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Fleroxacin (Ro 23-6240) Distribution in Canine Prostatic Tissue and Fluids

  • Chapter
Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones

Part of the book series: Fortschritte der Urologie und Nephrologie ((2824,volume 27))

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Abstract

The distributiou of Oeroxacin (Ro 23–6240) in canine prostatic tissue and Ouids was investigated under steady-state conditions during intravenous infusion. Mean ratios of Oeroxocin concentration in tissue and Ouids over concentration in plasma were 1.57 ± 0.25 for prostatic tissue, 1.12 ± 0.28 for prostatic secretion, and 0.93 ± 0.14 for prostatic interstitial Ouid. These levels and concentrations in urine were several times higher than the MlC for most pathogens that cause chrouic bacterial prostatitis and urinary tract infection. The MlCs for several isolates of Escherichia coli were only slightly affected by canine prostatic secretion, human prostatic tissue extract, and human urine. Clinical trials with Oeroxacin appear justified for chronic bacterial prostatitis and urinary tract infection,

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Author notes

  1. Thomas C. Gasser

    Present address: Urology Section, University Hospital, 4031, Basel, Switzerland

Authors and Affiliations

  1. Urology Section, Surgical Service, William S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, Wisconsin, USA

    Thomas C. Gasser, Peder H. Graversen & Paul O. Madsen

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  1. Thomas C. Gasser
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  2. Peder H. Graversen
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  3. Paul O. Madsen
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© 1992 Dr. Dietrich SteinkopffVerlag & Co. KG, Darmstadt

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Gasser, T.C., Graversen, P.H., Madsen, P.O. (1992). Fleroxacin (Ro 23-6240) Distribution in Canine Prostatic Tissue and Fluids. In: Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones. Fortschritte der Urologie und Nephrologie, vol 27. Steinkopff. https://doi.org/10.1007/978-3-642-85422-4_11

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  • DOI: https://doi.org/10.1007/978-3-642-85422-4_11

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0942-9

  • Online ISBN: 978-3-642-85422-4

  • eBook Packages: Springer Book Archive

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