Skip to main content
SpringerLink
Log in

Renin and the Sympathetic Nervous System

  • Conference paper
Achtzigster Kongress

Part of the book series: Verhandlungen der Deutschen Gesellschaft für Innere Medizin ((VDGINNERE,volume 80))

  • 7 Accesses

Abstract

Fig. 1, from a review by Davis [1], is shown as a useful frame of reference to indicate the two basic mechanisms which have alternatively been suggested as responsible for stimulating the juxtaglomerular apparatus to secrete or release renin. The so-called stretch-receptor or baroceptor hypothesis, first advanced by Tobian [2] and by Skinner, McCubbin and Page [3], maintains that the juxtaglo-merular cells not only represent the producing site of renin, but also a sensor responsive to stretch of the afferent arteriole, in such a way that a stretch of the arteriole wall inhibits refill release. An alternative hypothesis, the so-called natrioceptive hypothesis, was first advanced by Vander [4, 5] and maintains that the primary receptors lie in the macula densa. These specific cells of the distal tubule would be responsive to the sodium in the tubular fluid, either to the sodium load (and presumably to intracellular sodium transport) according to Vander [6] or to sodium concentration in the tubular fluid according to Thurau [6, 8]. The relative role of the renal vascular receptor and of the macula densa has been recently assessed by Davis and his group [9] in the non-filtering kidney preparation: their present position is that there is a double intrarenal receptor system, to which both baro- and natrioceptive mechanisms contribute, but that in most instances the baroceptor is by far the most important mechanism [9].

Diagram of the juxtaglomerular apparatus, with indication of the vascular stretch receptor in the afferent arteriole, and of the natrioceptors in the macula densa. (From Davis, 1, by courtesy of the American Heart Association)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Davis, J. O.: Circulat. Res. 28, 301 (1971).

    Article  PubMed  CAS  Google Scholar 

  2. Tobian, L., Tomboulian, A., Janecek, J.: J. clin. Invest. 38, 605 (1959).

    Article  PubMed  CAS  Google Scholar 

  3. Skinner, S. L., McCubbin, J. W., Page, I. H.: Circulat. Res. 15, 64 (1964).

    Article  PubMed  CAS  Google Scholar 

  4. Vander, A. J., Miller, R.: Amer. J. Physiol. 207, 537 (1964).

    PubMed  CAS  Google Scholar 

  5. Vander, A. J.: Physiol. Rev. 47, 359 (1967).

    PubMed  CAS  Google Scholar 

  6. Vander, A. J., Carlson, J.: Circulat. Res. 25, 145 (1969).

    Article  PubMed  CAS  Google Scholar 

  7. Thurau, K., Schnermann, J., Nagel, W., Horster, M., Wohl, M.: Circulat. Res. 21 (Suppl. II), 79 (1967).

    PubMed  Google Scholar 

  8. Thurau, K., Dahlheim, H., Gruner, A., Mason, J., Granger, P.: Circulat. Res. 30/31 (Suppl. II) 182 (1972).

    Google Scholar 

  9. Davis, J. O.: Amer. J. Med. 55, 333 (1973).

    Article  PubMed  CAS  Google Scholar 

  10. Vander, A. J.: Amer. J. Physiol. 209, 659 (1965).

    PubMed  CAS  Google Scholar 

  11. Wathen, R. L., Kingsbury, W. S., Strounder, D. A., Schneider, E. G., Rostorfer, H. H.: Amer. J. Physiol. 209, 1012 (1965).

    PubMed  CAS  Google Scholar 

  12. Bunag, R. D., Page, I. H., McCubbin, J. W.: Circulat. Res. 19, 851 (1966).

    Article  PubMed  CAS  Google Scholar 

  13. Ueda, H., Yasuda, H., Takabatake, Y., Iizuka, M., Iizuka, T., Ihori, M., Sakamoto, Y.: Circulat. Res. 27 (Suppl. I I ), 195 (1970).

    Google Scholar 

  14. Johnson, J. A., Davis, J. O., Witty, R. T.: Circulat. Res. 29, 646 (1971).

    Article  PubMed  CAS  Google Scholar 

  15. Tanigawa, H., Allison, D. J., Assaykeen, T. A.: A comparison of the effects of various catecholamines on plasma renin activity alone and in the presence of adrenergic blocking agents. In: Hypertension ‘72, p. 37 ( Genest, J., Koiw, E., Eds.). Berlin-HeidelbergNew York: Springer 1972.

