Treatment of Menopausal Symptoms with Extracts of Cimicifuga Racemosa: In vivo and in vitro Evidence for Estrogenic Activity

  • H. Jarry
  • Ch. Gorkow
  • W. Wuttke


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bates GW (1981) On the nature of the hot flash. Clinical Obstetrics and Gynecology 24: 231–241PubMedCrossRefGoogle Scholar
  2. 2.
    Bergmann J (1940) Cimicifuga und die Hypophyse. Hippokrates 11: 327–330Google Scholar
  3. 3.
    Caligaris L, Astrada JJ, Taleisnik S (1971) Release of luteinizing hormone induced by estrogen injection into ovariectomized rats. Endocrinology 88 (1971): 810–815.PubMedCrossRefGoogle Scholar
  4. 4.
    Clarke IJ, Cummins JT (1982) The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone ( LH) secretion in ovariectomized ewes. Endocrinology 111: 1737–1739PubMedCrossRefGoogle Scholar
  5. 5.
    Düker EM, Kopanski L, Jarry H, Wuttke W (1991) Effects of extracts from cimicifuga racemosa on gonadotropin release in menopausal women and ovariectomized rats. Planta Medica 57 420–424PubMedCrossRefGoogle Scholar
  6. 6.
    Gay VL, Sheth NA (1972) Evidence for a periodic release of LH in castrated male and female rats. Endocrinology 90: 158–162.PubMedCrossRefGoogle Scholar
  7. 7.
    Harms PG, Ojeda SA (1974) A rapid and simple procedure for chronic cannulation of the rat jugular vein. J Appl Physiol 36: 391–392PubMedGoogle Scholar
  8. 8.
    Harnischfeger G, Stolze H (1983) Bewährte Wirksubstanzen aus Naturstoffen: Traubensilberkerze. Notabene Medici (1980) 10: 446–450Google Scholar
  9. 9.
    Hughes CL, Chakinala MM, Reece SG, Miller RN, Schomberg DW, Basham KB (1991) Acute and subacute effects of the naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat. Reprod Toxicol 5: 133–137PubMedCrossRefGoogle Scholar
  10. 10.
    Jarry H, Harnischfeger G (1985) Studies on the endocrine effects of the contents of Cimicifuga racemosa: 1. Influence on the serum concentration of pituitary hormones in ovariectomized rats. Planta medica 51: 46–49PubMedCrossRefGoogle Scholar
  11. 11.
    Jarry H, Harnischfeger G, Düker, E (1985) Studies on the endocrine effects of the contents of Cimicifuga racemosa: 2. In vitro binding of compounds to estrogen receptors. Planta medica 51: 316–319PubMedCrossRefGoogle Scholar
  12. 12.
    Jarry H, Einspanier A, Kanngießer L, Dietrich M, Pitzel L, Holtz W, Wuttke W (1990) Release and effects of oxytocin on estradiol and progesterone secretion in porcine corpora lutea as measured by an in vivo microdialysis system. Endocrinology 126: 2350–2358PubMedCrossRefGoogle Scholar
  13. 13.
    Knobil E (1980) The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 36: 53–88.PubMedGoogle Scholar
  14. 14.
    Knobil E, Neill JD (1988) Physiology of reproduction, Raven Press, New YorkGoogle Scholar
  15. 15.
    Korenman SG (1970) Relation between estrogen inhibitory activity and binding to cytosol of rabbit and human uterus. Endocrinology 87: 1119–1123CrossRefGoogle Scholar
  16. 16.
    Meldrum DR, Shamnonki IM, Frumar AM, Tataryn IV, Chang RF, Judd HL (1979) Elevations in skin temperature of the fingers as an objective index of postemnopausal hot flashes: Standardization of the technique. Am J Obstet Gynecol 135: 713–717PubMedGoogle Scholar
  17. 17.
    Meldrum DR, Tataryn IV, Frumar AM, Erlik Y, Lu KH, Judd HL (1980) Gonadotropins, estrogens and adrenal steroids during menopausal hot flashes. J Clin Endocrinol Metab 50: 685–689PubMedCrossRefGoogle Scholar
  18. 18.
    Rivier C, Vale W (1991) Effect of recombinant activin-A on gonadotropin secretion in the female rat. Endocrinology 129: 2463–2465.PubMedCrossRefGoogle Scholar
  19. 19.
    Rivier C, Schwall R, Mason A, Burton L, Vaughan J, Vale W (1991) Effect of recombinant inhibin on luteinizing hormone and follicle-stimulating hormone secretion in the rat. Endocrinology 128: 1548–1554.PubMedCrossRefGoogle Scholar
  20. 20.
    Scaglia H, Medina M, Pinto-Ferreira AL, Vazques G, Gual C, Perez-Palacios G (1976) Pituitary LH and FSH secretion and responsivenness in women of old age. Acta Endocrinologica 81: 673–684PubMedGoogle Scholar
  21. 21.
    Schiff I, Ryan K (1980) Benefits of estrogen replacement. Obstetrical and Gynecological survey 35: 400–411CrossRefGoogle Scholar
  22. 22.
    Stoll W (1987) Phytotherapeutikum beeinflußt atrophisches Vaginalepithel: Doppelblindversuch Cimicifuga vs. Ostrogenpräparat. Therapeutikum 1: 23–32Google Scholar
  23. 23.
    Sutherland RL, Jordan VC (1981) Nonsteroidal antiestrogens Academic Press, SydneyGoogle Scholar
  24. 24.
    Tataryn IV, Meldrum DR, Lu KH, Frumar AM, Judd HL (1979) LH, FSH and skin temperature during the menopausal hot flash. J Clin Endocrinol Metab 49: 152–154PubMedCrossRefGoogle Scholar
  25. 25.
    Warnecke G (1985) Beeinflussung klimakterischer Beschwerden durch ein Phytotherapeutikum. Erfolgreiche Therapie mit Cimicifuga-Monoextrakt. Med Welt 36: 871–874Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1995

Authors and Affiliations

  • H. Jarry
    • 1
  • Ch. Gorkow
    • 1
  • W. Wuttke
    • 2
  1. 1.Abteilung Klinische und Experimentelle EndokrinologieUniversitäts-Frauenklinik GöttingenGöttingenDeutschland
  2. 2.Abteilung Klinische und Experimentelle EndokrinologiePlantamed Arzneimittel GmbHNeumarktDeutschland

Personalised recommendations