et al. (1976) Pleural effusion. JAMA 236:2183–2185

    Article  PubMed  CAS  Google Scholar 

  3. Ali IU, Hunter T (1981) Structural comparison of fibronectins from normal and transformed cells. J Biol Chem 25:7671–7677

    Google Scholar 

Literatur

  1. McMichael AJ, Potter JD (1980) Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. J Natl Cancer Inst 65:1201–1207

    PubMed  CAS  Google Scholar 

  2. Stedman KE, Moore GE, Morgan RT (1980) Estrogen receptor proteins in diverse human tumors. Arch Surg 115: 244–248

    Article  PubMed  CAS  Google Scholar 

  3. Bojar H, Stuhldreier B, Becher R, Koldorsky V, Goerz G, Merk H, Staib W (1982) Gradient centrifugation analysis of steroid-hormone binding in human malignant melanoma. Anticancer Res 2: 245–250

    PubMed  CAS  Google Scholar 

  4. Kiang DT, Dennedy BJ (1977) Estrogen receptor assay in the differential diagnosis of adenocarcinomas. JAMA 238: 32–34

    Article  PubMed  CAS  Google Scholar 

  5. McClendon JE, Appleby D, Clandon DB, Donegan WL, De Cosse JJ (1977) Colonic neoplasms: tissue estrogen receptor and carcinoembryonic antigen. Arch Surg 112: 240–241

    Article  PubMed  CAS  Google Scholar 

  6. Alford TC, Do H-M, Geelhoed GW, Tsangaris NT, Lippman ME (1979) Steroid hormone receptors in human colon cancers. Cancer 43:980–984

    Article  PubMed  CAS  Google Scholar 

  7. Carson E, Antuoro L, Brockmeyer D, Critselis AN (1980) Estrogen and progesterone receptors in colon carcinoma (preliminary report). Clin Res 28: 682A

    Google Scholar 

  8. Leake RE, Laing L, Calman KC, Macbeth FR (1980) Estrogen receptors and antiestrogen therapy in selected human solid tumors. Cancer Treat Rep 64:797–799

    PubMed  CAS  Google Scholar 

  9. Maillot KV, Hermanek P, Gentsch HH, Ober KG (1980) Steroid receptors in malignant tumors of male patients. In: Wittlift JL, Dapunt O (eds) Steroid receptors and hormone-dependent neoplasia. Masson Publ., New York, pp 215–218

    Google Scholar 

  10. Sica V, Contièri E, Nola E, Bova R, Papaleo G, Puca GA (1981) Estrogen and progesterone binding proteines in human colorectal cancer. A preliminary characterization of estradiol receptor. Tumori 67:307–314

    PubMed  CAS  Google Scholar 

  11. Panettiere FJ, Timothy T, Rogers C (1982) SWOG trial of tamoxifen in patients with advanced colorectal adenocarcinoma. Proc Am Soc Clin Oncol 23 : C-364

    Google Scholar 

Literatur

  1. Asseo PP, Tracopoulos GD (1982) Simultaneous enzyme immunoassay of CEA in pleural effusion and serum. Am Soc Clin Pathol 77: 66–71

    CAS  Google Scholar 

  2. Blair OM, Goldenberg DM (1974) A correlative study of bronchial cytology, bronchial washing CEA, and plasma CEA in the diagnosis of bronchogenic cancer. Acta Cytol (Baltimore) 18: 510–514

    CAS  Google Scholar 

  3. Gold P, Freedman SO (1965) Demonstration of tumor specific antigens in human colonic carcinomata by immunologic tolerance an absorption techniques. J Exp Med 121: 439–462

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Hansen M, Hummer M (1979) Ectopic hormone production in small cell carcinoma. In: Muggia F, Rosenzweig M (eds) Lung cancer progress in therapeutic research. Raven Press, New York, pp 199–207

    Google Scholar 

  2. Luster W, Gropp C, Sostmann H, Kalbfleisch H, Havemann K (1982) Demonstration of immunoreactive calcitonin in sera and tissues of lung cancer patients. Eur J Cancer Clin Oncol 18:1275–1283

    Article  PubMed  CAS  Google Scholar 

  3. Gropp C, Havemann K, Kalbfleisch H, Luster W, Sostmann H (1982) Antidiuretisches Hormon bei Patienten mit Bronchialkarzinom. Dtsch Med Wochenschr 107: 974–977

