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Antibakterielle Abwehrmechanismen

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Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 85))

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Zusammenfassung

Die erfolgreiche Abwehr von Infektionen durch Mikroorganismen hängt von Resistenz und Immunität ab. Resistenz ist nicht antigenspezifisch; sie wird in ihrer Ausprägung durch genetische Faktoren und umweltbedingte Einflüsse wie Ernährung, Überanstren-gung und Krankheit bestimmt. Hingegen bedeutet Immunität die Abwehrleistung, welche auf dem Vorhandensein von Prodiikten des Immunsystems beruht. Immunität ist er-worben, da sie erst nach Kontakt mit Antigenen des Mikroorganismus entsteht und im Gegensatz zur Resistenz spezifisch ist.

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Literatur

  1. Metschnikow, E.: Leçons sur la pathologie comparée l’inflammation. Paris, 1892.

    Google Scholar 

  2. van Furth, R. (ed.): Mononuclear phagocytes. Oxford, Edinburgh: Blackwell Scientific Publications 1970.

    Google Scholar 

  3. Bainton, D. F.: Differentiation of human neutrophilic granulocytes: Normal and abnormal. In: The granulocyte: Function and clinical utilization. Greenwalt, T. J., Jamieson, G. A. (eds.), pp. 1–27. New York: Alan Liss Inc. 1977.

    Google Scholar 

  4. Baggiolini, M., de Duve, C, Masson, P. L.: Association of lactoferrin with specific granules in rabbit heterophil leukocytes. J. Exp. Med. 131, 559–570 (1970).

    Article  PubMed  CAS  Google Scholar 

  5. Baggiolini, M., Hirsch, J. G., de Duve, C: Resolution of granules from rabbit heterophil leukocytes into distinct populations by zonal sedimentation. J. Cell Biol. 40, 529 (1969).

    Article  PubMed  CAS  Google Scholar 

  6. Cartwright, G. E., Athens, J. W., Wintrobe, M. D.: The ki­netics of granulopoesis in man. Blood 24, 780–803 (1964).

    PubMed  CAS  Google Scholar 

  7. Wilkinson, P. C: The role of chemotaxis in inflammatory reactions. In: Chemotaxis and inflammation, pp. 148–166. London: Churchill Livingstone 1974.

    Google Scholar 

  8. Ward, P. A., Becker, E. L.: Biology of leukotaxis. Rev. Physiol. Biochem. Pharmacol. 77, 125–148 (1977).

    Article  PubMed  CAS  Google Scholar 

  9. Stossel, T. P.: The mechanism of leukocyte locomotion. In: Leukocyte chemotaxis. Gallin, J. I., Quie, P. G. (eds.), pp. 143–160. New York: Raven Press.

    Google Scholar 

  10. Huber, H., Weiner, H.: Binding of immune complexes to human macrophages: The role of membrane receptor sites. In: Activation of mac­rophages. Wagner, W.-H., Hahn, H. (eds.), pp. 54–62. Amsterdam, New York: Excerpta Medica/Ameri-can Elsevier 1974.

    Google Scholar 

  11. Wellek, B., Hahn, H., Opferkuch, W.: Quantitative contributions of IgG, IgM, and C3 to erythrophagocytosis and rosette formation by peritoneal macrophages, and anti-opsonin activity of dextran sulfate 500. Eur. J. Immunol. 5, 378–381 (1975).

    Article  Google Scholar 

  12. Hirsch, J. G.: Cinematographic ob­servations on granule lysis in polymorphonuclear leukocytes during phagocytosis. J. Exp. Med. 116, 827 (1962).

    Article  PubMed  CAS  Google Scholar 

  13. Stossel, T. P., Hartwig, J. H.: Interaction of actin, myosin and a new actin-binding protein of rabbit pulmonary macrophages. J. Cell Biol. 68, 602–619 (1976).

    Article  PubMed  CAS  Google Scholar 

  14. Bainton, D. F.: Sequential degranu-lation of the two types of polymorphonuclear leukocyte granules during phagocytosis of microorganisms. J. Cell Biol. 58, 249–264 (1973).

    Article  PubMed  CAS  Google Scholar 

  15. Stossel, T. P., Pollard, T. D., Mason, R. J.: Isolation and properties of phagocytic vesicles from polymorphonuclear leukocytes. J. Clin. Invest. 50, 1745–1757 (1971).

    Article  PubMed  CAS  Google Scholar 

  16. Babior, B. M.: Oxygen-dependent microbial killing by phagocytes. N. Engl. J. Med. 298, 659–668, 721–725 (1978).

    Article  PubMed  CAS  Google Scholar 

  17. de Chatelet, L. R.: Initiation of respiratory burst in human polymorphonuclear neutrophils: a critical review. J. Reticuloendothel. Soc. 24, 73–91 (1978).

    Google Scholar 

  18. Bainton, D. F., Farquhar, M. G.: Difference in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. II. Cytochemistry and electron microscopy of bone marrow cells. J. Cell Biol. 39, 299–317 (1968).

    Article  PubMed  CAS  Google Scholar 

  19. Har­rison, J E, Schultz, J.: Studies on the chlorinating activity of myeloperoxidase. J. Biol. Chem. 251, 1371–1374 (1976).

    Google Scholar 

  20. Klebanoff, S. J.: Iodination of bacteria: a bactericidal mechanism. J. Exp. Med. 126, 1063–1078 (1967).

    Article  PubMed  CAS  Google Scholar 

  21. Beauchamp, C, Fridovich, I.: A mechanism for the production of ethylene from methional: the generation of hydroxyl radical by xanthine oxidase. J. Biol. Chem. 245, 4641–4646 (1970).

