84. Kongreß pp 503-512 | Cite as

Bone Marrow Transplantation for the Treatment of Aplastic Anemia and Acute Leukemia

  • R. Storb
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für innere Medizin book series (VDGINNERE, volume 84)


Marrow transplantation in man represents the clinical application of principles derived from studies in animals. The major impediment to the transplant is the donor-host histoincompatibility which is genetically determined. This is not a problem when donor and recipient are genetically identical twins (a syngeneic graft) — the infused marrow is readily accepted. Hence, simple infusion of twin marrow, without any immunosuppressive conditioning of the patient, is effective treatment for aplastic anemia. However, when donor and recipient are not genetically identical twins (an allogeneic graft), some degree of histoincompatibility must exist and constitutes a bidirectional immunologic barrier.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • R. Storb
    • 1
  1. 1.Fred Hutchinson Cancer Research Center and Dept. of Medicine, Division of OncologyUniv. of Washington School of MedicineSeattleUSA

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