    Article  PubMed  CAS  Google Scholar 

  4. Gropp C, Havemann K, Scheuer A (1980) Ectopic hormones in lung cancer patients at diagnosis and during therapy. Cancer 46: 347–354

    Article  PubMed  CAS  Google Scholar 

  5. Havemann K, Gropp C, Scheuer A, Scherfe T, Gramse M (1979) ACTH-like activity in immune complexes of patients with oatcell carcinoma of the lung. Br J Cancer 39:43–50

    Article  PubMed  CAS  Google Scholar 

  6. Goldstein IJ, Hollermann CE, Smith EE (1965) Proteincarbohydrate interaction. II. Inhibition studies on the interaction of concavalin A with polysaccharides. Biochemistry 4: 876–883

    Article  PubMed  CAS  Google Scholar 

  7. Gazdar AF, Carney DN, Guccion IG, Baylin SB (1981) Small cell carcinoma of the lung: cellular origin and relationship to other pulmonary tumors. In: Greco FA, Oldham RK, Bunn PA (eds) Small cell lung cancer. Grune and Stratton, New York, pp 145–176

    Google Scholar 

  8. Nakanishi S, Inoue A, Kita T, Nakamura M, Chany ACY, Cohen SN, Numa S (1979) Nucleotide sequence of cloned cDNA for bovine corticitropin-β-lipotropin precursor. Nature 278: 423–427

    Article  PubMed  CAS  Google Scholar 

  9. Mains RE, Eipper BA, Ling N (1977) Common precursor to corticotropins and endorphins. Proc Natl Acad Sci USA 74:3014–3018

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Hehlmann R, Baumgarten A, Schreiber MA, Schetters H, Luz A, Mesa-Tejada R, Lohe KJ, Prechtel K (1981) Kreuzreaktion menschlicher Mammakarzinome mit dem Hüllglykoprotein gp52 des Mausmam-matumorvirus (MMTV). Verh Dtsch Ges Pathol 65:275–279

    PubMed  CAS  Google Scholar 

  • Hehlmann R, Baumgarten A, Schreiber MA, Schetters H, Luz A, Mesa-Tejada R, Lohe KJ, Prechtel K (1982) Crossreaction of antigens in sections of human breast cancers with the envelope glycoprotein gp52 of the mouse mammary tumor virus: a marker for human mammary carcinoma— Eur J Cancer Clin Oncol 18:1399

    Google Scholar 

  • Keydar I, Chen L, Karby S, Weiss FR, Delarea J, Radu M, Chaitcik S, Brenner HJ (1979) Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer 15: 659–670

    PubMed  CAS  Google Scholar 

  • Mesa-Tejada R, Keydar I, Ramanarayanan M, OhnoT, Fenoglio C, Spiegelman S (1978) The detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of the mouse mammary tumor virus. Proc Natl Acad Sci USA 75:1529–1533

    Article  PubMed  CAS  Google Scholar 

  • Mesa-Tejada R, Oster MW, Fenoglio CM, Magidson J, Spiegelman S (1982) Diagnosis of primary breast carcinoma through immunohistochemical detection of mouse mammary tumor virus-related antigen in metastatic lesions. A report of two cases. Cancer 49:261–268

    Article  PubMed  CAS  Google Scholar 

  • Ohno T, Mesa-Tejada R, Keydar I, Ramanarayanan M, Bausch J, Spiegelman S (1979) The human breast carcinoma antigen is immunologically related to the polypeptide of the group-specific glyoprotein of the mouse mammary tumor virus. Proc Nat Acad Sci USA 76:2460–2464

    Article  PubMed  CAS  Google Scholar 

  • Prechtel K, Schmidt H, Gehm O (1982) Langzeitbeobachtung von Frauen mit bioptisch gesicherten Mastopathien unterschiedlicher Schwe-regrade. In: Bohmert H (Hrsg) Brustkrebs und Brustrekonstruktion. Thieme, Stuttgart: 58–61

    Google Scholar 

  • Spiegelman S, Keydar I, Mesa-Tejada, R, Ohno T, Ramanarayanan M, Nayak R, Bausch J, Fenoglio C (1980) Possible diagnostic implications of a mammary tumor virus related protein in human breast cancer. Cancer 46:879–892

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Bleyer WA (1978) The clinical pharmacology of methotrexate. Cancer 41: 36–51

