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Dynamic coupling of External to Cellular Respiration During Exercise

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Computerized Cardiopulmonary Exercise Testing

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Abstract

Analysis of the pattern of coupling of external to cellular respiration provides considerable insight into circulatory and ventilatory control. Except for the first 15 to 20 s of exercise (Phase I), the circulation does not over-perfuse the tissues nor does the ventilatory control mechanism cause hyperventilation of the pulmonary blood. During Phase I, however, the pattern of response is more complex. At the onset of very low work rate exercise, the increases in heart rate and stroke volume are normally so rapid, that the cardiac output transiently exceeds the metabolic requirement. As a result, \( \dot V{O_2} \) and heart rate decrease as work is sustained [15]. At higher work rates, heart rate continues to increase after Phase I, but \( \dot V{O_2} \) exceeds the heart rate increase causing an increase in O2-pulse ( \( \dot V{O_2} \) /heart rate) which is usually complete by one minute [15]. With prolonged exercise, O2-pulse decreases slightly presumably due to increased skin blood flow secondary to thermoregulation [4, 17].

Supported by Public Health Service Grant HL 11907

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Reference

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Author information

Authors and Affiliations

  1. Respiratory Medicine, A-15, Harbor-UCLA Med. Center, 1000 W. Carson Street, Torrance, CA, 90509, USA

    K. Wasserman M.D., Ph. D.

  2. Harbor-UCLA Medical Center, Torrance, California, USA

    A. Koike, K. Sietsema & R. Casaburi

Authors
  1. K. Wasserman M.D., Ph. D.
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  2. A. Koike
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  3. K. Sietsema
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  4. R. Casaburi
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Editor information

Editors and Affiliations

  1. Klinik III für Innere Medizin, Universität Köln, Joseph-Stelzmann-Str. 9, 5000, Köln 41, Deutschland

    U. J. Winter  & H. W. Höpp  & 

  2. Harbor UCLA, 1000 W. Carson Street, 90509, Torrance, CA, USA

    K. Wasserman

  3. II. Medizinische Klinik und Poliklinik, Universität Mainz, Langenbeckstraße 1, 6500, Mainz, Deutschland

    N. Treese

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© 1991 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Wasserman, K., Koike, A., Sietsema, K., Casaburi, R. (1991). Dynamic coupling of External to Cellular Respiration During Exercise. In: Winter, U.J., Wasserman, K., Höpp, H.W., Treese, N. (eds) Computerized Cardiopulmonary Exercise Testing. Steinkopff. https://doi.org/10.1007/978-3-642-85404-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-85404-0_2

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85406-4

  • Online ISBN: 978-3-642-85404-0

  • eBook Packages: Springer Book Archive

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