Abstract
In patients with chronic obstructive pulmonary disease (COPD), exercise performance is limited due to reduced ventilatory capacity [6, 9, 15, 23]. Airflow obstruction and its quantitative impact on exercise tolerance is still the subject of investigation [6, 9, 20, 25, 31, 34, 36]. Inhalative therapy of COPD with sympathomimetic and anticholinergic bronchodilators is established [1, 31]. The effects of these agents on exercise performance, however, are controversially discussed [9, 10, 19]. Tachycardia and increase of myocardial oxygen consumption are well-known side-effects of these substances [13, 35].
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References
American Thoracic Society: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis (1987); 136: 225
Andersen G (1983) Anticholinergic drugs in airways obstruction. Postgrad Med J 59: 64
Anthonisen NR, Wright EC, IPPB Trial Group (1986) Bronchodilator response in chronic obstructive pulmonary disease. Am Rev Respir Dis 133: 814
Bauer R (1985) Zur Pharmakologie des Bronchospasmolytikums Oxitropiumbromid. Arzneim Forsch 35: 435
Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Phyiol 60: 2020
Belman MJ (1986) Exercise in chronic obstructive pulmonary disease. Clinics Chest Med 7: 585
Braunwald E (ed) (1988) Heart disease 3rd edition Philadelphia WB Saunders
Choo-Kang YFJ, Simpson WT, Grant IWB (1969) Controlled comparison of the bronchodilator effect of three ß-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J 2: 287
Clark JC, Cochrane LM (1988) Assessment of work performance in asthma for determination of cardiorespiratory fitness and training capacity. Thorax 43: 745
Conolly CK, Chan NS (1987) Salbutamol and ipratropium in partially reversible airway obstruction. Br J Dis Chest 81: 55
Firstrater E, Mizrachi E, Topilski M (1981) The effect of vagolytic drugs on airway obstruction in patients with bronchial asthma. Ann Allergy 46: 332
Floher E, Bischoff KO (1989) Oxitropium bromide, a new anticholinergic drug in a dose-response and placebo comparison in obstructive airway disease. Respiration 38: 98
Goodman LS, Gilman A (1989) The pharmacological basis of therapeutics (7th ed.) New York, Mc Millan
Gross NJ, Skorodin MS (1984) Anticholinergic, antimuscarinic bronchodilators. Am Rev Respir Dis 129: 856
Gross NJ (1986) COPD: a disease of reversible airflow obstruction. Am Rev Respir Dis 113: 725
Gross NJ, Bankwala Z: Effects of an anticholinergic bronchodilator on arterial blood gases of hypoxemic patients with chronic obstructive pulmonary disease (1987) comparison with a betaadrenergic agent. Am Rev Respir Dis 136: 1091
Guyatt GH, Towsend M, Keller J, Singer J, Nogradi S (1989) Measuring functional status in chronic lung disease: conclusions from a randomized control trial. Respir Med 83: 293
Hensley MJ, O’Cain CF, McFadden ER jr, Ingram RH jr (1978) Distribution of bronchodilatation in normal subjects: beta agonist versus atropine. J Appl Physiol 45: 778
Ingeman-Hansen T, Bundgaard A, Halkjer-Kristensen J, Siggard-Andersen J, Weeke B (1980) Maximal oxygen consumption rate in patients with bronchial asthma — the effect of ßz-adrenoceptor stimulation. Scand J Clin Lab Invest 40: 99
Jones NL, Jones G, Edwards RHT (1971) Exercise tolerance in chronic airway obstruction. Am Rev Respir Dis 103: 477
Kennedy MCS, Simpson WT (1969) Human pharmacological and clinical studies on salbutamol: A specific 13-adrenergic bronchodilator. Br J Dis Chest 2: 165
Leitch AG, Hopkin JM, Ellis DA, Merchant S, McHardy GJR (1978) The effect of aerosol ipratropium bromide and salbutamol on exercise tolerance in chronic bronchitis. Thorax 33: 711 )
Loke J, Mahler D, Man SFP, Wiedeman HP, Matthay RA (1984) Exercise impairment in chronic obstructive pulmonary disease. Clin Chest Med 5: 121
Lulling J, Delwiche JP, Prignot J (1981) Early bronchodilating effect of oxitropium bromide in comparison with ipratropium bromide. Respiration 42: 188
McGavin CR, Artvinly M, Naoe H, McHardy GJR (1978) Dyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease. Br Med J 2: 241
Minette A, Marcq M (1979) Oxitropium bromide, an advance in the field of anticholinergic bronchodilating treatments. Preliminary results. Rev Inst Hyg Mines 34: 115
Mols P, Ham H, Naeije N, Dechamps P, Huyn Ch, Vandenbosch L, Sergysels R (1988) How does salbutamol improve the ventricular performance in patients with chronic obstructive pulmonary disease? Cardiovasc Pharmacol 12: 127
Neuberg GW, Friedman SH, Weiss MB, Herman MV (1988) Cardiopulmonary exercise testing. The clinical value of gas exchange data. Arch Intern Med 148: 2221
Neuberg GW (1990) Cardiopulmonary exercise testing. 97: 257
Pakes GE (1984) Anticholinergic drugs. In: Buckle DR, Smith H (eds.): Development of antiasthmatic drugs. London: Butterworths
Paterson JW, Woolcock AJ, Shenfield GM (1979) Bronchodilator drugs. Am Rev Resp Dis 120: 1149
Petrie GR, Palmer KNV (1975) Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma. Br Med J 1: 430
Riding WD, Dinda P, Catterjee SS (1970) The bronchodilator and cardiac effects of five pressure-packed aerosols in asthma. Br J Dis Chest 64: 37
Spiro SG, Hahn HL, Edwards RHT, Pride NB (1975) An analysis of the physiological strain of exercise in patients with chronic obstructive bronchitis. Thorax 30: 415
Svedmyr N (1977) Treatment with beta-adrenostimulants. Scand J Resp Dis 58: 5
Swinburn CR, Wakefield JM, Jones PW (1985) Performance, ventilation and oxygen consumption in three different types of exercise tests in patients with chronic obstructive lung disease. Thorax 40: 581
Wasserman K (1987) Determinants and detection of anaerobic threshold and consequences of exercise above it. Circulation 76 (suppl VI): 29
Wasserman K, Hansen JE, Sue DY, Whipp BJ (1987) Principles of exercise testing and interpretation. Philadelphia: Lea and Febiger
Weber KT, Janicki JS (1986) Cardiopulmonary exercise testing. Philadelphia: WB Saunders
Whipp BJ (1987) Dynamics of pulmonary gas exchange. Circulation (1987) 76 (suppl VI): 18
Zar JH (1984) Biostatistical analysis ( 2nd ed. ), Prentice-Hall, Inc., Englewood Cliffs, New Jersey
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© 1991 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
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van Erckelens, F. et al. (1991). Effects of Inhaled Salbutamol and Oxitropium Bromide on Cardiopulmonary Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease and Coronary Artery Disease. In: Winter, U.J., Wasserman, K., Höpp, H.W., Treese, N. (eds) Computerized Cardiopulmonary Exercise Testing. Steinkopff. https://doi.org/10.1007/978-3-642-85404-0_17
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DOI: https://doi.org/10.1007/978-3-642-85404-0_17
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