    Article  PubMed  CAS  Google Scholar 

  2. Djerassi I et al. (1972) Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer. Cancer 30: 22–30

    Article  PubMed  CAS  Google Scholar 

  3. Jaffe N et al. (1974) Adjuvant methotrexate and citrovorum factor treatment of osteogenic sarcoma. N Engl J Med 291:994–997

    Article  PubMed  CAS  Google Scholar 

  4. Methotrexate (125J) radioimmunoassay kit instruction manual. Diagnostic Biochemistry Inc., San Diego, California, 1978

    Google Scholar 

  5. Rosen G et al. (1980) Response of primary osteogenic sarcoma to single agent therapy with high-dose methotrexate with citrovorum factor rescue. Proc. 11th ICC and 19th ICAAC

    Google Scholar 

  6. Sauer H, Schalhorn A (1980) Rationale Grundlagen und Praxis des Citrovorumfaktor(Leucovorin)-Schutzes nach hochdosierter Methotrexat-Therapie. Onkologie 3: 64–71

    Article  PubMed  CAS  Google Scholar 

  7. Schalhorn A et al. (1980) Methotrexat-Nachweis im menschlichen Serum — Vergleich zwischen einer enzymatischen und einer enzymimmunologischen Methode. Onkologie 4:193–196

    Article  Google Scholar 

  8. Schalhorn A et al. (1982) Pharmacokinetics of erythrocyte methotrexate after high-dose methotrexate. Cancer Chemother Pharmacol 9: 65–69

    Article  PubMed  CAS  Google Scholar 

  9. Schalhorn A et al. (1983) Methotrexate and methotrexate polyglutamate in human sarcoma metastases after high-dose methotrexate therapy, (eingereicht zur Publikation)

    Google Scholar 

  10. Wilmanns W, Martin H (1968) Wirkung und Verteilung von Methotrexat im menschlichen Organismus bei der Leukämiebehandlung. Klin Wochenschr 46: 281–296

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Fiebig HH, Henß H, Schuchhardt C, Löhr GW (1982) Xenotransplantation und Chemotherapie menschlicher Tumoren, Vergleich des Ansprechens der Malignome beim Patienten und in der Nacktmaus. Verh Dtsch Ges Inn Med 88: 966–969

    Google Scholar 

  • Fiebig HH, von Kleist S (1982) Carcinoembryonic antigen (CEA) in human colorectal cancers growing subcutaneously in nude mice. J Cancer Res Clin Oncol (in press)

    Google Scholar 

  • Pantelouris EM (1968) Absence of the thymus in a mouse mutant. Nature 217:370

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Hamburger A, Salmon SE (1977) Primary bioassay on human tumor stem cells. Science 197: 461–463

    Article  PubMed  CAS  Google Scholar 

  2. von Hoff DD, Caspar J, Bradley E, Sandbach J, Jones D, Makuch R (1981) Association between human tumor colony-forming assay results and response of an individual patient’s tumor to chemotherapy. Am J Med 70:1027–1032

    Article  Google Scholar 

  3. Nelson RL, Dyke RW, Root MA (1980) Comparative pharmacokinetics of Vindesine, Vincristine and Vinblastine in patients with cancer. Cancer Treat Rev 7: 17–24

    Article  PubMed  Google Scholar 

  4. Salmon SE, Hamburger AW, Soehnlen B, Durie BGM, Alberts DS, Moon TE (1978) Quantitation of differential sensitivity of human tumor stem cells to anticancer drugs. N Engl J Med 298: 1321–1327

    Article  PubMed  CAS  Google Scholar 

  5. Stephenson JR, Axelrad AA, McLeod DL, Shreeve MM (1971) Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc Natl Acad Sci USA 68:1542;1546

    Article  Google Scholar 

Literatur

  1. Kennedy PS, Luedke DW (1979) Adenocarcinoma of unknown origin. A rational approach to a diagnostic puzzle. Postgrad Med 65:151

    PubMed  CAS  Google Scholar 

  2. Nissenblatt MG (1981) The CUP syndrome (carcinoma unknown primary). Cancer Treat Rev 8:211

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Hegemann G, Mühe E (1976) Exstirpation von Metastasen. Langenbecks Arch Chir 342:261