    PubMed  CAS  Google Scholar 

  22. Klebanoff, S. J.: Antimicrobial systems of the polymorphonuclear leukocyte. In: The phago­cytic cell in host resistance. Bellanti, J. A., Dayton, D. H. (eds.), pp. 45–60. New York: Raven Press 1975.

    Google Scholar 

  23. Rosen, H., Klebanoff, S. J.: Formation of singlet oxygen by the myeloperoxidase-mediated an­timicrobial system. J. Biol. Chem. 252, 4803–4810(1977).

    PubMed  CAS  Google Scholar 

  24. McCord, J. M., Fridovich, I.: The biology and pathology of oxygen radicals. Ann. Intern. Med. 89, 122–127 (1978).

    PubMed  CAS  Google Scholar 

  25. Spitznagel, J. K.: Bacterici­dal mechanisms of the granulocyte. In: The granulocyte: Function and clinical utilization. Greenwalt, T. J., Jamieson, G. A. (eds.), pp. 103–139. New York: Alan Liss Inc. 1977.

    Google Scholar 

  26. Mandell, G. L.: Intra-phagosomal pH of human polymorphonuclear neutrophils. Proc. Soc. Exp. Biol. Med. 447–449 (1970).

    Google Scholar 

  27. Strominger, J. L., Tipper, D. J.: Structure of bacterial cell walls: the lysozyme substrate. In: Lysozy-me. Osserman, E. F., Canfield, R. E., Beychok, S. (eds.), pp. 169–184. New York: Academic Press 1974.

    Google Scholar 

  28. Hirsch, J. G.: Phagocytin, a bactericidal substance from polymorphonuclear leukocytes. J. Exp. Med. 103, 589–611 (1956).

    Article  PubMed  CAS  Google Scholar 

  29. Skarnes, R. C, Watson, D. W.: Characterization of leukin, an antibacterial factor from leukocytes active against grampositive pathogens. J. Exp. Med. 104, 829–845 (1956).

    Article  PubMed  CAS  Google Scholar 

  30. Klebanoff, S. J., Harmon, L. B.: Antimicrobial systems of mononuclear phagocytes. In: Mononuclear pha­gocytes, van Furth, R. (ed.), pp. 507–545. Oxford: Blackwell Scientific Publications 1975.

    Google Scholar 

  31. Stossel, T. P., Mason, R. J., Pollard, T. D.: Isolation and properties of phagocytic vesicles. II. Alveolar macrophages. J. Clin. Invest. 51, 604–614 (1972).

    Article  PubMed  CAS  Google Scholar 

  32. Zinsser, H.: Bacterial allergies and tissue reactions. Proc. Soc. Exp. Biol. Med. 22, 35 (1925).

    Google Scholar 

  33. Lurie, M. B.: Resistance to tuberculosis. Cambridge, Mass.: Harvard University Press 1964.

    Google Scholar 

  34. North, R. J.: The concept of the activated macrophage. J. Immunol. 121, 806–809 (1978).

    PubMed  CAS  Google Scholar 

  35. Rich, A. R.: The pathogenesis of tuberculosis. 2. ed. Springfield, 111.: Thomas 1951.

    Google Scholar 

  36. Mackaness, G. B., Blanden, R. V.: Cellular immunity. Progr. Allergy 11, 89 (1967).

    CAS  Google Scholar 

  37. Hahn, H.: Requirement for a bone marrow-derived component in the expression of cell-mediated antibacterial immuni­ty. Infect. Immun. 11, 949–954 (1975).

    PubMed  CAS  Google Scholar 

  38. Hahn, H.: Effects of dextran sulfate 500 on cell-mediated re­sistance to infection with listeria monocytogenes in mice. Infect. Immun. 10, 1105–1109 (1974).

    PubMed  CAS  Google Scholar 

  39. Reif, A. E., Allen, J. M. V.: The AKR thymic antigen and its distribution in leukemias and nervous tissues. J. Exp. Med. 120, 413 (1964).

    Article  PubMed  CAS  Google Scholar 

  40. Cantor, H., Boyse, E. A.: Lymphocytes as models for study of mammalian cel­lular differentiation. Immunol. Rev. 33, 105 (1977).

    Article  PubMed  CAS  Google Scholar 

  41. North, R. J.: Importance of thymus derived lym­phocytes to cell mediated immunity to infection. Cell. Immunol. 7, 166 (1973).

    Article  PubMed  CAS  Google Scholar 

  42. Kaufmann, S. H. E., Simon, M. M., Hahn, H.: Unveröffentlichte Befunde.

    Google Scholar 

  43. David, J. R., David, R. R.: Cellular hy­persensitivity and immunity. Progr. Allergy 16, 300 (1972).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Inst. für Med. Mikrobiologie der FU Berlin, Med. Poliklinik der Univ. Zürich, Deutschland

    H. Hahn & L. H. Block

Authors
  1. H. Hahn
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  2. L. H. Block
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Editor information

Editors and Affiliations

  1. Kliniken der Landeshauptstadt, D-6200, Wiesbaden, Deutschland

    B. Schlegel

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© 1979 J. F. Bergmann Verlag, München

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Hahn, H., Block, L.H. (1979). Antibakterielle Abwehrmechanismen. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 85. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85454-5_389

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  • DOI: https://doi.org/10.1007/978-3-642-85454-5_389

  • Publisher Name: J.F. Bergmann-Verlag

  • Print ISBN: 978-3-8070-0309-2

  • Online ISBN: 978-3-642-85454-5

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