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Ascending Multiple-Dose Study of the Tolerability, Pharmacological Effects, and Kinetics of the Antiarrhythmic Diprafenone in Healthy Volunteers

  • P. H. Hinderling
  • W. Holyoak
  • T. Koziol
  • J. Kondracki
  • P. Marrott
  • G. Woo
  • A. Rommel
Conference paper

Zusammenfassung

Diprafenone, a new Class Ic antiarrhythmic drug, is currently under clinical investigation in both Europe and the United States.

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References

  1. 1.
    Guelker H, Thale J, Olbing B, Heuer H, Frenking B, Bender F (1986) Drug Res 35: 1387Google Scholar
  2. 2.
    Wong S, Sullivan M, Ambelas E, Troy H, Barbati R, Winters R, Reiser J. (1985) The Pharmacologist 27:126Google Scholar
  3. 3.
    Wagner F, Sachs W, Trenk D, Jaehnchen E, (1987) Abstract 53rd Annual Conference of the German Society for Cardiac and Circulatory Research, April 24–26, MannheimGoogle Scholar
  4. 4.
    Report 85284, IND 27746Google Scholar
  5. 5.
    Jaehnchen E, (1987) Personal Report, Helopharm AG, West-Berlin, FRGGoogle Scholar
  6. 6.
    Heuer H, Guelker H, Hasfeld M, Frenking B, Behrenbeck Th, Bender F (1987) Z. Kardiol. 76: 415PubMedGoogle Scholar
  7. 7.
    Bazett HC (1920) 7: 353–369Google Scholar
  8. 8.
    Ritschel WA (1986) Handbook of Basic Pharmacokinetics, 3rd edition, Drug Intelligence Publications, Inc., Hamilton, EL, pp. 332–339Google Scholar
  9. 9.
    Internal Medicine, Editor Stein JH (1986) Little Brown, Inc., Boston/Toronto, 2nd edition, p. 331Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1990

Authors and Affiliations

  • P. H. Hinderling
    • 1
    • 3
  • W. Holyoak
    • 1
  • T. Koziol
    • 2
  • J. Kondracki
    • 1
  • P. Marrott
    • 1
  • G. Woo
    • 1
  • A. Rommel
    • 1
  1. 1.Medical DepartmentBerlex Laboratories, Inc.Cedar KnollsUSA
  2. 2.Preclinical DepartmentBerlex Laboratories, Inc.Cedar KnollsUSA
  3. 3.Berlex Laboratories, Inc.WayneUSA

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