    Google Scholar 

  16. Winer, N., Chokshi, D. S., Walkenhorst, W. G.: Circulat. Res. 29, 239 (1971).

    Article  PubMed  CAS  Google Scholar 

  17. Chokshi, D. S., Yeh, B. K., Samet, P.: Proc. Soc. exp. Biol. (N.Y.) 140, 54 (1972).

    Article  CAS  Google Scholar 

  18. Reid, I. A., Schrier, R. W., Earley, L. E.: J. clin. Invest. 51, 1861 (1972).

    Article  PubMed  CAS  Google Scholar 

  19. Vandongen, R., Peart, W. S., Boyd, G. W.: Circulat. Res. 32, 290 (1973).

    Article  PubMed  CAS  Google Scholar 

  20. Introzzi, S., Manique, S. Y., Faffaele, T., O’Farrei, M. I.: Rev. Soc. argent. Biol. 25, 16 (1949).

    CAS  Google Scholar 

  21. Taquini, A. C., Blaquier, P., Taquini, A. C., Jr.: Canad. med. Ass. J. 90, 210 (1964).

    CAS  Google Scholar 

  22. Tobian, L., Branden. M., Maney, J.: Fed. Proc. 24, 405 (1965).

    Google Scholar 

  23. Loeffler, J. R., Stockigt, J. R., Ganong, W. F.: Neuroendocrinology 10, 129 (1972).

    Article  PubMed  CAS  Google Scholar 

  24. Coote, J. H., Johns, E. J., MacLeod, V. H., Singer, B.: J. Physiol. (Lond.) 226, 15 (1972).

    CAS  Google Scholar 

  25. Lagrange, R. G., Sloop, C. H., Schmid, H. E.: Circulat. Res. 33, 704 (1973).

    Article  CAS  Google Scholar 

  26. Ueda, H. Yasuda, H., Takabatake, U., Iizuka, M., Iizuka, T., Ihori, M., Yamamoto, M., Sakamoto, Y.: Jap. Heart J. 8, 498 (1967).

    Google Scholar 

  27. Passo, S. S., Assaykeen, T. A., Otsuka, K., Wise, B. L., Goldfien, A., Ganong, W. F.: Neuroendocrinology 7, 1 (1971).

    Article  PubMed  CAS  Google Scholar 

  28. Hodge, R. L., Lowe, R. D., Vane, J. R.: Nature (Lond.) 211, 491 (1966).

    Article  CAS  Google Scholar 

  29. Passo, S. S., Assaykeen, Y. A., Goldfien, A., Ganong, W. F.: Neuroendocrinology 7, 97 (1971).

    Google Scholar 

  30. Richardson, D., Stella, A., Leonetti, G., Bartorelli, A., Zanchetti, A.: Clin. Sci. 45, 2435 (1973).

    Google Scholar 

  31. Zanchetti, A., Richards-son, D. W., Stella, A., Leonetti, G., Bartorelli, A.: Brain stem control of renin release. Proc. Ist Symp. Nephrol, p. 201 ( Eisenbach, G. M., Ed. ). Hannover 1973.

    Google Scholar 

  32. Richardson, D., Stella, A., Leonetti, G., Bartorelli, A., Zanchetti, A.: Circulat. Res. (in press).

    Google Scholar 

  33. Haber, E., Koerner, T., Page, L. B., K.liman, B., Purnode, A.: J. Clin. Endocr. 29, 1349 (1969).

    Article  PubMed  CAS  Google Scholar 

  34. Ganong, W. F.: Fed. Proc. 32, 1782 (1973).

    PubMed  CAS  Google Scholar 

  35. Winer, N., Chokshi, D. S., Myung, S. Y., Freedman A D • J clin. Endocr. 29, 1168 (1969).

    Article  PubMed  CAS  Google Scholar 

  36. Folkow, B., Heymans, C., Neil, E.: Integrated aspects of cardiovascular regulation. Handbook of Physiology, Circulation (Hamilton, W. F., Dow, P., Eds.). Sect. 2, Vol. III, Chapt. 49, p. 1787. Washington, D. C.: American Physiological Society 1965.

    Google Scholar 

  37. Zanchetti, A.: Hypothalamic control of circulation. In: The nervous system and hypertension. Springfield, Ill.: C. Thomas (in publication).

    Google Scholar 

  38. Zehr, J. E., Feigl, E. O.: Circulat. Res. 32 (Suppl. I ), 17 (1973).

    Google Scholar 

  39. Folkow, B., Johansson, B., Oberg, B.: Acta physiol. scand. 47, 262 (1959).

    Article  PubMed  CAS  Google Scholar 

  40. Fasola, A. F., Martz, B. L., Helmer, O. M.: J. appl. Physiol. 25, 410 (1968).

    Google Scholar 

  41. Brown, J. J., Davies, D. L., Lever, A. F., McPherson, D., Robertson, J. I. S.: Clin. Sci. 30, 279 (1966).

    PubMed  CAS  Google Scholar 

  42. Cohen, E. L., Conn, J. W., Rovner, D. R.: J. clin. Invest. 46, 418 (1967).

    Article  PubMed  CAS  Google Scholar 

  43. Gordon, R. D., Kuchel, O., Liddle, G. W., Island, D. P.: J. clin. Invest. 46, 599 (1967).

    Article  PubMed  CAS  Google Scholar 

  44. Oparil, S., Vassaux, C., Sanders, C. A., Haber, E.: Circulation 41, 89 (1970).

    Google Scholar 

  45. Cuche, J. L., Kuchel, O., Barbeau, A., Boucher, R., Genest, J.: Clin. Sci. 43, 481 (1972).

    PubMed  CAS  Google Scholar 

  46. Michelakis, A. M., McAllister, R. G.: J. clin. Endocr. 34, 386 (1972).

    Article  PubMed  CAS  Google Scholar 

  47. Love, D. R., Brown, J. J., Chinn, R. H., Johnson, R. H., Lever, A. F., Park, D. M., Robertson, J. I. S.: Clin. Sci. 41, 289 (1971).

