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Bone Marrow Transplantation for the Treatment of Aplastic Anemia and Acute Leukemia

  • Conference paper
84. Kongreß

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 84))

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Zusammenfassung

Marrow transplantation in man represents the clinical application of principles derived from studies in animals. The major impediment to the transplant is the donor-host histoincompatibility which is genetically determined. This is not a problem when donor and recipient are genetically identical twins (a syngeneic graft) — the infused marrow is readily accepted. Hence, simple infusion of twin marrow, without any immunosuppressive conditioning of the patient, is effective treatment for aplastic anemia. However, when donor and recipient are not genetically identical twins (an allogeneic graft), some degree of histoincompatibility must exist and constitutes a bidirectional immunologic barrier.

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Author information

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center and Dept. of Medicine, Division of Oncology, Univ. of Washington School of Medicine, Seattle, USA

    R. Storb

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  1. R. Storb
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Editors and Affiliations

  1. Städt. Krankenanstalten, Wiesbaden, D-6200, Deutschland

    B. Schlegel

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© 1978 Springer-Verlag Berlin Heidelberg

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Storb, R. (1978). Bone Marrow Transplantation for the Treatment of Aplastic Anemia and Acute Leukemia. In: Schlegel, B. (eds) 84. Kongreß. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 84. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85453-8_90

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  • DOI: https://doi.org/10.1007/978-3-642-85453-8_90

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0307-8

  • Online ISBN: 978-3-642-85453-8

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