Zusammenfassung
Die chronisch aktive Hepatitis (CAH) ist ein ätiologisch heterogenes Krankheitsbild. Autoantikörper gegen ein mikrosomales Antigen aus Leber und Niere (LKM) scheinen eine Subgruppe der CAH zu charakterisieren (Rizetto et al. 1973, 1974) [1, 2]. In der bisher angewendeten Immunfluoreszenztechnik (IF) an Nierenschnitten können diese Antikörper nur sehr schwer von antimitochondrialen (AMA) und anderen zytoplasmatischen Antikörpern unterschieden werden. Es ist bisher nicht geklärt, ob bei der primär biliären Zirrhose (PBC) zusätzlich zu AMA LKM-Antikörper vorkommen. Mit der Immunfluoreszenz kann ein zusätzliches Auftreten von LKM-Antikörpern nicht differenziert werden. Außerdem stand bisher ein spezifisches serologisches Testsystem nicht zur Verfügung.
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© 1983 J. F. Bergmann Verlag, München
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Manns, M. et al. (1983). Hepatologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_16
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