Enzymbestimmungen in Myokardbiopsien zur Unterscheidung zwischen der kongestiven Kardiomyopathie unklarer Ätiologie (COCM) und der Alkoholkardiomyopathie (ACM)

  • H.-P. Schultheiß
  • H.-D. Bolte
  • J. Cyran
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für innere Medizin book series (VDGINNERE, volume 85)

Zusammenfassung

Seit der Einführung der endomyokardialen Katheterbiopsie [1] besteht die Möglichkeit, biochemische Untersuchungen direkt am Myokardgewebe von Patienten durchzuführen. Eine biochemische Analyse liegt nahe, da morphologische Untersuchungen bisher keine eindeutigen Kriterien zur weiteren Differenzierung der kongestiven Kardiomyopathien (COCM) erbracht haben [2–4]. Aufgrund von Untersuchungen an kardiomyopathischen Hamstern besteht der Verdacht, daß eine Störung der oxydativen Phosphorylierung ursächlich an der Entstehung der COCM beteiligt ist [5–7]. Wir haben daher das Verteilungsmuster und die spezifische Aktivität der Lactat-Dehydrogenase-Isoenzyme (LDH) bestimmt. Diese spielen wegen der unterschiedlichen physikalischen, chemischen und katalytischen Eigenschaften eine entscheidende Rolle in der Regulation des NADNADH-Gleichgewichtes der Zelle [8, 9]. Somit kann man durch ihre Bestimmung auf den oxydativen Energiestoffwechsel der Zellen im untersuchten Gewebe rückschließen.

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Copyright information

© J. F. Bergmann Verlag, München 1979

Authors and Affiliations

  • H.-P. Schultheiß
    • 1
  • H.-D. Bolte
    • 1
  • J. Cyran
    • 1
  1. 1.Klinikum GroßhadernMed. Klinik I der Univ. MünchenDeutschland

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