Abstract
Both mice and men have neuroendocrine mechanisms based on the hypothalamus which respond to the powerful emotions of attachment and competitive behavior. We will present behavioral, physiological, and biochemical evidence that mice can experience sustained arousal as a result of social interaction. The same sympathetic adrenal-medullary defense reaction and the same pituitary adrenal-cortical alarm response, which determine the elevations of systolic arterial blood pressure in men and in experimental primates, also operate in mice. We will show that when a mouse has spent a large fraction of its life-span in a population cage where there is social discorder cardiovascular disease ensues. At first the changes are reversible, but, as in the human condition, after a long time, the measured pressures remain elevated and arteriosclerosis ensue [1].
This work has been supported by the National Institutes of Health Grant No. MH 19441 and involves collaboration with the Section on Pharmacology of the Laboratory of Clinical Science, National Institute of Mental Health.
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References
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Henry, J.P., Ely, D.L., Stephens, P.M. (1974). The Role of Psychosocial Stimulation in the Pathogenesis of Hypertension. In: Achtzigster Kongress. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 80. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85449-1_17
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DOI: https://doi.org/10.1007/978-3-642-85449-1_17
Publisher Name: J.F. Bergmann-Verlag, Munich
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