    PubMed  CAS  Google Scholar 

  48. Bozovic, L., Castenfors, J., Oro, L.: Acta med. scand. 188, 385 (1970).

    Article  PubMed  CAS  Google Scholar 

  49. Johnson, R. H., Park, D. M.: Clin. Sci. 44, 539 (1973).

    PubMed  CAS  Google Scholar 

  50. Greene, J. A., Jr., Vander, A. J., Kowalczyk, R. S.: J. Lab. clin. Med. 71, 586 (1968)

    PubMed  Google Scholar 

  51. Blaufox, M. D., Lewis, E. Q., Jagger, P., Lauler, D., Hickler, R.: New Engl. J. Med. 280, 62 (1969).

    Article  PubMed  CAS  Google Scholar 

  52. Hodge, R. L., Lowe, R. D., Vane, J. R.: J. Physiol. (Loud.), 185, 613 (1966).

    CAS  Google Scholar 

  53. Blaine, E. H., Davis, J. O., Prewitt, R. L.: Amer. J. Physiol. 220, 1593 (1971).

    PubMed  CAS  Google Scholar 

  54. Vander, A. J., Luciano, J. R.: Circulat. Res. 20 (Suppl. I I ), 69 (1967).

    Google Scholar 

  55. Vander, A. J., Luciano, J. R.: Amer. J. Physiol. 212, 651 (1967).

    PubMed  CAS  Google Scholar 

  56. Zschiedrich, H., Hofbauer, K. G., Rauh, W.: Naunyn-Schmiedeberg’s Arch. Pharmacol. 277, Suppl. R. 89 (1973).

    Google Scholar 

  57. Hofbauer, K. G., Zschiedrich, H., Rauh, W., Hackental, E., Gross, F.: Renin release and renin-substrate reaction in the isolated perfused rat kidney. Proc. 1st Symp. Nephrol, p. 214 ( Eisenbach, G. M., Ed. ). Hannover 1973.

    Google Scholar 

  58. Gotshall, R. W., Davis, J. O., Shade, R. E., Spielman, W., Johnson, J. A., Braverman, B.: Amer. J. Physiol. 225, 344 (1973).

    PubMed  CAS  Google Scholar 

  59. Brubacher, E. S., Vander, A. J.: Amer. J. Physiol. 214, 15 (1968).

    PubMed  CAS  Google Scholar 

  60. Mogil, R. A., Itskovitz, H. D., Russell, J. D., Murphy, J. J.: Amer. J. Physiol. 216, 693 (1969).

    PubMed  CAS  Google Scholar 

  61. Hedeland, H., Dymling, J. F., Hokfelt, B.: Acta endocr. (Kbh.) 62, 399 (1969).

    CAS  Google Scholar 

  62. Stella, A., Cafiero, F., Zanchetti, A.: Europ. J. clin. Invest. 1974 (in press).

    Google Scholar 

  63. Leonetti, G., Mayer, G., Morganti, A., Terzoli, L., Zahnchetti, A., Morselli, P. L., Di Salle, E., Chidsey, C. A.: Europ. J. clin. Invest. 1974 (in press).

    Google Scholar 

  64. Brennan, L. A., Jr., Malvin, R. L., Jochim, K. L., Roberts, D. E.: Amer. J. Physiol. 221, 273 (1971).

    PubMed  CAS  Google Scholar 

  65. Thames, M. D., Zubair-Ul-Hassan, Brackett, N. C., Jr., Lower, R. R., Kontos, H. A.: Amer. J. Physiol. 221, 1115 (1971).

    CAS  Google Scholar 

  66. Oberg, B., White, S.: Acta physiol. scand. 80, 383 (1970).

    Article  PubMed  CAS  Google Scholar 

  67. Pelletier, C. L., Edis, A. J., Shepherd, J. T.: Circulat. Res. 29, 626 (1971).

    Article  PubMed  CAS  Google Scholar 

  68. Karim, F., Kidd, C., Malpus, C. M., Penna, P. E.: J. Physiol. (Loud.) 227, 243 (1972).

    CAS  Google Scholar 

  69. Clement, D. L., Pelletier, C. L., Shepherd, J. T.: Circulat. Res. 31, 824 (1972).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Ricerche Cardiovascolari, Istituto di Semeiotica Medica I, Univ. and Centro di Ricerche Cardiovascolari, CNR, Milano, Italy

    A. Zanchetti & A. Stella

Authors
  1. A. Zanchetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Stella
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1974 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Zanchetti, A., Stella, A. (1974). Renin and the Sympathetic Nervous System. In: Achtzigster Kongress. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 80. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85449-1_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85449-1_21

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0293-4

  • Online ISBN: 978-3-642-85449-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation