Pharmacodynamic Drug Interactions
Pharmacodynamic drug interactions occur when the target organ effects of one drug are altered by another. In those instances where the pharmacological action is increased, the interaction may be described as unidirectional: where the effect is diminished, the interaction is bidirectional. From a mechanistic viewpoint, pharmacodynamic interactions may be brought about by two (or more) drugs interacting either at a single type of subcellular (receptor) site, or at multiple sites within a single target organ or homeostatic system.
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