Animal Studies

Abstract

In order to achieve antibacterial activity, an antimicrobial agent must reach tissue concentrations above the MIC of that drug against the bacteria. Concentrations of various quinolones in prostatic tissue, prostatic fluid, and vaginal and urethral secretions were examined in a canine model (II, III, IV). Briefly, the drug was given intravenously to achieve steady-state conditions. At various intervals, samples of vaginal, urethral, and prostatic secretions were taken. At the end of the study, the animals were sacrificed. The organs were removed and homogenized, and drug concentrations were determined by bioassay. These studies demonstrated that all of the quinolones reached very high tissue concentrations, sometimes several times higher than the plasma concentration.