    Article  PubMed  CAS  Google Scholar 

  2. Fischer J, Weigand H, Preiß J (1983) Regionale Chemotherapie von Lebermetastasen. In: Fischer J (Hrsg) Taschenbuch der Onkologie. Urban u. Schwarzenberg, S 118 ff

    Google Scholar 

  3. Chen H-SG, Gross JF Intra arterial infusion of anticancer drugs: Theoretic aspects of drug delivery and review of responses

    Google Scholar 

  4. Jaffe BM, Donegan WL, Watson F (1968) An investigation of the factors which influence the survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 127:1

    PubMed  CAS  Google Scholar 

Literatur

  1. Bruntsch U, Gallmeier WM (1980) Schmerztherapie im fortgeschrittenen Krebsstadium. Münch Med Wochenschr 122: 7–9

    CAS  Google Scholar 

  2. Catalano RB (1975) The medical approach to management of pain caused by cancer. Semin Oncol 2: 379–392

    PubMed  CAS  Google Scholar 

  3. Melzack R, Mount BM, Gordon JM (1979) The Brompton mixture versus morphine solention given orally: effects on pain. Can Med Assoc J 120: 435–438

    PubMed  CAS  Google Scholar 

  4. Moertel CG, Ahmann DL, Taylor WF, Schwartau N (1972) A comparative evaluation of marketed analgesic drugs. N Engl J Med 286: 813–815

    Article  PubMed  CAS  Google Scholar 

  5. Moertel CG, Ahmann DL, Taylor WF, Schwartau N (1974) A controlled evaluation of analgesic combinations. JAMA 229: 55–59

    Article  PubMed  CAS  Google Scholar 

  6. Schlegel G (1982) Die Therapie des Tumorschmerzes. Tumor Diagnostik 3:10–16

    Google Scholar 

  7. Schreml W, Merkle W, Heimpel H (1981) Medikamentöse Schmerztherapie bei Krebspatienten. Med Klin 76:43–47

    PubMed  CAS  Google Scholar 

  8. Senn HJ, Glaus A (1982) Schmerz und Schmerzbekämpfung bei Tumorleiden. Schweiz Med Wochenschr 112:1158–1164

    PubMed  CAS  Google Scholar 

  9. Twycross RG (1974) Clinical experience with diamorphine in advanced malignant disease. Int J Clin Pharmacol Biopharm 9:184–198

    Google Scholar 

  10. Twycross RG (1977) Choice of analgesics in terminal cancer. Practitioner 219:475–478

    PubMed  CAS  Google Scholar 

Literatur

  • Carcassone M (1982) Les.effets de l’alizapride dans les vomissements chez le nourrisson et l’enfant. Sem Hop Paris 58: 357–361

    Google Scholar 

  • Casanova P, Girard D (1982) Etude comparative alizapride-metopimazine. Sem Hop Paris 58:345–348

    PubMed  CAS  Google Scholar 

  • Girard D, Salles E, Bel A (1982) Etude des effets d’un nouneau benzamide, l’alizapride, dans les nausees et les vomissements en medicine interne. Sem Hop Paris 58: 353–358

    PubMed  CAS  Google Scholar 

  • Gralla JG, Loretta MI, Pisco SE, Squillante AE, Kelsen DP, Braun DW, Bordin LA, Braun TJ, Young CW (1981) Antimetic effica-cy of high dose metoclopramide: Randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vometing. N Engl J Med 305: 905–909

    Article  PubMed  CAS  Google Scholar 

  • Houin G, Bree F, Tillement JP (1982) Pharmacocinetique et biodisponibilite de l’alizapride chez l’homme. Sem Hop Paris 58:339–344

    PubMed  CAS  Google Scholar 

Literatur

  1. Balkwill FR (1979) Interferons as cell-regulatory molecules. Cancer Immunol Immunother 7: 7–14

    Article  CAS  Google Scholar 

  2. Evinger M, Maeda S, Pestka S (1981) Recombinant human leukocyte interferon produced in bacteria has antiproliferative activity. J Biol Chem 256:2113–2114

    PubMed  CAS  Google Scholar 

  3. Gutterman JU, Blumenschein GR, Alexanian R, Yap H-Y, Buzdar AU, Cabanillas F, Hortobagyi GN, Hersh EM, Rasmussen SL, Harmon M, Kramer M, Pestka S (1980) Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann Intern Med 93: 399–406

    PubMed  CAS  Google Scholar 

  4. Herberman RB, Djeu JY, Ortaldo JR, Holden HT, West WH, Bonnard GD (1978) Role of interferon in augmentation of natural and antibody-dependent cell-mediated cytotoxicity. Cancer Treat Rep 62: 1893–1896

    PubMed  CAS  Google Scholar 

  5. Maeda S, McCandliss R, Gross M, Sloma A, Familletti PC, Tabor JM, Evinger M, Levy WP, Pestka S (1980) Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Proc Natl Acad Sci USA 77: 7010–7013

    Article  PubMed  CAS  Google Scholar 

  6. Mellstedt H, Björkhom M, Johansson B, Ahre A, Holm G, Strander H (1979) Interferon therapy in myelomatosis. Lancet 1: 245–247

    Article  PubMed  CAS  Google Scholar 

  7. Merigan TC, Sikora K, Breeden JH, Levy R, Rosenberg SA (1978) Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin’s lymphoma. N Engl J Med 299:1449–1453

    Article  PubMed  CAS  Google Scholar 

  8. Miller AB, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47:207–214

    Article  PubMed  CAS  Google Scholar 

  9. Priestman TJ (1979) Interferon: an anti-cancer agent? Cancer Treat Rev 6: 223–237

    Article  PubMed  CAS  Google Scholar 

  10. Sherwin SA, Knost JA, Fein S, Abrams PG, Foon KA, Ochs JJ, Schoenberger C, Maluish AE, Oldham RK (1982) A multiple-dose phase I trial of recombinant leukocyte A interferon in cancer patients. JAMA 248:2461–2466

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. MacDonald JS, Boiron M, Brunet R, Gisselbrecht C, Lagarde C, Schein PS, Woolley PV (1979) FAM combination chemotherapy results in 61 patients with advanced gastric cancer. Proc Am Assoc Cancer Res/ASCO 20:C-434

    Google Scholar 

  2. Queißer W, Schnitzler G, Schäfer J, Arnold H, Drings P, Fritze D, Geldmacher J, Hartwich G, Herrmann R, Kempf P, König H, Meiser RJ, Nedden R, von Oldershausen H-F, Pappas A, Sievers H, Wahrendorf J, Westerhausen M, Witte S (1981) Comparison of ftorafur with 5-fluorouracil in combination chemotherapy of advanced gastrointestinal carcinoma. Recent Results Cancer Res 79:82

    Article  PubMed  Google Scholar 

Literatur

  1. Dekker AW, Rozenberg-Arska M, Sixma JJ, Verhoef J (1981) Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. Ann Intern Med 95: 555–559

    PubMed  CAS  Google Scholar 

  2. Gurwith MJ, Brunton JL, Lank BA, Harding GKM, Ronald AR (1979) A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. Am J Med 66: 248–256

    Article  PubMed  CAS  Google Scholar 

  3. Hughes WT, Kuhn S, Chaudhary S, Feldman S, Verzosa M, Aur RJA, Pratt C, George SL (1977) Succesful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med 297:1419–1426

    Article  PubMed  CAS  Google Scholar 

  4. Krieger D, Vanek E, Strehle R (1981) Influence of total and selective decontamination on the aerobic and anaerobic gastrointestinal flora in patients with acute leukaemia. In: Sasaki S, Ozawa A, Hashimoto K (eds) Recent advances in germfree research. Tokai University Press, Tokyo, pp 715–718

    Google Scholar 

  5. Kurrle E (1981) Infektprophylaxe bei der Induktionstherapie akuter Leukämien. Klin Wochenschr 59:1075–1079

    Article  PubMed  CAS  Google Scholar 

  6. Sleijfer DT, Mulder NH, de Vries-Hospers HG, Fidler V, Nieweg HO, van der Waaij D, van Saene HKF (1980) Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer 16: 859–869

    PubMed  CAS  Google Scholar 

  7. Van der Waaij D (1979) The colonization resistance of the digestive tract in man and animals. Zentralbl Bakteriol (Suppl) 7: 155–161

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 J. F. Bergmann Verlag, München

About this paper

Cite this paper

Bodemann, H.H. et al. (1983). Hämatologie/Onkologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85456-9_19

  • Publisher Name: J.F. Bergmann-Verlag

  • Print ISBN: 978-3-8070-0335-1

  • Online ISBN: 978-3-642-85456-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics