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Studies on the Reproductive Toxicity of Diprafenone in Rats

  • I. Chahoud
  • A. Schimmel
  • D. Neubert
Conference paper

Abstract

The studies with diprafenone were aimed at evaluating possible adverse effects on reproduction, including male and female fertility, as well as embryo/fetal and perinatal/postnatal development in rats. The studies were performed as usual in three parts: Segment I, II, and III of the FDA or OECD.

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References

  1. 1.
    Dawson, AB, (1926) A note on the staining of the skeleton of cleared specimens with alizarin red. S Stain Technol 1: 123Google Scholar
  2. 2.
    Neubert, D, Stahlmann, R, Chahoud, I, Bochert, G (1985) Some aspects of prenatal toxicology. Trends in Pharmacol Sci, Fest (Fed Eur Soc Toxicol) Suppl 1–6Google Scholar
  3. 3.
    Sterz, H (1977) Routine examination of rat and rabbit fetuses for malformation of internal organs: combination of Barrow’s and Wilson’s methods. In: Methods in Prenatal Toxicology (Neubert, D, Merker, H.-J, Kwasigroch, TE, eds), Georg Thieme Publ, Stuttgart, pp. 113–122Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1990

Authors and Affiliations

  • I. Chahoud
    • 1
  • A. Schimmel
    • 1
  • D. Neubert
    • 1
  1. 1.Institut für Toxikologie und EmbryopharmakologieFreie Universität BerlinBerlin 33Germany

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