Cholesterol and Lipoprotein Metabolism in Familial Hypercholesterolemia

  • D. Bilheimer
  • S. Grundy
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für innere Medizin book series (VDGINNERE, volume 85)


Familial Hypercholesterolemia is an example in which a single gene mutation leads to atherosclerosis. The disorder is inherited as an autosomal dominant trait. The heterozygote frequency in the general U.S. population is 1 in 500. However, because this disorder is associated with atherosclerosis, it is found in approximately one of every 20 survivors of a myocardial infarction. This high frequency makes Familial Hypercholesterolemia the most common simply inherited disorder in man.


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Copyright information

© J. F. Bergmann Verlag, München 1979

Authors and Affiliations

  • D. Bilheimer
    • 1
  • S. Grundy
    • 2
  1. 1.South Western Medical SchoolDallasUSA
  2. 2.San DiegoUSA

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