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Fleroxacin (Ro 23-6240) Distribution in Canine Prostatic Tissue and Fluids

  • Thomas C. Gasser
  • Peder H. Graversen
  • Paul O. Madsen
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 27)

Abstract

The distributiou of Oeroxacin (Ro 23–6240) in canine prostatic tissue and Ouids was investigated under steady-state conditions during intravenous infusion. Mean ratios of Oeroxocin concentration in tissue and Ouids over concentration in plasma were 1.57 ± 0.25 for prostatic tissue, 1.12 ± 0.28 for prostatic secretion, and 0.93 ± 0.14 for prostatic interstitial Ouid. These levels and concentrations in urine were several times higher than the MlC for most pathogens that cause chrouic bacterial prostatitis and urinary tract infection. The MlCs for several isolates of Escherichia coli were only slightly affected by canine prostatic secretion, human prostatic tissue extract, and human urine. Clinical trials with Oeroxacin appear justified for chronic bacterial prostatitis and urinary tract infection,

Keywords

Urinary Tract Infection Human Urine Prostatic Tissue Chronic Bacterial Prostatitis Prostatic Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. Dietrich SteinkopffVerlag & Co. KG, Darmstadt 1992

Authors and Affiliations

  • Thomas C. Gasser
    • 1
  • Peder H. Graversen
    • 1
  • Paul O. Madsen
    • 1
  1. 1.Urology Section, Surgical ServiceWilliam S. Middleton Memorial Veterans Administration HospitalMadisonUSA

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